PPP6C and TIPRL

Number of citations: 40 (PubMedID 36652389)
Data Source: BioGRID (affinity chromatography technology, pull down, cross-linking study, affinity chromatography technology)

		PPP6C	TIPRL
Name		protein phosphatase 6 catalytic subunit	TOR signaling pathway regulator
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytosol	Cytoplasm Cytosol
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Metal Ion Binding	Protein Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase Activator Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Immune System Process Protein Dephosphorylation Innate Immune Response COPII Vesicle Coating CGAS/STING Signaling Pathway Negative Regulation Of CGAS/STING Signaling Pathway	DNA Damage Checkpoint Signaling TOR Signaling
Pathways		Telomere Extension By Telomerase COPII-mediated vesicle transport	None
GWAS		Pulse pressure ( 27841878 ) Refractive error ( 32231278 ) Systolic blood pressure ( 27841878 30578418 )	LDL cholesterol levels in HIV infection ( 33109212 ) Red cell distribution width ( 32888494 )
Interacting Genes		7 interacting genes: AURKA IGBP1 NFKBIE TGFBR1 TIPRL VAC14 ZNRF2	6 interacting genes: APP CEBPA PPP2CB PPP4C PPP6C UFL1
Entrez ID		5537	261726
HPRD ID		02141	14608
Ensembl ID		ENSG00000119414	ENSG00000143155
Uniprot IDs		A0A024R861 O00743	O75663
PDB IDs		Not available	5D9G
GO Terms Enriched among Interactors		Peptidyl-serine Phosphorylation	Protein Serine/threonine Phosphatase Activity Phosphoprotein Phosphatase Activity Response To Lead Ion Positive Regulation Of Proteolysis Response To Stress Regulation Of Defense Response Positive Regulation Of Immune System Process Amyloid-beta Complex Growth Cone Lamellipodium Response To Metal Ion Positive Regulation Of Cell Activation Regulation Of Response To Calcium Ion Amylin Binding Regulation Of Proteolysis Positive Regulation Of Toll Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of Inflammatory Response Positive Regulation Of Defense Response RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding UFM1 Ligase Activity Protein Dephosphorylation Acetylcholine Receptor Activator Activity PTB Domain Binding Innate Immune Response Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Catabolic Process Regulation Of Immune System Process Regulation Of Cell Activation Endosome To Plasma Membrane Transport Vesicle Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Response To Endoplasmic Reticulum Stress Defense Response Macromolecule Metabolic Process Lipoprotein Particle Memory Regulation Of Cellular Response To Stress Notch Signaling Pathway Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Cell Communication Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Immune System Process CHOP-C/EBP Complex Cellular Response To Stress