PPP5C and CDC16

Number of citations: 0 (PubMedID 9405394)
Data Source: HPRD (two hybrid, in vitro)

		PPP5C	CDC16
Name		protein phosphatase 5 catalytic subunit	cell division cycle 16
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Protein-containing Complex Neuronal Cell Body Perikaryon Protein Folding Chaperone Complex Proximal Dendrite	Nucleus Nucleoplasm Anaphase-promoting Complex Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Mitotic Spindle
	Molecular Function	G-protein Alpha-subunit Binding RNA Binding Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding ATP Binding Microtubule Binding Lipid Binding Hydrolase Activity Phosphatase Activity Protein Serine/threonine Kinase Inhibitor Activity Hsp70 Protein Binding Heat Shock Protein Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Identical Protein Binding ADP Binding Protein-containing Complex Binding Metal Ion Binding Tau Protein Binding Hsp90 Protein Binding	Protein Binding
	Biological Process	MAPK Cascade Mitotic Cell Cycle DNA Repair Double-strand Break Repair DNA-templated Transcription DNA Damage Response Response To Lead Ion Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Morphine Negative Regulation Of MAPK Cascade Peptidyl-serine Dephosphorylation Cellular Response To Hydrogen Peroxide Cellular Response To Cadmium Ion Response To Arachidonate Positive Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway	Regulation Of Mitotic Cell Cycle Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Regulation Of Meiotic Cell Cycle Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Branched Polyubiquitination
Pathways		Negative regulation of MAPK pathway Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks ESR-mediated signaling	Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs		ATP	None
GWAS		Basophil percentage of white cells ( 27863252 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Crohn's disease ( 28067908 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Hemoglobin ( 32888494 ) Lymphocyte count ( 32888494 ) Neuroticism ( 29255261 ) Response to antidepressants in depression ( 29998114 ) Triglyceride levels ( 32203549 )	Appendicular lean mass ( 33097823 ) Hip circumference adjusted for BMI ( 34021172 ) Metabolite levels ( 23823483 ) Monocyte percentage of white cells ( 32888494 ) Prudent dietary pattern ( 28644415 ) Pulse pressure ( 27841878 ) Systolic blood pressure ( 27841878 30578418 )
Interacting Genes		30 interacting genes: APP BRWD1 CDC16 CDC27 CDC37 CDK20 CEBPA CHORDC1 CPNE1 CPNE2 CPNE4 CRY2 CSE1L CSNK1D DISC1 EGFR ESR2 GNA12 GNA13 HSP90AA1 HTR2A HUWE1 MAP3K5 MAP3K7 MAPT OGT PPP2R1A PPP2R3A SIM2 VHL	22 interacting genes: ANAPC10 ANAPC11 ANAPC7 BUB1B CDC20 CDC23 CDC27 CSTPP1 DAB2 DNAJA1 FTH1 HINT1 LINC00839 MAD2L1 MAPK9 MTNR1B PPP5C SKIL SMAD2 SMAD3 UBE2S XRCC5
Entrez ID		5536	8881
HPRD ID		02805	04587
Ensembl ID		ENSG00000011485	ENSG00000130177
Uniprot IDs		P53041	A0A3B3ISD2 B2RCW0 Q13042
PDB IDs		1A17 1S95 1WAO 2BUG 3H60 3H61 3H62 3H63 3H64 3H66 3H67 3H68 3H69 4ZVZ 4ZX2 5HPE 5UI1 5WG8 7ZR5 7ZR6 8GAE 8GFT	3HYM 4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5 6TNT 8PKP 8TAR 8TAU 9GAW
GO Terms Enriched among Interactors		Positive Regulation Of Catabolic Process Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Primary Metabolic Process Intracellular Signal Transduction Regulation Of Developmental Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication D5 Dopamine Receptor Binding Neurofibrillary Tangle Assembly Protein Branched Polyubiquitination Circadian Regulation Of Gene Expression Positive Regulation Of Signal Transduction Protein Serine/threonine Kinase Binding MAP Kinase Kinase Kinase Activity Protein Localization To Organelle Cellular Response To Metal Ion Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Signal Transduction Amyloid Fibril Formation Regulation Of Metabolic Process Response To Metal Ion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Phosphatase Binding Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Main Axon Kinase Binding Regulation Of Gene Expression Regulation Of Proteolysis Rho-activating G Protein-coupled Receptor Signaling Pathway Hsp90 Protein Binding Positive Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Memory Regulation Of Cell Cycle Nucleus Cytosol Cytoplasm Intracellular Signaling Cassette Circadian Rhythm Protein Localization To Cytoskeleton Positive Regulation Of Cell Differentiation	Anaphase-promoting Complex Anaphase-promoting Complex-dependent Catabolic Process Protein K11-linked Ubiquitination Protein Branched Polyubiquitination Regulation Of Sister Chromatid Segregation Regulation Of Mitotic Sister Chromatid Separation Metaphase/anaphase Transition Of Cell Cycle Regulation Of Meiotic Cell Cycle Regulation Of Chromosome Segregation Regulation Of Chromosome Organization Regulation Of Chromosome Separation Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Positive Regulation Of Mitotic Metaphase/anaphase Transition Mitotic Checkpoint Complex Regulation Of Mitotic Nuclear Division Positive Regulation Of Mitotic Sister Chromatid Separation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Nuclear Division Metaphase/anaphase Transition Of Mitotic Cell Cycle Positive Regulation Of Chromosome Separation Proteasomal Protein Catabolic Process Regulation Of Reproductive Process Regulation Of Mitotic Cell Cycle Protein K48-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Mitotic Nuclear Division Cytosol Protein Catabolic Process Regulation Of Organelle Organization Mitotic Cell Cycle Phase Transition Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Paraxial Mesoderm Morphogenesis Regulation Of Protein Ubiquitination Regulation Of Ubiquitin-protein Transferase Activity Mitotic Spindle Assembly Checkpoint Signaling Positive Regulation Of Mitotic Cell Cycle Phase Transition Post-translational Protein Modification Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Mitotic Metaphase/anaphase Transition Protein Ubiquitination Proteolysis Spindle Regulation Of Post-translational Protein Modification Positive Regulation Of Cell Cycle Phase Transition