AVP and AVPR1B

Number of citations: 0 (PubMedID 7929452)
Data Source: HPRD (in vivo)

		AVP	AVPR1B
Name		arginine vasopressin	arginine vasopressin receptor 1B
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Secretory Granule Dendrite Clathrin-coated Endocytic Vesicle Membrane Neuronal Dense Core Vesicle	Endosome Golgi Apparatus Plasma Membrane Membrane
	Molecular Function	Protein Kinase Activity Signaling Receptor Binding Hormone Activity Neuropeptide Hormone Activity Neurohypophyseal Hormone Activity Protein Binding V1A Vasopressin Receptor Binding V1B Vasopressin Receptor Binding	G Protein-coupled Receptor Activity Vasopressin Receptor Activity Protein Kinase C Binding G Protein-coupled Peptide Receptor Activity
	Biological Process	Maternal Aggressive Behavior Positive Regulation Of Systemic Arterial Blood Pressure Generation Of Precursor Metabolites And Energy Water Transport Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Negative Regulation Of Female Receptivity Grooming Behavior Locomotory Behavior Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Salt Stress Positive Regulation Of Gene Expression Positive Regulation Of Glutamate Secretion Positive Regulation Of Cell Growth Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Cellular PH Reduction Multicellular Organismal Response To Stress Response To Testosterone Response To Nicotine Social Behavior Intracellular Signal Transduction Vasoconstriction Maternal Behavior Negative Regulation Of Apoptotic Process Response To Ethanol Positive Regulation Of Vasoconstriction Symbiont Entry Into Host Cell Multicellular Organismal-level Water Homeostasis Response To Electrical Stimulus Negative Regulation Of Transmission Of Nerve Impulse Renal Water Absorption Blood Vessel Diameter Maintenance Response To Peptide Response To 2,3,7,8-tetrachlorodibenzodioxine Response To Nerve Growth Factor	Regulation Of Systemic Arterial Blood Pressure By Vasopressin Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Blood Pressure Cellular Response To Hormone Stimulus Regulation Of Cell Population Proliferation Positive Regulation Of MAPK Cascade Positive Regulation Of Vasoconstriction Symbiont Entry Into Host Cell Positive Regulation Of Inositol Phosphate Biosynthetic Process Positive Regulation Of Arachidonate Secretion Transport Across Blood-brain Barrier
Pathways		BMAL1:CLOCK,NPAS2 activates circadian expression Vasopressin-like receptors G alpha (q) signalling events G alpha (s) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) Organic anion transport by SLCO transporters Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)	Vasopressin-like receptors G alpha (q) signalling events Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)
Drugs		None	Desmopressin Vasopressin Terlipressin PH-284 SR 121463 Atosiban Lypressin
Diseases		Neurohypophyseal diabetes insipidus (NPDI); Central Diabetes Insipidus	None
GWAS		No GWAS studies recorded	No GWAS studies recorded
Interacting Genes		9 interacting genes: AVPR1A AVPR1B AVPR2 CRYAB DLX2 KMT2A OXTR PRKAB2 TXNDC17	2 interacting genes: AVP GRK5
Entrez ID		551	553
HPRD ID		01891	02600
Ensembl ID		ENSG00000101200	ENSG00000198049
Uniprot IDs		P01185 X5DQP6	P47901
PDB IDs		7BB6 7BB7 7DW9 7KH0 7R0C	Not available
GO Terms Enriched among Interactors		Regulation Of Systemic Arterial Blood Pressure By Vasopressin Vasopressin Receptor Activity Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Vasoconstriction Regulation Of Systemic Arterial Blood Pressure Regulation Of Vasoconstriction Positive Regulation Of Blood Pressure Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of Blood Pressure Regulation Of Blood Circulation Vascular Process In Circulatory System Circulatory System Process Cellular Response To Hormone Stimulus G Protein-coupled Receptor Activity System Process Positive Regulation Of Systemic Arterial Blood Pressure Telencephalon Development Signal Transduction Regulation Of System Process G Protein-coupled Peptide Receptor Activity Response To Hormone Protein Kinase C Binding Positive Regulation Of Metabolic Process G Protein-coupled Receptor Signaling Pathway Renal Water Retention Oxytocin Receptor Activity Endocytic Vesicle Regulation Of Biological Quality Transport Across Blood-brain Barrier Positive Regulation Of Multicellular Organismal Process V1A Vasopressin Receptor Binding Cerebral Cortex GABAergic Interneuron Fate Commitment Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Protein-cysteine Methyltransferase Activity Positive Regulation Of Cold-induced Thermogenesis Regulation Of Multicellular Organismal Process Regulation Of Metabolic Process Cellular Response To Water Deprivation Response To Water Deprivation Sperm Ejaculation Negative Regulation Of Female Receptivity Maternal Aggressive Behavior Subpallium Development Positive Regulation Of Amacrine Cell Differentiation Cerebral Cortex GABAergic Interneuron Differentiation Protein-disulfide Reductase [NAD(P)H] Activity Positive Regulation Of Cellular PH Reduction Positive Regulation Of Arachidonate Secretion Negative Regulation Of Urine Volume	V1A Vasopressin Receptor Binding Regulation Of Female Receptivity Renal Water Transport Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cellular PH Reduction Renal Water Absorption Negative Regulation Of Female Receptivity Female Mating Behavior Neurohypophyseal Hormone Activity Aggressive Behavior Protein Kinase Activity Negative Regulation Of Transmission Of Nerve Impulse Response To 2,3,7,8-tetrachlorodibenzodioxine V1B Vasopressin Receptor Binding Maternal Aggressive Behavior Tachykinin Receptor Signaling Pathway Beta-adrenergic Receptor Kinase Activity G Protein-coupled Receptor Kinase Activity Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Unsaturated Fatty Acid Biosynthetic Process Positive Regulation Of Glutamate Secretion Regulation Of Prostaglandin Biosynthetic Process Maternal Behavior Grooming Behavior Parental Behavior Positive Regulation Of Systemic Arterial Blood Pressure G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Nervous System Process Regulation Of Transmission Of Nerve Impulse Regulation Of Glutamate Secretion Response To Salt Stress Mating Behavior Neuronal Dense Core Vesicle Negative Regulation Of Apoptotic Process Positive Regulation Of Amino Acid Transport Negative Regulation Of Programmed Cell Death Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Cell Population Proliferation Water Transport Multicellular Organismal-level Water Homeostasis Positive Regulation Of Vasoconstriction Neuropeptide Hormone Activity Positive Regulation Of Blood Pressure Vasoconstriction Reproductive Behavior Fluid Transport Response To Electrical Stimulus Positive Regulation Of Fatty Acid Metabolic Process Response To Testosterone Renal Absorption