MSTO1 and NR1H3

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		MSTO1	NR1H3
Name		misato mitochondrial distribution and morphology regulator 1	nuclear receptor subfamily 1 group H member 3
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Receptor Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Cholesterol Binding Chromatin DNA Binding Sterol Response Element Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Mitochondrion Organization Positive Regulation Of Mitochondrial Fusion Mitochondrion Distribution	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Lipid Metabolic Process Hormone-mediated Signaling Pathway Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Efflux Regulation Of Lipid Storage Negative Regulation Of Cholesterol Storage Cell Differentiation Intracellular Receptor Signaling Pathway Negative Regulation Of Lipid Transport Positive Regulation Of Cholesterol Transport Response To Progesterone Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Phosphatidylcholine Acyl-chain Remodeling Cholesterol Homeostasis Regulation Of Circadian Rhythm MRNA Transcription By RNA Polymerase II Negative Regulation Of Macrophage Activation Apoptotic Cell Clearance Positive Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Proteolysis Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Lipid Biosynthetic Process Negative Regulation Of Pinocytosis Negative Regulation Of Inflammatory Response Lipid Homeostasis Sterol Homeostasis Negative Regulation Of Type II Interferon-mediated Signaling Pathway Triglyceride Homeostasis Cellular Response To Lipopolysaccharide Negative Regulation Of Pancreatic Juice Secretion Negative Regulation Of Secretion Of Lysosomal Enzymes Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Response To Endoplasmic Reticulum Stress
Pathways		None	PPARA activates gene expression VLDLR internalisation and degradation NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis
Drugs		None	TO-901317 N-(TERT-BUTYL)-3,5-DIMETHYL-N'-[(5-METHYL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)CARBONYL]BENZOHYDRAZIDE 1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONE (2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID Diacerein Rhein
GWAS		Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (min-P) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Crohn's disease ( 28067908 ) Inflammatory bowel disease ( 23128233 28067908 ) Serum cancer antigen 15.3 levels ( 31666285 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Urinary albumin-to-creatinine ratio ( 31630189 )	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Blood glucose levels ( 31928498 ) Creatinine levels ( 29403010 ) Feeling miserable ( 29500382 ) Glycated hemoglobin levels ( 34059833 ) HDL cholesterol ( 20686565 19060910 ) Hypertension ( 31879980 ) Intraocular pressure ( 29785010 ) Lymphocyte percentage of white cells ( 27863252 ) Metabolic syndrome ( 22399527 ) Monocyte percentage of white cells ( 27863252 ) Mood instability ( 31168069 ) Neurociticism ( 29500382 ) Neuroticism ( 29255261 ) Refractive error ( 32231278 ) Systolic blood pressure ( 31928498 ) Triglyceride levels ( 32154731 ) Triglycerides ( 30275531 )
Interacting Genes		7 interacting genes: CASP9 EP300 HDDC3 NR1H3 OGT RUNX1 UBE3A	35 interacting genes: ACTN1 APP BAG3 CEP350 EDF1 FOXO3 GPANK1 ING3 KAT2B KDM1A LZTR1 MDFI MSTO1 NCOA1 NCOA3 NCOA6 NCOR1 NR0B2 NR3C1 NRIP1 PPARA PPARD PPARG PSMC5 RARA RXRA RXRB RXRG SIRT1 SS18L1 SUV39H1 SYT1 TMEM161A UBE2I ZXDC
Entrez ID		55154	10062
HPRD ID		16904	07211
Ensembl ID		ENSG00000125459	ENSG00000025434
Uniprot IDs		A0A3B3IUD2 Q9BUK6	B4DXU5 B5MBY7 F1D8N1 Q13133
PDB IDs		Not available	1UHL 3IPQ 3IPS 3IPU 5AVI 5AVL 5HJS
GO Terms Enriched among Interactors		Response To Hormone Positive Regulation Of TORC1 Signaling Chromatin DNA Binding Positive Regulation Of TOR Signaling Regulation Of TORC1 Signaling Regulation Of Proteolysis Regulation Of TOR Signaling Platelet Formation Histone Acetyltransferase Complex Hemopoiesis Response To Ketone Response To Steroid Hormone Positive Regulation Of Transcription By RNA Polymerase II Response To Progesterone Protein Maturation Caspase Complex Cellular Response To Oxygen-containing Compound Myeloid Cell Differentiation Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Transcription Coactivator Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of DNA-templated Transcription Regulation Of Protein Metabolic Process Peptidyl-lysine Propionylation Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Regulation Of Small Molecule Metabolic Process Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Regulation Of Protein Localization Cellular Response To Nutrient Levels Histone Crotonyltransferase Activity Regulation Of Gluconeogenesis Rhythmic Process TORC1 Signaling Sperm Entry Positive Regulation Of Golgi Lumen Acidification Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Secretion Of Lysosomal Enzymes Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase Activity Intracellular Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Developmental Growth Positive Regulation Of Alpha-beta T Cell Activation	Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nuclear Receptor-mediated Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Nuclear Receptor Activity Hormone-mediated Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Transcription Positive Regulation Of Biosynthetic Process Chromatin Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Metabolic Process Transcription Coactivator Activity Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Regulation Of MiRNA Metabolic Process Negative Regulation Of MiRNA Transcription Intracellular Receptor Signaling Pathway Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Rhythmic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Nuclear Retinoid X Receptor Binding Nucleoplasm RNA Polymerase II Transcription Regulator Complex Regulation Of Macromolecule Biosynthetic Process Nuclear Receptor Binding Retinoic Acid-responsive Element Binding Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Nuclear Steroid Receptor Activity Regulation Of Programmed Cell Death Peroxisome Proliferator Activated Receptor Signaling Pathway Cellular Response To Oxygen-containing Compound Regulation Of Lipid Metabolic Process Nucleus MRNA Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process