PPL and OPRM1

Number of citations: 0 (PubMedID 12810704)
Data Source: HPRD (two hybrid, in vitro, in vivo)

		PPL	OPRM1
Name		periplakin	opioid receptor mu 1
Structure
GO Annotations	Cellular Component	Cornified Envelope Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Membrane Desmosome Extracellular Exosome Anchoring Junction	Cytoplasm Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Membrane Axon Dendrite Cell Projection Neuron Projection Perikaryon Synapse
	Molecular Function	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cadherin Binding	G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity Beta-endorphin Receptor Activity G Protein-coupled Opioid Receptor Activity Voltage-gated Calcium Channel Activity Protein Binding G Protein-coupled Peptide Receptor Activity G-protein Beta-subunit Binding Morphine Receptor Activity Neuropeptide Binding
	Biological Process	Response To Mechanical Stimulus Keratinization Wound Healing Intermediate Filament Cytoskeleton Organization	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Sensory Perception Negative Regulation Of Cell Population Proliferation Sensory Perception Of Pain G Protein-coupled Opioid Receptor Signaling Pathway Negative Regulation Of Nitric Oxide Biosynthetic Process Behavioral Response To Ethanol Positive Regulation Of Neurogenesis Negative Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Wnt Protein Secretion Positive Regulation Of ERK1 And ERK2 Cascade Calcium Ion Transmembrane Transport Cellular Response To Morphine Regulation Of Cellular Response To Stress Regulation Of NMDA Receptor Activity
Pathways		Formation of the cornified envelope Butyrophilin (BTN) family interactions	Opioid Signalling G-protein activation Peptide ligand-binding receptors G alpha (i) signalling events Interleukin-4 and Interleukin-13 signaling MECP2 regulates neuronal receptors and channels
Drugs		None	Tramadol Morphine Codeine Amitriptyline Hydromorphone Methadone Meperidine Oxycodone Levallorphan Dextromethorphan Butorphanol Dextropropoxyphene Pentazocine Naltrexone Sufentanil Alfentanil Fentanyl Loperamide Nalbuphine Levorphanol Remifentanil Ondansetron Anileridine Buprenorphine Hydrocodone Diphenoxylate Naloxone Oxymorphone Dezocine Ketamine Levacetylmethadol Aripiprazole Methadyl acetate 3-Methylthiofentanyl Dimethylthiambutene Diamorphine Ethylmorphine Etorphine Carfentanil Diprenorphine Dihydromorphine 3-Methylfentanyl V1003 Epicept NP-1 LI-301 Tapentadol Nalmefene Alvimopan Amisulpride Morphine glucuronide Ketobemidone Methylnaltrexone Naloxegol Cannabidiol Trimebutine Butyrfentanyl Pholcodine Eluxadoline Tianeptine Opium Pentoxyverine Naldemedine Samidorphan Metenkefalin Medical Cannabis Nabiximols Loxicodegol Oliceridine
GWAS		Adult body size ( 32376654 ) Appendicular lean mass ( 33097823 ) Cancer ( 29299148 ) Diastolic blood pressure ( 27841878 28135244 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Height ( 28552196 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Lung cancer (asbestos exposure interaction) ( 22637743 ) Metabolite levels (HVA/MHPG ratio) ( 23319000 ) Mitochondrial DNA copy number (white blood cells) ( 30704525 ) Systolic blood pressure ( 27841878 ) Waist circumference adjusted for body mass index ( 34021172 )	Adult body size ( 32376654 ) Body size at age 10 ( 32376654 ) Diastolic blood pressure ( 30224653 ) HDL cholesterol levels ( 32203549 ) Hypertension ( 21347282 ) Lipoprotein (a) levels ( 26377243 ) Menstruation quality of life impact (fever) ( 29855537 ) Methadone dose in opioid dependence ( 28115739 ) Nontraumatic osteonecrosis of the femoral head ( 32701715 ) Opioid use disorder ( 32492095 ) Type 2 diabetes (age of onset) ( 28060188 )
Interacting Genes		44 interacting genes: ACTR5 AHCYL1 AKT1 ALAS1 C6orf141 CASP6 CEP57L1 COL17A1 DES EVPL HECTD3 IKZF1 ITSN1 KAZN KCTD21 KNSTRN KRT25 KRT39 KRT8 MRPL28 OPRM1 PBX4 PICK1 PLEKHA7 POF1B PPHLN1 PTEN RAB3IP SKIL TRAF2 TRIM27 TSC22D4 UBC UPRT USP7 VIM WEE2-AS1 ZBTB26 ZNF165 ZNF213 ZNF263 ZNF474 ZSCAN1 ZSCAN16	78 interacting genes: ADAM33 ADD3 ALOX5AP ATP6V0C ATP6V0E1 C2CD2L CALM1 CCDC167 CD302 CLCN7 CLDN10 CLDN22 CLDN8 CLEC12B CLEC7A CNIH1 COPS5 CPLX1 CTXN3 CYB561 DNAJB4 DOK4 DOK5 DRD2 EHHADH EMP1 EMP3 FLNA GJA4 GNA15 GNAI1 GNAI2 GNAO1 GPRASP1 GRK3 GRM1 HS6ST1 IFITM3 KCNF1 LAT LPAR3 LRRC25 MAL MALL MAP1LC3A MAP1LC3C MFF NELFA NSG1 OPRD1 OPRL1 PLD2 PLD3 PMP22 PPL RPRM RTP4 SCGB1D1 SEC22A SERP2 SIAH1 SIAH2 SLC30A2 SLC38A7 SLC39A13 SLC41A1 SLC9A9 SMAGP TEX264 TM4SF4 TMBIM6 TMEM236 TRARG1 UBC VAPA WLS YIPF3 ZYX
Entrez ID		5493	4988
HPRD ID		04187	02484
Ensembl ID		ENSG00000118898	ENSG00000112038
Uniprot IDs		O60437	A0A6H0WF09 B8K2Q5 G8XRH4 G8XRH5 L0E130 P35372
PDB IDs		4Q28	8EF5 8EF6 8EFB 8EFL 8EFO 8EFQ 8F7Q 8F7R 8K9K 8K9L 9MQH 9MQI 9MQJ
GO Terms Enriched among Interactors		Intermediate Filament Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Identical Protein Binding Intermediate Filament Cytoskeleton Cellular Response To Rapamycin TORC1 Signaling Intermediate Filament Organization Regulation Of RNA Metabolic Process TOR Signaling Desmosome Response To Rapamycin Cell-cell Junction PML Body Regulation Of Nucleobase-containing Compound Metabolic Process Protein Domain Specific Binding Cellular Response To Ether	Membrane Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Plasma Membrane Bleb Assembly Cytoplasmic Vesicle Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Protein Binding Intracellular Monoatomic Cation Homeostasis Heterotrimeric G-protein Complex Intracellular Monoatomic Ion Homeostasis G Protein-coupled Receptor Binding Lysosomal Membrane Monoatomic Cation Homeostasis G Protein-coupled Serotonin Receptor Binding Monoatomic Ion Homeostasis Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Regulation Of Monoatomic Ion Transport Adenylate Cyclase Regulator Activity Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Monoatomic Cation Transport G Protein-coupled Dopamine Receptor Signaling Pathway Intracellular Chemical Homeostasis Transmembrane Transport Regulation Of Metal Ion Transport Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Monoatomic Ion Transport Endoplasmic Reticulum Membrane Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Bicellular Tight Junction Inorganic Ion Transmembrane Transport Phospholipase D Activity Cell-cell Signaling Membrane Raft Distribution G Protein-coupled Opioid Receptor Activity Anchoring Junction Monoatomic Ion Transmembrane Transport Chemical Synaptic Transmission Signaling Membrane Raft Localization Cellular Homeostasis Vesicle-mediated Transport Neuron-neuron Synaptic Transmission G Protein-coupled Opioid Receptor Signaling Pathway Proton-transporting V-type ATPase, V0 Domain Cell Communication