PPP4C and IGBP1

Number of citations: 0 (PubMedID 9647778)
Data Source: HPRD (two hybrid)

		PPP4C	IGBP1
Name		protein phosphatase 4 catalytic subunit	immunoglobulin binding protein 1
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Protein Phosphatase 4 Complex	Cytoplasm Cytosol
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Metal Ion Binding	Protein Binding Protein Phosphatase Regulator Activity Protein Phosphatase 2A Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair	Negative Regulation Of Transcription By RNA Polymerase II Signal Transduction Regulation Of Signal Transduction Negative Regulation Of Stress-activated MAPK Cascade Response To Tumor Necrosis Factor Regulation Of Dephosphorylation Intracellular Signal Transduction B Cell Activation Regulation Of Microtubule-based Movement Response To Interleukin-1
Pathways		Processing of DNA double-strand break ends	None
Diseases		None	Corpus callosum, agenesis of, with mental retardation, ocular coloboma and micrognathia
GWAS		Adventurousness ( 30643258 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Body fat distribution (arm fat ratio) ( 30664634 ) Brain morphology (MOSTest) ( 32665545 ) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143 ) Eosinophil percentage of white cells ( 32888494 ) Mean corpuscular volume ( 29403010 ) Medication use (diuretics) ( 31015401 ) Schizophrenia ( 25056061 29483656 )	No GWAS studies recorded
Interacting Genes		21 interacting genes: CCDC6 DHX38 GPANK1 HDAC3 IGBP1 JUN NFKB1 PPP2R1A PPP2R5D PPP4R1 PPP4R2 PPP4R3B PPP4R4 REL RELA TIPRL TK1 TMSB4X TP53 TRAF6 UBE2D3	12 interacting genes: APP HSPB1 LINC01257 MID1 MID2 PPP2CA PPP4C PPP6C PYGM REXO5 S100A13 SHOX
Entrez ID		5531	3476
HPRD ID		03615	02140
Ensembl ID		ENSG00000149923	ENSG00000089289
Uniprot IDs		A0A024R625 P60510	P78318
PDB IDs		Not available	4IYP
GO Terms Enriched among Interactors		Protein Phosphatase Regulator Activity Tumor Necrosis Factor-mediated Signaling Pathway Protein Phosphatase 4 Complex Non-canonical NF-kappaB Signal Transduction General Transcription Initiation Factor Binding Canonical NF-kappaB Signal Transduction Positive Regulation Of MiRNA Metabolic Process NF-kappaB P50/p65 Complex Protein Phosphatase Activator Activity Chromatin Response To Muscle Stretch Regulation Of MiRNA Metabolic Process Enzyme Binding NF-kappaB Complex DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Histone Deacetylase Binding Transcription Coactivator Binding Cellular Response To Nicotine Positive Regulation Of MiRNA Transcription Nucleic Acid Metabolic Process Nucleobase-containing Compound Biosynthetic Process Transcription Repressor Complex Regulation Of Interleukin-12 Production Meiotic Sister Chromatid Cohesion Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Mechanical Stimulus Positive Regulation Of DNA-templated Transcription Initiation Regulation Of MiRNA Transcription Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Response To Interleukin-1 Regulation Of DNA-templated Transcription Initiation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific RNA Metabolic Process Actinin Binding Negative Regulation Of Signal Transduction Negative Regulation Of RNA Metabolic Process Cellular Response To Angiotensin Cellular Response To Interleukin-6 Protein Phosphatase Type 2A Complex Cytosol Transcription Regulator Complex Cytoplasm Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Chromatin Binding Transcription Cis-regulatory Region Binding	Positive Regulation Of Interleukin-1 Production RAGE Receptor Binding Protein Serine/threonine Phosphatase Activity Protein Localization To Microtubule Response To Lead Ion Regulation Of Interleukin-1 Production Protein Homodimerization Activity Phosphoprotein Phosphatase Activity Regulation Of Intracellular Signal Transduction Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Protein Kinase C Signaling Protein Localization To Cytoskeleton Phosphoprotein Binding RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Positive Regulation Of Interleukin-1 Beta Production Regulation Of Carbohydrate Catabolic Process Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of ATP Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Axo-dendritic Transport Regulation Of Signal Transduction Regulation Of Purine Nucleotide Metabolic Process Endosome To Plasma Membrane Transport Vesicle Regulation Of Supramolecular Fiber Organization Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Extracellular Exosome Regulation Of Interleukin-1 Beta Production Protein Kinase C Inhibitor Activity Regulation Of Canonical NF-kappaB Signal Transduction Cytoskeleton Protein Dephosphorylation RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Glycogen Phosphorylase Activity Regulation Of Microtubule Polymerization Or Depolymerization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway