IWS1 and ERICH2

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		IWS1	ERICH2
Name		interacts with SUPT6H, CTD assembly factor 1	glutamate rich 2
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	None
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	In Utero Embryonic Development Chromatin Remodeling MRNA Processing RNA Splicing Regulation Of MRNA Export From Nucleus Poly(A)+ MRNA Export From Nucleus Regulation Of MRNA Processing MRNA Transport Transcription Elongation-coupled Chromatin Remodeling	None
Pathways		Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation	None
GWAS		Cardiac troponin-I levels ( 31014085 )	Metabolic syndrome ( 31589552 ) Triglyceride levels ( 32203549 )
Interacting Genes		10 interacting genes: AKT1 AKT3 CSNK2A1 ERCC6 ERICH2 KRTAP10-3 POLR2A STAT2 SUPT6H TCEA1	5 interacting genes: FBXO7 IWS1 MACROH2A1 PSORS1C2 SDCBP
Entrez ID		55677	285141
HPRD ID		07639	Not available
Ensembl ID		ENSG00000163166	ENSG00000204334
Uniprot IDs		A0A1B0GW95 Q96ST2	A0A8V8TMA0 A0A8V8TMB5 A1L162
PDB IDs		6EMR 6ZV1 6ZV4 9EGX 9EGY 9EGZ 9EH0 9EH1 9EH2	Not available
GO Terms Enriched among Interactors		DNA-templated Transcription Elongation Transcription Elongation By RNA Polymerase II Negative Regulation Of PERK-mediated Unfolded Protein Response Double-strand Break Repair Via Classical Nonhomologous End Joining RNA Metabolic Process Regulation Of PERK-mediated Unfolded Protein Response Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of DNA Recombination Sin3-type Complex Transcription Elongation Factor Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Execution Phase Of Apoptosis Regulation Of Peptidyl-serine Phosphorylation Regulation Of DNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Response To Stress Negative Regulation Of Double-strand Break Repair Negative Regulation Of DNA Repair Negative Regulation Of Translational Initiation Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Response To Endoplasmic Reticulum Stress Nucleoplasm Regulation Of TRNA Methylation Positive Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Blood Vessel Endothelial Cell Migration Nucleic Acid Metabolic Process Positive Regulation Of DNA-templated Transcription, Elongation Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Response To Insulin-like Growth Factor Stimulus Regulation Of Blood Vessel Endothelial Cell Migration Protein Serine Kinase Activity Mammalian Oogenesis Stage Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Regulation Of Gene Expression Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Regulation Of Cell Cycle Phase Transition Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Kinase Binding	Interleukin-5 Receptor Complex Protein Heterodimerization Activity Negative Regulation Of Protein Localization To Chromosome, Telomeric Region Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Interleukin-5 Receptor Binding ADP-D-ribose Binding Regulation Of NAD Metabolic Process Regulation Of RDNA Heterochromatin Formation Positive Regulation Of Endodermal Cell Differentiation Positive Regulation Of Response To Oxidative Stress ADP-D-ribose Modification-dependent Protein Binding Lewy Body Core Positive Regulation Of Extracellular Exosome Assembly Syndecan Binding Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Protein Targeting Regulation Of Extracellular Exosome Assembly Poly-ADP-D-ribose Modification-dependent Protein Binding RDNA Binding Sex Chromatin Negative Regulation Of Cell Cycle Phase Transition Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Double-stranded Methylated DNA Binding Barr Body Transcription Elongation-coupled Chromatin Remodeling Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Process Negative Regulation Of Response To Oxidative Stress Establishment Of Protein Localization To Chromatin Regulation Of Heterochromatin Formation Substrate-dependent Cell Migration, Cell Extension Negative Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Sister Chromatid Cohesion Regulation Of MRNA Export From Nucleus Establishment Of Protein Localization Establishment Of Protein Localization To Organelle Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Negative Regulation Of Cell Cycle Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Exosomal Secretion Negative Regulation Of Receptor Internalization Regulation Of Sister Chromatid Cohesion Protein Poly-ADP-ribosylation Regulation Of RNA Export From Nucleus Regulation Of Exosomal Secretion Positive Regulation Of Keratinocyte Differentiation Cytoskeletal Anchor Activity