RBM22 and RNU6-1

Number of citations: 60 (PubMedID 22246180)
Data Source: BioGRID (unspecified method)

		RBM22	RNU6-1
Name		RNA binding motif protein 22	RNA, U6 small nuclear 1
Structure			No pdb structure
GO Annotations	Cellular Component	Prp19 Complex Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm U2-type Catalytic Step 1 Spliceosome U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome	U6 SnRNP U4/U6 X U5 Tri-snRNP Complex
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding Zinc Ion Binding U6 SnRNA Binding Pre-mRNA Binding Metal Ion Binding Calcium-dependent Protein Binding	U4 SnRNA Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Positive Regulation Of RNA Splicing Positive Regulation Of Protein Import Into Nucleus MRNA Cis Splicing, Via Spliceosome Positive Regulation Of Protein Export From Nucleus Cellular Response To Xenobiotic Stimulus	Spliceosomal Tri-snRNP Complex Assembly Formation Of Quadruple SL/U4/U5/U6 SnRNP
Pathways		mRNA Splicing - Major Pathway	None
GWAS		Cholangiocarcinoma in primary sclerosing cholangitis ( 28779025 ) Crohn's disease ( 28067908 ) Inflammatory bowel disease ( 28067908 )	Cognitive performance ( 20125193 ) Cryptococcosis in HIV infection ( 33269293 )
Interacting Genes		45 interacting genes: AQR BAG4 BCAS2 BICD2 BMI1 CEBPA CEP55 CTBP1 CYSRT1 DMRTB1 EIF4ENIF1 ESS2 EXOSC7 EXOSC8 GIGYF1 GOLGA2 HNRNPUL1 HOMER3 HOOK1 KRT31 NCKIPSD NOA1 NXF1 OGT PQBP1 PRC1 PRMT2 PRNP PRPF39 PRPF6 RBFOX2 RBM4 RBPMS RNU6-1 RNU6-50P RNU6-6P SNRPA SNW1 TFIP11 TXNL4A VIM WBP4 YBX2 YTHDF1 YTHDF3	4 interacting genes: METTL16 RBM22 SND1 USB1
Entrez ID		55696	26827
HPRD ID		10186	Not available
Ensembl ID		ENSG00000086589	ENSG00000206625
Uniprot IDs		Q9NW64	Not available
PDB IDs		2YTC 5MQF 5XJC 5YZG 5Z56 5Z57 6FF4 6FF7 6ICZ 6ID0 6ID1 6QDV 6ZYM 7A5P 7AAV 7ABG 7ABI 7QTT 7W59 7W5A 7W5B 8C6J 8CH6 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 8RO2 9FMD	Not available
GO Terms Enriched among Interactors		RNA Splicing MRNA Metabolic Process MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing Spliceosomal Complex RNA Binding RNA Metabolic Process Catalytic Step 2 Spliceosome Regulation Of MRNA Metabolic Process Cytoplasmic Stress Granule MRNA Binding Nuclear Speck Nucleic Acid Metabolic Process U4/U6 X U5 Tri-snRNP Complex Membraneless Organelle Assembly U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Nucleus Identical Protein Binding Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleoplasm U2-type Catalytic Step 2 Spliceosome Cellular Component Assembly Exoribonuclease Complex Regulation Of RNA Splicing Nucleic Acid Binding P-body Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRAMP-dependent TRNA Surveillance Pathway TRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Translational Initiation U4 SnRNA 3'-end Processing Regulation Of Long-term Synaptic Potentiation Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Translational Initiation Memory RRNA 3'-end Processing Nucleolar Exosome (RNase Complex) U2-type Precatalytic Spliceosome TRNA Decay Nuclear MRNA Surveillance Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of MRNA Processing Pre-mRNA Intronic Binding	RNA Metabolic Process SnRNA Processing SnRNA Metabolic Process RNAi Effector Complex Nucleic Acid Metabolic Process MRNA Metabolic Process SnRNA (adenine-N6)-methylation U6 SnRNA (adenine-(43)-N(6))-methyltransferase Activity Poly(U)-specific Exoribonuclease Activity, Producing 3' Uridine Cyclic Phosphate Ends Nuclease Activity MRNA Catabolic Process Nucleobase-containing Compound Metabolic Process RNA Processing U6 SnRNA 3'-end Binding U6 SnRNA 3'-end Processing Regulation Of RNA Splicing MRNA M(6)A Methyltransferase Activity RNA Catabolic Process S-adenosylmethionine Biosynthetic Process RISC Complex Binding Dense Body SnRNA Modification Negative Regulation Of 3'-UTR-mediated MRNA Stabilization RRNA Base Methylation RNA Binding Nucleobase-containing Compound Catabolic Process MiRNA Catabolic Process RNA Splicing U2-type Catalytic Step 1 Spliceosome S-adenosylmethionine Metabolic Process U6 SnRNA Binding Prp19 Complex MRNA Cis Splicing, Via Spliceosome MRNA Processing RNA Stem-loop Binding Pre-mRNA Binding Positive Regulation Of Protein Export From Nucleus MiRNA Metabolic Process RRNA Methylation SnRNA 3'-end Processing Macromolecule Metabolic Process Nucleic Acid Binding U2-type Catalytic Step 2 Spliceosome 3'-5'-RNA Exonuclease Activity RRNA Modification RNA Endonuclease Activity Regulation Of Protein Export From Nucleus Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of RNA Splicing Regulation Of Protein Import Into Nucleus