NAGK and ACTR10

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		NAGK	ACTR10
Name		N-acetylglucosamine kinase	actin related protein 10
Structure			No pdb structure
GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Extracellular Region Cytoplasm Cytosol Cytoskeleton Dynactin Complex Azurophil Granule Lumen Axon Cytoplasm Ficolin-1-rich Granule Lumen
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding N-acylmannosamine Kinase Activity Kinase Activity Transferase Activity N-acetylglucosamine Kinase Activity Muramyl Dipeptide Kinase Activity	Protein Binding
	Biological Process	Immune System Process N-acetylglucosamine Metabolic Process N-acetylglucosamine Catabolic Process UDP-N-acetylglucosamine Biosynthetic Process N-acetylmannosamine Metabolic Process Canonical NF-kappaB Signal Transduction N-acetylneuraminate Catabolic Process Response To Muramyl Dipeptide P38MAPK Cascade Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Carbohydrate Phosphorylation Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein K63-linked Ubiquitination Protein Linear Polyubiquitination	Microtubule-based Movement Retrograde Axonal Transport Of Mitochondrion
Pathways		Synthesis of UDP-N-acetyl-glucosamine	MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Neutrophil degranulation COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic
Drugs		N-Acetylglucosamine	None
GWAS		Blood protein levels ( 30072576 ) Erythema nodosum in inflammatory bowel disease ( 24487271 )	Alcohol consumption ( 31358974 ) Brain morphology (MOSTest) ( 32665545 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 )
Interacting Genes		36 interacting genes: ACTR10 ANKRD1 CCDC158 CDKN2C CEP43 DACH1 DCP2 DSCR9 DYNC1I1 FNDC3B GNPNAT1 LACTB2 LENG1 LMO1 LNX1 LNX2 LSM8 MEOX1 MTHFD2 NTAQ1 NUDC PJA1 PKM PPHLN1 REL SDCBP SF3B3 SMAD2 SMAD9 SPRED1 SRPK2 STK16 SYNE4 TCF12 TNNT1 WDR82	7 interacting genes: ACTA1 DCTN4 HOMEZ KRT31 NAGK RXFP4 SLC13A1
Entrez ID		55577	55860
HPRD ID		08441	12420
Ensembl ID		ENSG00000124357	ENSG00000131966
Uniprot IDs		A0A384N6G7 C9JEV6 Q9UJ70	Q9NZ32
PDB IDs		2CH5 2CH6	Not available
GO Terms Enriched among Interactors		Nucleoplasm Transcription Regulator Complex Negative Regulation Of DNA Biosynthetic Process Heteromeric SMAD Protein Complex SMAD Protein Complex Cytoplasm Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process HMG Box Domain Binding Nucleus Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process I-SMAD Binding Response To Transforming Growth Factor Beta Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Nucleobase-containing Compound Metabolic Process	Structural Constituent Of Cytoskeleton Sarcomere Stress Fiber Sodium:sulfate Symporter Activity Monoatomic Anion:sodium Symporter Activity N-acetylglucosamine Kinase Activity N-acylmannosamine Kinase Activity N-acetylmannosamine Metabolic Process Muramyl Dipeptide Kinase Activity Skeletal Muscle Thin Filament Assembly Mesenchyme Migration Protein Linear Polyubiquitination Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway N-acetylglucosamine Catabolic Process N-acetylneuraminate Catabolic Process Galanin Receptor Activity Secondary Active Sulfate Transmembrane Transporter Activity Dynactin Complex Striated Muscle Thin Filament Sulfate Transmembrane Transport UDP-N-acetylglucosamine Biosynthetic Process Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway N-acetylneuraminate Metabolic Process Positive Regulation Of Feeding Behavior Solute:sodium Symporter Activity UDP-N-acetylglucosamine Metabolic Process Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway