TMEM132A and MEGF10

Number of citations: 39 (PubMedID 12421765)
Data Source: HPRD (two hybrid)

		TMEM132A	MEGF10
Name		transmembrane protein 132A	multiple EGF like domains 10
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane Extracellular Exosome	Phagocytic Cup Plasma Membrane Membrane Cell Projection
	Molecular Function	Protein Homodimerization Activity	Complement Component C1q Complex Binding Scavenger Receptor Activity Notch Binding
	Biological Process	Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Catabolic Process Positive Regulation Of Wnt Protein Secretion	Phagocytosis Cell Adhesion Muscle Organ Development Skeletal Muscle Satellite Cell Activation Skeletal Muscle Satellite Cell Differentiation Skeletal Muscle Satellite Cell Proliferation Vesicle-mediated Transport Positive Regulation Of Cell-cell Adhesion Muscle Cell Proliferation Homotypic Cell-cell Adhesion Apoptotic Cell Clearance Engulfment Of Apoptotic Cell Recognition Of Apoptotic Cell Cell Development Myoblast Development Regulation Of Skeletal Muscle Tissue Development Regulation Of Muscle Cell Differentiation Myoblast Migration Muscle Cell Development Apoptotic Process Involved In Development Positive Regulation Of Myoblast Proliferation
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	None
GWAS		Blood protein levels ( 30072576 )	Alzheimer's disease (cognitive decline) ( 23535033 ) Appendicular lean mass ( 33097823 ) Bone mineral content ( 31790847 ) Chromosomal aberration frequency (chromosome type) in genotoxic compound exposure ( 31586183 ) Hearing loss in Charcot-Marie-Tooth disease 1A ( 30958311 ) Initial pursuit acceleration ( 29064472 ) Response to antipsychotic treatment in schizophrenia ( 29503163 )
Interacting Genes		4 interacting genes: GSK3B HSPA5 MEGF10 UBC	24 interacting genes: AARS2 ALMS1 AP2M1 ARHGAP32 BAHD1 CADPS2 CEP57 CUL7 DHX16 GRB10 GULP1 HDAC4 ITSN2 MCF2L2 RANBP10 SART3 SCAPER SHANK3 SHTN1 SNRNP200 TAOK2 TMEM132A VWA8 ZNFX1
Entrez ID		54972	84466
HPRD ID		11034	14384
Ensembl ID		ENSG00000006118	ENSG00000145794
Uniprot IDs		Q24JP5	Q96KG7
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		ER Overload Response Ubiquitin Protein Ligase Binding ER-nucleus Signaling Pathway Positive Regulation Of Post-translational Protein Modification Superior Temporal Gyrus Development Negative Regulation Of Protein-containing Complex Assembly Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Mesenchymal Stem Cell Differentiation Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Glycogen (starch) Synthase Activity Regulation Of Microtubule Anchoring At Centrosome Positive Regulation Of Protein Ubiquitination Translational Initiation Cerebellum Structural Organization Regulation Of Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Regulation Of Protein Ubiquitination Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Positive Regulation Of Protein Localization To Cilium Negative Regulation Of TORC2 Signaling Proteolysis Negative Regulation Of Dopaminergic Neuron Differentiation Macromolecule Catabolic Process Regulation Of Glycogen (starch) Synthase Activity Regulation Of Post-translational Protein Modification Regulation Of ATF6-mediated Unfolded Protein Response Negative Regulation Of IRE1-mediated Unfolded Protein Response Engulfment Of Apoptotic Cell Recognition Of Apoptotic Cell Skeletal Muscle Satellite Cell Proliferation Myoblast Development Skeletal Muscle Satellite Cell Activation Cellular Response To Interleukin-3 Positive Regulation Of Protein Localization To Centrosome Regulation Of Type B Pancreatic Cell Development Post-translational Protein Targeting To Membrane, Translocation Skeletal Muscle Satellite Cell Differentiation Complement Component C1q Complex Binding Beta-catenin Destruction Complex Negative Regulation Of Glycogen Biosynthetic Process Regulation Of Protein Localization To Cilium Regulation Of Dopaminergic Neuron Differentiation Regulation Of Protein Localization To Centrosome Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Protein Binding Regulation Of Mesenchymal Stem Cell Differentiation Positive Regulation Of Protein Modification Process Regulation Of Protein Folding Maintenance Of Protein Localization In Endoplasmic Reticulum PERK-mediated Unfolded Protein Response	Cytoplasm