UBE2W and UFM1

Number of citations: 61 (PubMedID 19690564)
Data Source: BioGRID (two hybrid)

		UBE2W	UFM1
Name		ubiquitin conjugating enzyme E2 W	ubiquitin fold modifier 1
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nucleus Cytoplasm Endoplasmic Reticulum
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity	Protein Binding
	Biological Process	Protein Polyubiquitination DNA Repair Protein Monoubiquitination Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins DNA Damage Response Protein Ubiquitination Cellular Response To Nutrient Levels TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Cellular Response To Misfolded Protein Antiviral Innate Immune Response Negative Regulation Of TORC1 Signaling	Brain Development Regulation Of Intracellular Estrogen Receptor Signaling Pathway Response To Endoplasmic Reticulum Stress Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of Apoptotic Process Reticulophagy Protein Ufmylation Protein K69-linked Ufmylation
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	None
GWAS		Cervical high-risk human papilloma virus infection ( 33225922 ) Malaria ( 31844061 ) Manganese levels ( 26025379 ) Urate levels in obese individuals ( 25811787 )	Aggressiveness in attention deficit hyperactivity disorder ( 27021288 ) Body mass index and diastolic blood pressure (bivariate analysis) ( 33539483 ) Low vWF levels ( 26486471 ) Schizophrenia ( 30285260 33169155 )
Interacting Genes		81 interacting genes: AKR1C3 AMFR ARK2C ATXN3 BARD1 BFAR BIRC2 BIRC8 BRCA1 CADPS2 CBL CHFR CNOT4 DNMT3B DTX3 DTX3L DZIP3 EED FANCL LRSAM1 MAP3K1 MAPT MARCHF3 MARCHF5 MGRN1 MIB1 MID1 MKRN1 MKRN3 MUL1 PJA2 POLR2C PSTPIP1 RFWD3 RMND5B RNF10 RNF103 RNF111 RNF114 RNF123 RNF125 RNF138 RNF14 RNF150 RNF152 RNF166 RNF167 RNF183 RNF185 RNF2 RNF26 RNF31 RNF4 RNF5 RNF8 ROPN1 SNCA STUB1 TOPORS TRIM17 TRIM2 TRIM21 TRIM23 TRIM27 TRIM3 TRIM31 TRIM35 TRIM39 TRIM5 TRIM59 TRIM7 TRIM8 UBA1 UBOX5 UFM1 UHRF2 USHBP1 XIAP ZNRF1 ZNRF2 ZNRF4	16 interacting genes: ARHGDIA ARHGDIB DIABLO GSK3B INCA1 KCTD21 RPS6KA6 SAYSD1 TSC22D2 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2W
Entrez ID		55284	51569
HPRD ID		07724	15644
Ensembl ID		ENSG00000104343	ENSG00000120686
Uniprot IDs		Q96B02 Q96FI0 X6REH9	P61960
PDB IDs		2A7L 2MT6 8A58	1WXS 5HKH 5IA7 5IA8 5IAA 5L95 6H77 7W3N 8BZR 8OHD 8OJ0 8OJ5 8QFC
GO Terms Enriched among Interactors		Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein Modification Process Transferase Activity Zinc Ion Binding Protein Metabolic Process Metal Ion Binding Macromolecule Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Protein Autoubiquitination Proteolysis Catabolic Process Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein Catabolic Process Response To Stress Proteasomal Protein Catabolic Process Cellular Response To Stress Protein K6-linked Ubiquitination Ubiquitin Ligase Complex Regulation Of Intracellular Signal Transduction Protein Monoubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Signal Transduction Cytoplasm Canonical NF-kappaB Signal Transduction Suppression Of Viral Release By Host Positive Regulation Of Catabolic Process Innate Immune Response Immune System Process DNA Damage Response Positive Regulation Of Autophagy Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Response To Other Organism Regulation Of Autophagy Regulation Of Signaling Regulation Of Cell Communication Regulation Of Defense Response Defense Response To Symbiont Endoplasmic Reticulum Mannose Trimming Intracellular Signal Transduction Defense Response To Other Organism Response To External Biotic Stimulus	Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Proteolysis Involved In Protein Catabolic Process Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Ubiquitination Protein K11-linked Ubiquitination Protein Modification By Small Protein Conjugation Protein Monoubiquitination Proteolysis Post-translational Protein Modification ATP Binding TOR Signaling Macromolecule Catabolic Process Rho GDP-dissociation Inhibitor Activity Protein Modification Process Transferase Activity Nucleotide Binding TORC1 Signaling Protein Metabolic Process Negative Regulation Of TOR Signaling Catabolic Process Protein K6-linked Ubiquitination Regulation Of TOR Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Regulation Of Signal Transduction Intracellular Signal Transduction Proteasomal Protein Catabolic Process Regulation Of Microtubule Anchoring At Centrosome Negative Regulation Of Signal Transduction Rho Protein Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Superior Temporal Gyrus Development Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Signaling Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity Negative Regulation Of Cell Communication Negative Regulation Of TORC1 Signaling Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Embryonic Development Protein Autoubiquitination Protein Catabolic Process Protein K63-linked Ubiquitination Cellular Response To Redox State Negative Regulation Of Mesoderm Development