PPP1CA and KANK1

Number of citations: 54 (PubMedID 15231748)
Data Source: HPRD (two hybrid)

		PPP1CA	KANK1
Name		protein phosphatase 1 catalytic subunit alpha	KN motif and ankyrin repeat domains 1
Structure
GO Annotations	Cellular Component	Protein Phosphatase Type 1 Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Adherens Junction Glycogen Granule Neuronal Cell Body Dendritic Spine Perikaryon Extracellular Exosome PTW/PP1 Phosphatase Complex Presynapse Postsynapse Glutamatergic Synapse	Nucleus Cytoplasm Cytoskeleton Plasma Membrane Cell Cortex Membrane Ruffle Membrane Cell Projection
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Iron Ion Binding Protein Binding Protein Phosphatase 1 Binding Hydrolase Activity Phosphatase Activity Ribonucleoprotein Complex Binding Protein-containing Complex Binding Metal Ion Binding Transition Metal Ion Binding Cadherin Binding Involved In Cell-cell Adhesion RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity	Protein Binding Beta-catenin Binding Protein-macromolecule Adaptor Activity
	Biological Process	Telomere Maintenance RNA Polymerase II Promoter Clearance Glycogen Metabolic Process Regulation Of Glycogen Biosynthetic Process Regulation Of Glycogen Catabolic Process Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Protein Dephosphorylation Response To Lead Ion Dephosphorylation Lung Development Circadian Regulation Of Gene Expression Positive Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Telomere Maintenance In Response To DNA Damage Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Glycogen Biosynthetic Process Branching Morphogenesis Of An Epithelial Tube Protein Stabilization Cell Division Regulation Of Canonical Wnt Signaling Pathway Double-strand Break Repair Via Alternative Nonhomologous End Joining Cell-cell Adhesion Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Cell Population Proliferation Negative Regulation Of Neuron Projection Development Actin Cytoskeleton Organization Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Migration Negative Regulation Of Actin Filament Polymerization Regulation Of Rho Protein Signal Transduction Negative Regulation Of Rho Protein Signal Transduction Cortical Microtubule Organization Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wound Healing Podocyte Cell Migration Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Ruffle Assembly Regulation Of Establishment Of Cell Polarity Negative Regulation Of Lamellipodium Morphogenesis
Pathways		Triglyceride catabolism DARPP-32 events Downregulation of TGF-beta receptor signaling Maturation of hRSV A proteins Phosphorylation and nuclear translocation of the CRY:PER:kinase complex	Estrogen-dependent gene expression Signaling by membrane-tethered fusions of PDGFRA or PDGFRB
Drugs		2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid	None
Diseases		None	Cerebral palsy
GWAS		Body fat distribution (arm fat ratio) ( 30664634 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Height ( 28552196 )	Bone mineral density (femoral neck) in inflammatory bowel disease ( 29603369 ) Eye morphology ( 29921221 ) Fasting blood glucose ( 33842983 ) Fasting plasma glucose ( 25187374 ) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269 ) Night sleep phenotypes ( 27126917 ) Post bronchodilator FEV1/FVC ratio ( 26634245 ) Proinsulin levels (early-phase conversion) ( 23263489 ) Serum bilirubin levels in metabolic syndrome ( 30621171 ) Systolic blood pressure ( 30224653 ) Uterine fibroids ( 30194396 )
Interacting Genes		173 interacting genes: AATK AHCTF1 AKAP1 AKAP11 AKAP9 AKT1 APAF1 ASPM AURKA BAD BAX BCL2 BCL2L1 BCL2L2 BRCA1 BTBD10 C1QA CAD CAV1 CCDC181 CDC5L CDCA2 CDH1 CEP126 CEP170 CEP192 CKB CLCN2 CLOCK CNP CNST CNTN1 CREB1 CRK CSNK1E CSNK2B CSRNP1 CSRNP2 CUL1 CXXC1 DCTN1 DCX DEAF1 DELEC1 DYNLT4 EED EIF2AK2 ESR1 FRMPD4 FXYD1 GLIPR1L2 GPKOW H2AX H3-3A H3C1 HEYL HSPA4 IBTK ID2 ITGB8 JPH3 KANK1 KCNQ1 KCTD20 KIF13A KIF18A KNL1 LMTK2 LPIN2 MAFG MAL2 MAP4K4 MAPK1 MAPK3 MAPT MECOM MIIP MKI67 MPHOSPH10 MST1R MYO16 NCAM1 NDP NEDD8 NEK2 NOC2L NOM1 NONO NOP53 PAK1 PBK PCDH7 PCNA PHACTR1 PHACTR3 PHACTR4 PHB2 PHC1 PIAS1 PIAS3 PLCL2 POLR2A PPP1R10 PPP1R11 PPP1R13B PPP1R13L PPP1R15A PPP1R15B PPP1R16A PPP1R18 PPP1R1B PPP1R2 PPP1R26 PPP1R27 PPP1R2B PPP1R2C PPP1R37 PPP1R3B PPP1R3C PPP1R3D PPP1R3E PPP1R3G PPP1R8 PPP1R9A PPP1R9B PPP2CA PPP2R5C PPP2R5E PREX1 PRKCB PRKCD PRR16 PTEN PTPN7 PYGM RANBP9 RB1 RORC RPRD2 RRP1B SAXO4 SEH1L SFI1 SFRP1 SH3RF2 SKP1 SLC45A1 SORL1 SPRED1 STAM STAU1 SYTL2 TOE1 TOR1AIP1 TOX4 TP53 TP53BP2 TPRN TRIM21 TSC2 TUSC3 UBC UBE2Z UBR5 ULK1 VDR WBP11 WDR82 YLPM1 ZBTB11 ZFYVE16 ZFYVE9 ZNF827	9 interacting genes: AKT1 BAIAP2 PPP1CA YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		5499	23189
HPRD ID		15942	09651
Ensembl ID		ENSG00000172531	ENSG00000107104
Uniprot IDs		A0A140VJS9 P62136	A0A8I5KRP2 A0A8I5KT40 A0A8I5KZ49 Q14678
PDB IDs		3E7A 3E7B 3EGG 3EGH 3HVQ 3N5U 3V4Y 4G9J 4MOV 4MOY 4MP0 4XPN 5IOH 6ALZ 6CZO 6DCX 6DNO 6G0I 6G0J 6GHM 6OBN 6OBP 6OBQ 6OBR 6OBS 6OBU 6ZEE 6ZEF 6ZEG 6ZEH 6ZEI 6ZEJ 6ZK6 7QFB 7QM2 7T0Y 7TVF 7TXH 7UPI 8DWK 8DWL 8SW5 8SW6 8U5G	5YBJ 5YBU 8AS9 8IVZ 8IW0
GO Terms Enriched among Interactors		Protein Phosphatase 1 Binding Protein Phosphatase Inhibitor Activity Phosphatase Binding Intracellular Signal Transduction Protein Phosphatase Regulator Activity Protein Phosphatase Type 1 Complex Negative Regulation Of Intracellular Signal Transduction Apoptotic Process Programmed Cell Death Cell Death Regulation Of Cell Cycle Enzyme Binding Regulation Of Intracellular Signal Transduction Nucleoplasm Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Intrinsic Apoptotic Signaling Pathway Nucleus Glycogen Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Glycogen Binding Regulation Of Cell Cycle Process Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Cytoplasm Positive Regulation Of Metabolic Process Polysaccharide Metabolic Process Energy Reserve Metabolic Process Cell Population Proliferation Release Of Cytochrome C From Mitochondria Chromosome Response To Radiation Apoptotic Signaling Pathway Negative Regulation Of Metabolic Process Regulation Of Protein-containing Complex Assembly Negative Regulation Of Programmed Cell Death Response To Starvation Regulation Of Glycogen Biosynthetic Process Protein Localization To Organelle Negative Regulation Of Apoptotic Process Regulation Of Cell Cycle Phase Transition Negative Regulation Of Protein Metabolic Process Signal Transduction Cellular Response To Oxygen-containing Compound Response To Light Stimulus Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Bcl-2 Family Protein Complex	Protein Domain Specific Binding Phosphoserine Residue Binding Protein Sequestering Activity Protein Targeting Intracellular Protein Localization Identical Protein Binding Extracellular Exosome Establishment Of Protein Localization Transmembrane Transporter Binding Focal Adhesion Substantia Nigra Development Glutamatergic Synapse TORC1 Signaling Presynapse Neural Nucleus Development Negative Regulation Of TORC1 Signaling Positive Regulation Of Toll-like Receptor Signaling Pathway TOR Signaling Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Melanosome Regulation Of Translational Initiation Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Transmembrane Transport Cytosol Insulin-like Growth Factor Receptor Binding Enzyme Binding Protein Localization To Endoplasmic Reticulum Positive Regulation Of Glycogen Biosynthetic Process Cadherin Binding Involved In Cell-cell Adhesion Regulation Of Monoatomic Ion Transport Regulation Of Protein Localization Negative Regulation Of Transport Regulation Of Membrane Potential Regulation Of Biological Quality Regulation Of TOR Signaling Negative Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Protein Localization To Nucleus Protein K6-linked Ubiquitination Intracellular Signal Transduction Vesicle Negative Regulation Of Immune System Process Regulation Of Glycogen Biosynthetic Process Cellular Response To Starvation Signal Transduction 14-3-3 Protein Binding Regulation Of Synaptic Plasticity Regulation Of Signal Transduction Negative Regulation Of Protein Localization