NAGK and CEP43

Number of citations: 0 (PubMedID 21900206)
Data Source: BioGRID (two hybrid)

		NAGK	CEP43
Name		N-acetylglucosamine kinase	centrosomal protein 43
Structure
GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Nucleus Cytoplasm Centrosome Centriole Microtubule Organizing Center Cytosol Cytoskeleton Microtubule Cytoskeleton Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding N-acylmannosamine Kinase Activity Kinase Activity Transferase Activity N-acetylglucosamine Kinase Activity Muramyl Dipeptide Kinase Activity	Protein Binding Protein Kinase Binding Protein Tyrosine Kinase Inhibitor Activity Protein Homodimerization Activity
	Biological Process	Immune System Process N-acetylglucosamine Metabolic Process N-acetylglucosamine Catabolic Process UDP-N-acetylglucosamine Biosynthetic Process N-acetylmannosamine Metabolic Process Canonical NF-kappaB Signal Transduction N-acetylneuraminate Catabolic Process Response To Muramyl Dipeptide P38MAPK Cascade Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Carbohydrate Phosphorylation Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein K63-linked Ubiquitination Protein Linear Polyubiquitination	Negative Regulation Of Protein Kinase Activity Positive Regulation Of Cell Population Proliferation Cell Projection Organization Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Microtubule Anchoring
Pathways		Synthesis of UDP-N-acetyl-glucosamine	Signaling by cytosolic FGFR1 fusion mutants Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Signaling by FGFR1 in disease AURKA Activation by TPX2
Drugs		N-Acetylglucosamine	None
GWAS		Blood protein levels ( 30072576 ) Erythema nodosum in inflammatory bowel disease ( 24487271 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: ELP4	4 novel interactors: LINC01558 RNASET2 TBP TCP10L3
Interacting Genes		36 interacting genes: ACTR10 ANKRD1 CCDC158 CDKN2C CEP43 DACH1 DCP2 DSCR9 DYNC1I1 FNDC3B GNPNAT1 LACTB2 LENG1 LMO1 LNX1 LNX2 LSM8 MEOX1 MTHFD2 NTAQ1 NUDC PJA1 PKM PPHLN1 REL SDCBP SF3B3 SMAD2 SMAD9 SPRED1 SRPK2 STK16 SYNE4 TCF12 TNNT1 WDR82	4 interacting genes: NAGK OGT PPP2R1B S100A6
Entrez ID		55577	11116
HPRD ID		08441	10392
Ensembl ID		ENSG00000124357	ENSG00000213066
Uniprot IDs		A0A384N6G7 C9JEV6 Q9UJ70	A0A087WV25 B4DH64 O95684
PDB IDs		2CH5 2CH6	2D68
GO Terms Enriched among Interactors		Nucleoplasm Transcription Regulator Complex Negative Regulation Of DNA Biosynthetic Process Heteromeric SMAD Protein Complex SMAD Protein Complex Cytoplasm Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process HMG Box Domain Binding Nucleus Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process I-SMAD Binding Response To Transforming Growth Factor Beta Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Nucleobase-containing Compound Metabolic Process	Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Ribonuclease T2 Activity N-acetylglucosamine Kinase Activity Muramyl Dipeptide Kinase Activity