ARFGAP1 and APOC3

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		ARFGAP1	APOC3
Name		ARF GTPase activating protein 1	apolipoprotein C3
Structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Synapse	Extracellular Region Extracellular Space Early Endosome Very-low-density Lipoprotein Particle Intermediate-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Chylomicron Extracellular Exosome
	Molecular Function	GTPase Activator Activity Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding Phospholipid Binding Lipid Binding Cholesterol Binding Lipase Inhibitor Activity High-density Lipoprotein Particle Receptor Binding
	Biological Process	Protein Transport Vesicle-mediated Transport Regulation Of Endocytosis Regulation Of ARF Protein Signal Transduction	Lipid Metabolic Process Triglyceride Metabolic Process Lipid Transport G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Triglyceride Catabolic Process Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Negative Regulation Of High-density Lipoprotein Particle Clearance Negative Regulation Of Low-density Lipoprotein Particle Clearance Lipid Catabolic Process Triglyceride Catabolic Process Regulation Of Cdc42 Protein Signal Transduction Cholesterol Efflux Phospholipid Efflux High-density Lipoprotein Particle Remodeling Very-low-density Lipoprotein Particle Assembly Chylomicron Remnant Clearance Lipoprotein Metabolic Process Cholesterol Homeostasis Reverse Cholesterol Transport Negative Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Lipid Metabolic Process Negative Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Lipid Catabolic Process Negative Regulation Of Cholesterol Import Triglyceride Homeostasis
Pathways		XBP1(S) activates chaperone genes COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Clathrin-mediated endocytosis	Chylomicron assembly Chylomicron remodeling HDL remodeling Retinoid metabolism and transport Retinoid metabolism and transport
Drugs		None	Copper Volanesorsen
GWAS		No GWAS studies recorded	Blood protein levels ( 30072576 ) Body mass index ( 31978080 ) Cholesterol, total ( 19060911 20686565 ) Coronary heart disease ( 21378990 ) Delirium ( 29631748 ) Fasting triglyceride levels ( 32603185 ) HDL cholesterol ( 28270201 19060906 26582766 20864672 30275531 20686565 ) HDL cholesterol levels ( 28334899 ) Hematological and biochemical traits ( 20139978 ) High density lipoprotein cholesterol levels ( 28548082 ) Hypertriglyceridemia ( 23505323 ) LDL cholesterol ( 20864672 20686565 19060911 18179892 ) LDL cholesterol levels ( 28334899 ) Lipid metabolism phenotypes ( 22286219 ) Lipid traits ( 30576415 24386095 ) Lipoprotein (a) - cholesterol levels ( 25575512 ) Metabolite levels ( 22916037 ) Platelet count ( 27863252 ) Plateletcrit ( 27863252 32888494 ) Postprandial triglyceride levels ( 32603185 ) Red cell distribution width ( 32888494 ) Refractive error ( 32231278 ) Total cholesterol levels ( 28334899 ) Triglyceride levels ( 26763881 28334899 28371326 28548082 ) Triglycerides ( 26582766 21909109 20864672 20686565 20139978 19074352 19060911 19060906 18193044 18193043 )
Interacting Genes		39 interacting genes: AGTR1 APOB APOC3 APOE APP ARF1 ASB10 COPA COPS5 CRYAA CSNK1D CYTH2 FOS GABARAPL1 GABARAPL2 GRN HRAS KDELR1 KRTAP10-9 KRTAP3-2 KRTAP9-2 LRRK2 MAP1LC3B MED27 PRKACB RAB23 RABGAP1L RASIP1 REEP5 RFC3 RGS2 RPL11 SLC25A21-AS1 SLC6A1 SMN1 SNCA TK1 TMED2 TRIM23	7 interacting genes: ARFGAP1 ERGIC3 FAM209A GPX8 SNCA SOX4 VKORC1
Entrez ID		55738	345
HPRD ID		06443	00132
Ensembl ID		ENSG00000101199	ENSG00000110245
Uniprot IDs		Q53F62 Q8N6T3	A3KPE2 P02656
PDB IDs		3DWD 3O47	2JQ3
GO Terms Enriched among Interactors		Intermediate-density Lipoprotein Particle Protein-containing Complex Organization Phospholipid Binding Vesicle-mediated Transport Very-low-density Lipoprotein Particle Golgi Apparatus Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Protein-containing Complex Assembly Lipoprotein Metabolic Process Plasma Lipoprotein Particle Remodeling Cellular Response To Nitrogen Starvation Protein-containing Complex Remodeling Cellular Component Assembly Regulation Of Proteolysis Cytoplasmic Vesicle Beta-tubulin Binding Vacuole Organization Chylomicron Phosphatidylethanolamine Binding Low-density Lipoprotein Particle Chylomicron Remnant Negative Regulation Of Transport Locomotory Exploration Behavior Lipoprotein Particle Low-density Lipoprotein Particle Remodeling COPI-coated Vesicle Membrane Endocytosis Regulation Of Small Molecule Metabolic Process Regulation Of Neuronal Synaptic Plasticity Import Into Cell Cytosol Golgi Membrane Growth Cone Establishment Of Protein Localization Regulation Of Protein Catabolic Process Protein Transport Establishment Of Localization In Cell Cellular Response To Nutrient Levels Low-density Lipoprotein Particle Receptor Binding Regulation Of Long-term Neuronal Synaptic Plasticity Astrocyte Activation Involved In Immune Response Plasma Lipoprotein Particle Clearance Autophagosome Neutral Lipid Metabolic Process Cholesterol Efflux Microglial Cell Activation Positive Regulation Of Inflammatory Response Chylomicron Remnant Clearance Triglyceride-rich Lipoprotein Particle Clearance	Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Regulation Of Norepinephrine Uptake Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Protein Localization Retrograde Transporter Complex, Golgi To ER Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Oxidoreductase Activity Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Negative Regulation Of Dopamine Metabolic Process Regulation Of Serotonin Uptake Ascending Aorta Morphogenesis Pro-B Cell Differentiation Transporter Complex Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process Regulation Of Transport Atrial Septum Primum Morphogenesis Dopamine Uptake Involved In Synaptic Transmission Mitochondrial ATP Synthesis Coupled Electron Transport Cuprous Ion Binding Regulation Of Chaperone-mediated Autophagy Cellular Response To Oxidative Stress Response To Iron(II) Ion Dopamine Biosynthetic Process Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Transport Negative Regulation Of Cellular Respiration Negative Regulation Of Oxidative Phosphorylation Positive Regulation Of Gamma-delta T Cell Differentiation Noradrenergic Neuron Differentiation Mitral Valve Morphogenesis Catecholamine Uptake Dopamine Uptake Regulation Of Protein Localization Regulation Of Acyl-CoA Biosynthetic Process Positive Regulation Of Inositol Phosphate Biosynthetic Process Supramolecular Fiber Positive Regulation Of Gamma-delta T Cell Activation Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Protein Transport