PRKACG and TNP1

Number of citations: 0 (PubMedID 9837753)
Data Source: BioGRID (enzymatic study)

		PRKACG	TNP1
Name		protein kinase cAMP-activated catalytic subunit gamma	transition protein 1
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol CAMP-dependent Protein Kinase Complex Ciliary Base	Nucleosome Male Germ Cell Nucleus Nucleus Chromosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase A Regulatory Subunit Binding Protein Serine Kinase Activity	DNA Binding Protein Binding
	Biological Process	Renal Water Homeostasis Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Spermatogenesis Male Gonad Development High-density Lipoprotein Particle Assembly Vascular Endothelial Cell Response To Laminar Fluid Shear Stress	Single Strand Break Repair Nucleosome Disassembly Chromatin Remodeling Spermatogenesis Spermatid Development Spermatid Nucleus Differentiation Spermatid Nucleus Elongation Positive Regulation Of Protein Processing Sexual Reproduction Cell Differentiation Flagellated Sperm Motility Heterochromatin Formation Sperm DNA Decondensation Sperm DNA Condensation Negative Regulation Of DNA-templated Transcription
Pathways		PKA-mediated phosphorylation of CREB PKA-mediated phosphorylation of key metabolic factors Triglyceride catabolism PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Regulation of insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins VEGFA-VEGFR2 Pathway CREB1 phosphorylation through the activation of Adenylate Cyclase CREB1 phosphorylation through the activation of Adenylate Cyclase Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'off' state CD209 (DC-SIGN) signaling MAPK6/MAPK4 signaling RET signaling HDL assembly ROBO receptors bind AKAP5 GPER1 signaling GPER1 signaling Regulation of glycolysis by fructose 2,6-bisphosphate metabolism ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	None
GWAS		Metabolite levels ( 23823483 ) Night sleep phenotypes ( 27126917 )	Carboplatin disposition in epthelial ovarian cancer ( 29367611 ) Chronic kidney disease ( 31152163 ) Creatinine levels ( 29403010 ) Estimated glomerular filtration rate ( 31152163 ) Glomerular filtration rate ( 29403010 ) Height ( 25282103 31562340 ) Hypothyroidism ( 27182965 ) Mitral valve prolapse ( 26301497 ) Permanent tooth development ( 21931568 ) Pulse pressure ( 27841878 ) Thyroid stimulating hormone levels ( 32769997 )
Interacting Genes		4 interacting genes: CDK17 CETP TNP1 TNP2	10 interacting genes: CSNK2A1 DVL3 PPARA PPARD PPARG PRKACA PRKACB PRKACG PRKCA SDCBP2
Entrez ID		5568	7141
HPRD ID		01483	01830
Ensembl ID		ENSG00000165059	ENSG00000118245
Uniprot IDs		P22612	P09430 Q4ZG82
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Positive Regulation Of Protein Processing Sperm DNA Condensation Positive Regulation Of Protein Maturation Regulation Of Protein Processing Regulation Of Protein Maturation Sperm DNA Decondensation Nucleosome Triglyceride Transport Triglyceride Binding Positive Regulation Of Proteolysis Spermatid Nucleus Elongation Very-low-density Lipoprotein Particle Remodeling Triglyceride-rich Lipoprotein Particle Remodeling Spermatid Nucleus Differentiation Penetration Of Zona Pellucida Low-density Lipoprotein Particle Remodeling Phospholipid Homeostasis Phospholipid Transporter Activity Positive Regulation Of Phospholipid Transport Reverse Cholesterol Transport Negative Regulation Of Macrophage Derived Foam Cell Differentiation Sexual Reproduction Single Strand Break Repair Regulation Of Proteolysis Acrosome Reaction High-density Lipoprotein Particle Remodeling Male Gamete Generation Nucleosome Disassembly Spermatogenesis High-density Lipoprotein Particle Cholesterol Transfer Activity Gamete Generation Protein-DNA Complex Disassembly Cyclin-dependent Protein Serine/threonine Kinase Activity Phosphatidylcholine Binding Regulation Of Macrophage Derived Foam Cell Differentiation Plasma Lipoprotein Particle Remodeling Positive Regulation Of Cholesterol Transport Protein-containing Complex Remodeling Chromosome Triglyceride Homeostasis Acylglycerol Homeostasis Regulation Of Cholesterol Efflux Cholesterol Binding Male Germ Cell Nucleus Positive Regulation Of Protein Metabolic Process	CAMP-dependent Protein Kinase Activity Negative Regulation Of Cholesterol Storage CAMP-dependent Protein Kinase Complex High-density Lipoprotein Particle Assembly Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Intracellular Signal Transduction Vascular Endothelial Cell Response To Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Renal Water Homeostasis Negative Regulation Of Lipid Storage Response To Laminar Fluid Shear Stress Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Negative Regulation Of MiRNA Transcription Renal System Process Multicellular Organismal-level Water Homeostasis Cellular Response To Fluid Shear Stress Protein Serine Kinase Activity Regulation Of Biological Quality Positive Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Lipid Metabolic Process Positive Regulation Of Protein Secretion Positive Regulation Of Hormone Secretion Positive Regulation Of Small Molecule Metabolic Process Ciliary Base Response To Fluid Shear Stress Protein Serine/threonine Kinase Activity Regulation Of Lipid Storage Regulation Of Intracellular Signal Transduction Nuclear Receptor Activity Response To Nutrient Levels Signal Transduction Protein Kinase Activity Multicellular Organismal-level Chemical Homeostasis Regulation Of Cardiac Muscle Hypertrophy Cellular Response To Stress Regulation Of Muscle System Process Positive Regulation Of Protein Transport Regulation Of MiRNA Transcription Cellular Response To Nutrient Levels Regulation Of Hormone Secretion Regulation Of Protein Secretion Positive Regulation Of Insulin Secretion Regulation Of MiRNA Metabolic Process Regulation Of Body Fluid Levels Kinase Activity Peroxisome Proliferator Activated Receptor Signaling Pathway Positive Regulation Of Secretion By Cell Negative Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Fatty Acid Metabolic Process