PRMT6 and GTPBP2

Number of citations: 0 (PubMedID 23455924)
Data Source: BioGRID (affinity chromatography technology, two hybrid)

		PRMT6	GTPBP2
Name		protein arginine methyltransferase 6	GTP binding protein 2
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus	Extracellular Region Platelet Alpha Granule Lumen
	Molecular Function	Chromatin Binding Protein Binding Methyltransferase Activity Histone Arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Transferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Histone Binding Histone H4R3 Methyltransferase Activity Histone H3R2 Methyltransferase Activity Histone H2AR3 Methyltransferase Activity Histone H3 Methyltransferase Activity	Nucleotide Binding Translation Elongation Factor Activity GTPase Activity Protein Binding GTP Binding Identical Protein Binding Alpha-aminoacyl-tRNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Base-excision Repair Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription DNA Damage Response Regulation Of Mitochondrion Organization Methylation Cellular Response To Stress Regulation Of Megakaryocyte Differentiation Negative Regulation Of DNA-templated Transcription Cellular Senescence Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process	Translational Elongation Nuclear-transcribed MRNA Catabolic Process, No-go Decay Rescue Of Stalled Ribosome
Pathways		RMTs methylate histone arginines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Platelet degranulation
GWAS		Adult body size ( 32376654 ) Blood pressure measurement (low sodium intervention) ( 24165912 ) Intelligence ( 22449649 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Low density lipoprotein cholesterol levels ( 32154731 ) Non-obstructive azoospermia ( 22197933 ) Obesity (early onset extreme) ( 23563609 ) Refractive error ( 32231278 ) Response to SSRI in MDD or openness ( 29559929 ) Restless legs syndrome ( 29029846 ) Sex hormone-binding globulin levels ( 22829776 ) Waist circumference ( 28552196 ) Weight ( 28552196 )	Adult body size ( 32376654 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )
Interacting Genes		90 interacting genes: AK8 AP1G2 ASB3 AUNIP BCAT1 BLZF1 BMP3 C8orf74 CDCA4 CETN2 DCAF16 DNAJA3 DNALI1 DXO FBL FIP1L1 FKBP7 FYCO1 FYN GBE1 GPS2 GRHL3 GSTCD GTPBP2 H2AC18 H2BC21 H3-5 H3C14 H3C15 H4C16 H4C6 HESX1 HMGA1 HMGA2 HNRNPH2 HOXA1 HOXA5 HOXC4 ID2 KIAA0408 KIF9 KLHL20 LDHAL6B LENG8 LINC02875 LOXL4 MALT1 MED28 METTL27 MLC1 MNDA MTF2 NEFL NOSTRIN NR1D2 OAS1 OPA3 PABPC1 PCGF5 PELO PEX7 PSMD11 PYCR3 PYGO1 RAC1 RAD17 RASSF2 SERGEF SLU7 SMAD9 SMARCD1 SNF8 SPATA22 SPIN1 SPSB1 SRGAP3 SSX2IP STARD10 SUV39H1 TDO2 TEX35 THEMIS TMED5 TRIB2 TSC1 UBXN10 WDFY3 ZNF436 ZNF557 ZSCAN9	12 interacting genes: CLK2 GPN3 KDM1A NXF1 PICK1 PLEKHF2 PRMT5 PRMT6 PSMB1 SNRNP70 SUV39H1 TXN2
Entrez ID		55170	54676
HPRD ID		10505	08465
Ensembl ID		ENSG00000198890	ENSG00000172432
Uniprot IDs		Q96LA8	A8K2K2 Q9BX10
PDB IDs		4HC4 4QPP 4QQK 4Y2H 4Y30 5E8R 5EGS 5HZM 5WCF 6P7I 6W6D 6WAD 7NR4	Not available
GO Terms Enriched among Interactors		Nucleus Structural Constituent Of Chromatin Protein Binding Nucleosome Nucleoplasm Chromatin Organization Nucleosome Organization Chromatin Remodeling Chromosome Senescence-associated Heterochromatin Focus	Histone H3 Methyltransferase Activity Histone Methyltransferase Activity Histone Arginine N-methyltransferase Activity Histone H4R3 Methyltransferase Activity Protein-arginine N-methyltransferase Activity Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of MRNA Splicing, Via Spliceosome Histone Methyltransferase Complex Methyltransferase Activity Regulation Of RNA Splicing Chromatin Binding Methylation Positive Regulation Of RNA Splicing Nucleoplasm Cellular Response To Glucose Starvation Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Histone H2AR3 Methyltransferase Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Epigenetic Regulation Of Gene Expression Negative Regulation Of Protein Refolding Chromatin Remodeling P53 Binding Peptidyl-arginine N-methylation Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Histone H3R2 Methyltransferase Activity Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Phosphorylation Negative Regulation Of Metabolic Process Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Chaperone-mediated Autophagy ENoSc Complex Protein-arginine Omega-N Symmetric Methyltransferase Activity Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Nuclear Speck Phosphorylation Macromolecule Metabolic Process Release From Viral Latency Negative Regulation Of Catabolic Process Negative Regulation Of Protein Catabolic Process Secretory Granule Lumen Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Protein Folding Histone H3K9 Trimethyltransferase Activity RDNA Heterochromatin Chromatin Organization Membrane Curvature Sensor Activity Positive Regulation Of Dopamine Receptor Signaling Pathway Peptidyl-arginine Methylation