NHP2 and MYL2

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		NHP2	MYL2
Name		NHP2 ribonucleoprotein	myosin light chain 2
Structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Telomerase Holoenzyme Complex Nucleolus Sno(s)RNA-containing Ribonucleoprotein Complex Cajal Body Box H/ACA SnoRNP Complex Box H/ACA ScaRNP Complex Box H/ACA Telomerase RNP Complex Ribonucleoprotein Complex	Cytoplasm Cytosol Cytoskeleton Actin Cytoskeleton Myosin Complex Myofibril Sarcomere A Band Cardiac Myofibril
	Molecular Function	RNA Binding MRNA 3'-UTR Binding Protein Binding U3 SnoRNA Binding Box H/ACA SnoRNA Binding Telomerase RNA Binding	Actin Monomer Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Myosin Heavy Chain Binding Metal Ion Binding
	Biological Process	SnoRNA Guided RRNA Pseudouridine Synthesis RRNA Processing Telomere Maintenance Via Telomerase RRNA Pseudouridine Synthesis SnRNA Pseudouridine Synthesis Ribosome Biogenesis Telomerase RNA Localization To Cajal Body	Regulation Of The Force Of Heart Contraction Heart Morphogenesis Regulation Of Striated Muscle Contraction Heart Development Post-embryonic Development Negative Regulation Of Cell Growth Muscle Cell Fate Specification Muscle Cell Development Cardiac Myofibril Assembly Ventricular Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction Positive Regulation Of The Force Of Heart Contraction
Pathways		Telomere Extension By Telomerase rRNA modification in the nucleus and cytosol	Striated Muscle Contraction
Diseases		Dyskeratosis congenita (DC), including: X-linked dyskeratosis congenita (DKCX); Autosomal dominant dyskeratosis congenita (DKCA1); Autosomal recessive dyskeratosis congenita (DKCB1)	Hypertrophic cardiomyopathy (HCM)
GWAS		Platelet count ( 29403010 )	Alcohol consumption ( 21270382 ) Alcohol consumption (drinkers vs non-drinkers) ( 28485404 ) Alcohol consumption (max-drinks) ( 29460428 ) Body mass index ( 24861553 ) Coffee consumption ( 29367735 ) Coronary heart disease ( 23364394 ) Drinking behavior ( 23364009 ) Gamma glutamyl transpeptidase ( 21909109 ) Glycemic traits ( 23575436 ) Gout ( 25646370 ) HDL cholesterol ( 21909109 ) HDL cholesterol levels ( 28334899 ) High density lipoprotein cholesterol levels ( 30718733 ) Hypertension ( 32709000 ) Metabolic syndrome ( 25705158 ) Metabolic syndrome (multivariate analysis) ( 29632305 ) Neutrophil count ( 29403010 ) Serum uric acid levels ( 32514006 ) Urate levels ( 31578528 ) White blood cell count ( 29403010 )
Interacting Genes		10 interacting genes: IKBKG JMJD6 MYL2 NEDD4 NEDD4L NOS1AP PRNP RSPH1 UBE2I UTP23	12 interacting genes: CDC42BPA GJB5 LRSAM1 MYOC NHP2 PAK2 PKM PPP1R12C PSORS1C2 TRIM63 USP6 ZNF529
Entrez ID		55651	4633
HPRD ID		07570	01181
Ensembl ID		ENSG00000145912	ENSG00000111245
Uniprot IDs		J3QSY4 Q9NX24	A0A590UJU8 G3V1V8 P10916 Q6IB42
PDB IDs		7BGB 7TRC 7V9A 8OUE 8OUF	5TBY 8ACT 8G4L
GO Terms Enriched among Interactors		Regulation Of Potassium Ion Transmembrane Transport Regulation Of Potassium Ion Transport Negative Regulation Of Potassium Ion Export Across Plasma Membrane Sodium Channel Inhibitor Activity Regulation Of Monoatomic Cation Transmembrane Transport Potassium Channel Inhibitor Activity Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Sodium Ion Transport Regulation Of Metal Ion Transport Transmembrane Transporter Binding Receptor Catabolic Process Regulation Of Monoatomic Ion Transport Negative Regulation Of Potassium Ion Transmembrane Transport Postsynaptic Cytosol Negative Regulation Of Potassium Ion Transport Cytosol Neuromuscular Junction Development Regulation Of Membrane Repolarization Receptor Metabolic Process Regulation Of T Cell Receptor Signaling Pathway Muscle Cell Fate Specification Regulation Of Dendrite Morphogenesis Regulation Of Synapse Organization Protein Monoubiquitination Formation Of Structure Involved In A Symbiotic Process Type 8 Metabotropic Glutamate Receptor Binding SUMO Conjugating Enzyme Activity Histone H4R3 Demethylase Activity Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Peptidyl-lysine 5-dioxygenase Activity Histone H3R2 Demethylase Activity Oxidative RNA Demethylation Receptor Internalization Negative Regulation Of Cation Transmembrane Transport Regulation Of Sodium Ion Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Cellular Component Assembly Signaling Adaptor Activity Channel Inhibitor Activity Ubiquitin Ligase Complex Regulation Of Membrane Potential Phosphothreonine Residue Binding Negative Regulation Of Monoatomic Ion Transport Regulation Of Dendrite Development RING-like Zinc Finger Domain Binding Linear Polyubiquitin Binding Positive Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Protein Homooligomerization	Skeletal Muscle Adaptation Muscle Hypertrophy Negative Regulation Of Stress Fiber Assembly Rough Endoplasmic Reticulum Negative Regulation Of Actin Filament Bundle Assembly Muscle System Process Skeletal Muscle Hypertrophy