INTS11 and DSE

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		INTS11	DSE
Name		integrator complex subunit 11	dermatan sulfate epimerase
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Integrator Complex Blood Microparticle INTAC Complex	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle
	Molecular Function	RNA Endonuclease Activity Protein Binding Hydrolase Activity Metal Ion Binding	Isomerase Activity Metal Ion Binding Chondroitin-glucuronate 5-epimerase Activity
	Biological Process	Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II SnRNA Processing Regulation Of Transcription Elongation By RNA Polymerase II SnRNA 3'-end Processing RNA Polymerase II Transcription Initiation Surveillance	Heparan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Biosynthetic Process Chondroitin Sulfate Proteoglycan Metabolic Process Dermatan Sulfate Proteoglycan Metabolic Process
Pathways		RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes	DS-GAG biosynthesis
GWAS		No GWAS studies recorded	Fast beta electroencephalogram ( 28040410 ) Height ( 28552196 ) Heschl's gyrus morphology ( 25130324 ) Hip circumference adjusted for BMI ( 34021172 ) Mean platelet volume ( 32888494 ) Platelet count ( 32888494 ) Refractive error ( 32231278 ) Systemic lupus erythematosus ( 33272962 33536424 )
Interacting Genes		39 interacting genes: ANXA7 C1orf94 CCDC120 CREB5 CSNK2B DSE FAM222B GPS2 HSF4 INTS9 KRTAP15-1 KRTAP26-1 LASP1 LENG8 MDFI NSMF OTX1 OXER1 PKN1 PLK1 PLSCR1 PLSCR4 PROP1 PRR35 SNRPC SPAG8 SPIC TBX6 TCF7L2 TFG TK1 TLX3 TRIP13 USP2 VAC14 VENTX YPEL3 ZC3H10 ZIC1	2 interacting genes: ACSL4 INTS11
Entrez ID		54973	29940
HPRD ID		13377	05807
Ensembl ID		ENSG00000127054	ENSG00000111817
Uniprot IDs		A0A087WYI0 Q5TA45	A0A2R8YE23 A0A2U3TZJ0 B3KY37 B7Z1T3 B7Z765 Q9UL01
PDB IDs		5V8W 7BFP 7BFQ 7CUN 7PKS 7YCX 8R22 8R23 8R2D 8RBX 8RBZ 8RC4 8UIB 8YJB	6HZN
GO Terms Enriched among Interactors		Nucleus Regulation Of Transcription By RNA Polymerase II Chromatin Sequence-specific Double-stranded DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription CD4 Receptor Binding Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Chromosome Separation	Negative Regulation Of Prostaglandin Secretion Long-chain Fatty-acyl-CoA Biosynthetic Process Negative Regulation Of Icosanoid Secretion Very Long-chain Fatty Acid-CoA Ligase Activity Long-chain Fatty Acid-CoA Ligase Activity Embryonic Process Involved In Female Pregnancy Alpha-linolenic Acid Metabolic Process Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Arachidonate-CoA Ligase Activity Nucleobase-containing Compound Biosynthetic Process Negative Regulation Of Fatty Acid Transport Palmitoyl-CoA Ligase Activity SnRNA 3'-end Processing Integrator Complex INTAC Complex RNA Polymerase II Transcription Initiation Surveillance Long-chain Fatty-acyl-CoA Metabolic Process Fatty-acyl-CoA Biosynthetic Process Long-chain Fatty Acid Biosynthetic Process Negative Regulation Of Lipid Transport Regulation Of Fatty Acid Transport Unsaturated Fatty Acid Biosynthetic Process SnRNA Processing Nuclear RNA Surveillance RNA Surveillance RNA Endonuclease Activity Transcription Elongation By RNA Polymerase II Fatty Acid Derivative Biosynthetic Process SnRNA Metabolic Process DNA-templated Transcription Elongation Peroxisomal Membrane Fatty Acid Derivative Metabolic Process Unsaturated Fatty Acid Metabolic Process Lipid Droplet Long-chain Fatty Acid Metabolic Process Acyl-CoA Metabolic Process Positive Regulation Of Insulin Secretion RNA 3'-end Processing Regulation Of Transcription Elongation By RNA Polymerase II Sulfur Compound Biosynthetic Process Regulation Of DNA-templated Transcription Elongation Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Fatty Acid Biosynthetic Process Ligase Activity Blood Microparticle Peroxisome Olefinic Compound Metabolic Process Regulation Of Lipid Transport