SHQ1 and GMCL2

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		SHQ1	GMCL2
Name		SHQ1, H/ACA ribonucleoprotein assembly factor	germ cell-less 2, spermatogenesis associated
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cajal Body	Nucleus Nuclear Matrix
	Molecular Function	Protein Binding Unfolded Protein Binding	Protein Binding Cullin Family Protein Binding
	Biological Process	Box H/ACA SnoRNP Assembly Protein-RNA Complex Assembly Regulation Of Androgen Receptor Signaling Pathway Telomerase RNA Localization To Cajal Body Positive Regulation Of TORC1 Signaling	Germ Cell Development Spermatogenesis Protein Ubiquitination Cell Differentiation
Pathways		Telomere Extension By Telomerase	None
GWAS		Metabolite levels ( 23823483 ) Type 2 diabetes ( 30297969 )	No GWAS studies recorded
Interacting Genes		3 interacting genes: AKT1 GMCL1 GMCL2	22 interacting genes: ADAMTSL4 BCL11A BHLHE40 CHCHD3 DVL2 FBXO7 GAGE12B GAGE12I GAGE2E GAGE5 HNRNPM IKZF1 KAT5 LIMS3 LZTS2 MEOX2 SHQ1 TRAF1 TRIM23 UBE2I USHBP1 XAGE2
Entrez ID		55164	64396
HPRD ID		07682	17044
Ensembl ID		ENSG00000144736	ENSG00000244234
Uniprot IDs		Q6PI26	Q8NEA9
PDB IDs		2MNW 4PBD 4PCK	Not available
GO Terms Enriched among Interactors		Germ Cell Development Developmental Process Involved In Reproduction Cell Development Regulation Of TRNA Methylation Nuclear Matrix Response To Rapamycin Positive Regulation Of Protein Localization To Endoplasmic Reticulum Nitric-oxide Synthase Regulator Activity Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of SREBP Signaling Pathway Response To Insulin-like Growth Factor Stimulus Negative Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of TORC2 Signaling Reproductive Process TRNA Stabilization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Potassium Channel Activator Activity Mammalian Oogenesis Stage RNA (guanine-N7)-methylation Negative Regulation Of Fatty Acid Transport Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Cellular Response To Peptide Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Maintenance Of Protein Location In Mitochondrion TRNA (guanine-N7)-methylation Activation-induced Cell Death Of T Cells Regulation Of Long-chain Fatty Acid Import Into Cell TORC2 Complex Binding Cellular Response To Rapamycin Peripheral Nervous System Myelin Maintenance Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Deoxyribonuclease Activity Negative Regulation Of Protein Localization To Lysosome Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Endodeoxyribonuclease Activity SREBP-SCAP Complex Retention In Endoplasmic Reticulum Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Maternal Placenta Development Regulation Of SREBP Signaling Pathway Maintenance Of Protein Localization In Endoplasmic Reticulum Vascular Endothelial Cell Response To Fluid Shear Stress Interleukin-18-mediated Signaling Pathway Sphingosine-1-phosphate Receptor Signaling Pathway Sphingolipid Mediated Signaling Pathway Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Behavioral Response To Pain	None