PNRC2 and RORA

Number of citations: 0 (PubMedID 15604093)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		PNRC2	RORA
Name		proline rich nuclear receptor coactivator 2	RAR related orphan receptor A
Structure
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol	Chromatin Nucleus Nucleoplasm Nucleolus
	Molecular Function	Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding Transcription Corepressor Binding Transcription Coactivator Binding DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Beta-catenin Binding Oxysterol Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Ligand-modulated Transcription Factor Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Metabolic Process Deadenylation-independent Decapping Of Nuclear-transcribed MRNA	Angiogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Xenobiotic Metabolic Process Nitric Oxide Biosynthetic Process Circadian Rhythm Regulation Of Smoothened Signaling Pathway Regulation Of Gene Expression Positive Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Glucose Metabolic Process Regulation Of Steroid Metabolic Process Cerebellar Purkinje Cell Differentiation Cerebellar Granule Cell Precursor Proliferation Intracellular Receptor Signaling Pathway Circadian Regulation Of Gene Expression Cellular Response To Sterol Cholesterol Homeostasis Muscle Cell Differentiation Regulation Of Circadian Rhythm Positive Regulation Of Circadian Rhythm Regulation Of Macrophage Activation Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Fat Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II CGMP Metabolic Process Rhythmic Process Negative Regulation Of Inflammatory Response Triglyceride Homeostasis Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia T-helper 17 Cell Differentiation
Pathways		Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	PPARA activates gene expression Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Interleukin-4 and Interleukin-13 signaling Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Drugs		None	Cholesterol sulfate Cholesterol
GWAS		Obesity-related traits ( 23251661 )	A body shape index ( 34021172 ) Adult asthma ( 30787307 ) Adult body size ( 32376654 ) Alanine aminotransferase levels ( 33547301 ) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359 ) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359 ) Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Allergic rhinitis ( 30013184 ) Allergic sensitization ( 30013184 ) Apolipoprotein A1 levels ( 32203549 ) Aspartate aminotransferase levels ( 33547301 ) Asthma ( 31619474 29273806 30929738 31959851 27182965 32296059 31361310 34103634 20860503 ) Asthma (adult onset) ( 30929738 ) Asthma (age of onset) ( 31036433 ) Asthma (childhood onset) ( 30929738 31036433 ) Asthma (moderate or severe) ( 30552067 ) Asthma (time to onset) ( 27130862 ) Asthma onset (childhood vs adult) ( 30929738 ) Birth weight ( 31043758 ) Blood urea nitrogen levels ( 29403010 31152163 ) Body mass index ( 28892062 ) Breast cancer (prognosis) ( 23319801 ) C-reactive protein levels ( 30388399 21300955 ) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809 ) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809 ) Caffeine consumption from coffee or tea ( 33287642 ) Caffeine consumption from tea ( 33287642 ) Cataracts ( 34127677 ) Cerebrospinal fluid beta-site APP cleaving enzyme levels ( 29751835 ) Chronic central serous retinopathy ( 30073298 ) Depression (quantitative trait) ( 20800221 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Eosinophilic esophagitis ( 34506852 ) Gamma glutamyl transferase levels ( 22010049 ) Glaucoma (primary open-angle) ( 33627673 ) Height ( 31562340 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) High density lipoprotein cholesterol levels ( 31211820 ) High light scatter reticulocyte count ( 32888494 ) Hip circumference adjusted for BMI ( 28552196 ) Intraocular pressure ( 29617998 ) Keratoconus ( 33649486 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 22001757 ) Male-pattern baldness ( 28196072 ) Mean spheric corpuscular volume ( 32888494 ) Medication use (adrenergics, inhalants) ( 31015401 ) Medication use (glucocorticoids) ( 31015401 ) Menarche (age at onset) ( 21102462 23599027 25231870 ) Multiple sclerosis ( 31604244 ) Neuropathic pain in head and neck cancer ( 29884837 ) Nickel levels ( 26025379 ) Offspring birth weight ( 31043758 ) Pulmonary function decline ( 22424883 ) Red blood cell count ( 32888494 ) Refractive error ( 32231278 ) Response to citalopram treatment ( 19846067 ) Reticulocyte count ( 32888494 ) Schizophrenia ( 23212062 ) Subcutaneous adipose tissue ( 22589738 ) Total ventricular volume (Alzheimer's disease interaction) ( 21116278 ) Triglyceride levels ( 32203549 32154731 ) Waist circumference adjusted for body mass index ( 34021172 )
Interacting Genes		23 interacting genes: APP AR BANP DCP1A ESR1 ESR2 ESRRA ESRRG FBXO7 GALK1 GLOD4 HNF4A HNF4G NR5A1 NR5A2 RARA RARG RORA RORB SPAG9 XRCC6 ZBTB16 ZBTB48	24 interacting genes: BHLHE41 COPS5 CSNK1E EP300 GFAP HIF1A ITCH LMO3 LRIF1 MED1 MYOD1 NCOA1 NCOA2 NME1 NME2 NR0B1 NSD1 PNRC1 PNRC2 PROX1 PSMC5 SMARCD3 SP1 ZXDC
Entrez ID		55629	6095
HPRD ID		17871	02896
Ensembl ID		ENSG00000189266	ENSG00000069667
Uniprot IDs		Q9NPJ4	A0A0C4DFP5 A0A0C4DG53 P35398
PDB IDs		4B6H 5KQ1 5KQ4	1N83 1S0X 4S15
GO Terms Enriched among Interactors		Nuclear Receptor Activity Intracellular Receptor Signaling Pathway Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Positive Regulation Of Transcription By RNA Polymerase II Hormone-mediated Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA Binding Positive Regulation Of RNA Metabolic Process Estrogen Response Element Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor-mediated Signaling Pathway Nuclear Steroid Receptor Activity Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II Steroid Binding Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Signal Transduction Positive Regulation Of Biosynthetic Process Zinc Ion Binding Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Chromatin Binding Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription Coregulator Binding Regulation Of Developmental Process Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Transcription Coactivator Binding Metal Ion Binding Regulation Of Macromolecule Biosynthetic Process Rhythmic Process Transcription Cis-regulatory Region Binding Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Estrogen Stimulus Regulation Of Cell Differentiation Cellular Response To Lipid	Nuclear Receptor Binding Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Chromatin Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Coactivator Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Retinoic Acid Receptor Binding Regulation Of RNA Metabolic Process Transcription Coregulator Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Rhythmic Process Positive Regulation Of Developmental Process Positive Regulation Of Metabolic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Lactation Positive Regulation Of Epithelial Cell Proliferation Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Developmental Process Positive Regulation Of Multicellular Organismal Process Nucleoplasm Circadian Rhythm Negative Regulation Of Macromolecule Biosynthetic Process ITP Biosynthetic Process Protein Histidine Kinase Activity Negative Regulation Of Biosynthetic Process Transcription By RNA Polymerase II Chromatin Binding Body Fluid Secretion DNA-binding Transcription Factor Binding Protein Dimerization Activity Regulation Of Small Molecule Metabolic Process DNA-binding Transcription Activator Activity Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Response To Thyroglobulin Triiodothyronine