RASIP1 and RAP2A

Number of citations: 0 (PubMedID 15031288)
Data Source: HPRD (two hybrid)

		RASIP1	RAP2A
Name		Ras interacting protein 1	RAP2A, member of RAS oncogene family
Structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Golgi Stack Cell-cell Junction Protein-containing Complex Perinuclear Region Of Cytoplasm	Lysosome Endosome Golgi Apparatus Cytosol Plasma Membrane Endomembrane System Membrane Midbody Cytoplasmic Vesicle Membrane Lamellipodium Membrane Endolysosome Cell Projection Synapse Recycling Endosome Recycling Endosome Membrane Synaptic Membrane Bounding Membrane Of Organelle Schaffer Collateral - CA1 Synapse
	Molecular Function	Protein Binding Protein Homodimerization Activity GTPase Binding	Nucleotide Binding Magnesium Ion Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding
	Biological Process	Angiogenesis Vasculogenesis Signal Transduction Negative Regulation Of Autophagy Positive Regulation Of Integrin Activation Negative Regulation Of Rho Protein Signal Transduction Regulation Of GTPase Activity Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Membrane Permeability Negative Regulation Of Rho-dependent Protein Serine/threonine Kinase Activity	Signal Transduction Intracellular Protein Localization Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Rap Protein Signal Transduction Establishment Of Protein Localization Regulation Of JNK Cascade Regulation Of Dendrite Morphogenesis Regulation Of Synapse Assembly Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Microvillus Assembly
Drugs		None	Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate
GWAS		Alcohol consumption ( 31358974 ) Alcohol use disorder (total score) ( 30336701 ) Aspartate aminotransferase levels ( 33547301 ) Bipolar disorder ( 21926972 ) Blood protein levels in cardiovascular risk ( 28369058 ) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809 ) Cooked vegetable consumption ( 32066663 ) Crohn's disease ( 21102463 28067908 ) Dietary macronutrient intake ( 23372041 ) Estimated glomerular filtration rate ( 31015462 ) Fish- and plant-related diet ( 32066663 ) Fruit consumption ( 32066663 ) Inflammatory bowel disease ( 28067908 ) Inflammatory skin disease ( 25574825 ) Lipoprotein (a) levels ( 33730874 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Mean platelet volume ( 27863252 32888494 ) Meat-related diet ( 32066663 ) Non-oily fish consumption ( 32066663 ) Oily fish consumption ( 32066663 ) Platelet count ( 32888494 ) Pork consumption ( 32066663 ) Processed meat consumption ( 32066663 ) Retinal vascular caliber ( 21060863 ) Urinary albumin-to-creatinine ratio ( 31511532 ) Vitamin B levels in ischemic stroke ( 25147783 ) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226 )	Gut microbiota (bacterial taxa) ( 27723756 ) Peripheral artery disease ( 26488411 )
Interacting Genes		9 interacting genes: ARFGAP1 HRAS LDB2 MRAS RAP1A RAP2A RRAS RRAS2 UBC	32 interacting genes: ACVR1 AFDN ARHGAP29 BMPR1B EEF1A1 ENSA FKBP2 FNTB FTL GABARAPL2 GRIN1 GRIN2D MAP4K4 NEDD4 PLG RAB40B RAF1 RALGDS RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASIP1 RASSF5 RGS14 RRP9 RUNDC3A SERPINA1 SMAD1 TGFBR1 TM7SF2 TNIK
Entrez ID		54922	5911
HPRD ID		15214	01547
Ensembl ID		ENSG00000105538	ENSG00000125249
Uniprot IDs		Q5U651 Q7L251 Q8IUR2	P10114
PDB IDs		5KHO 5KHQ	1KAO 2RAP 3RAP
GO Terms Enriched among Interactors		GDP Binding Small GTPase-mediated Signal Transduction GTPase Activity GTP Binding G Protein Activity Ras Protein Signal Transduction Schwann Cell Migration Intracellular Signaling Cassette Rap Protein Signal Transduction Positive Regulation Of Vasculogenesis Regulation Of Vasculogenesis Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Hydrolase Activity Regulation Of Glial Cell Migration Regulation Of Cell Migration Nucleotide Binding Regulation Of Cell Motility Intracellular Signal Transduction Regulation Of Protein Localization To Synapse Regulation Of Locomotion Regulation Of Receptor Localization To Synapse Glial Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Plasma Membrane Regulation Of MAPK Cascade Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cell Projection Organization GTPase Complex Response To Antineoplastic Agent Phospholipase C Activator Activity Negative Regulation Of Schwann Cell Migration Positive Regulation Of Schwann Cell Migration Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Component Biogenesis Regulation Of JNK Cascade Positive Regulation Of Microvillus Assembly Regulation Of Protein Localization To Cell Periphery Oncogene-induced Cell Senescence Golgi Membrane Regulation Of Protein Localization To Membrane Golgi Apparatus Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Synaptic Vesicle Exocytosis Guanyl-nucleotide Exchange Factor Complex Positive Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin Negative Regulation Of Glial Cell Migration LIM Domain Binding	Intracellular Signaling Cassette Signal Transduction Transforming Growth Factor Beta Receptor Activity, Type I Intracellular Signal Transduction Ras Protein Signal Transduction Small GTPase-mediated Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Activity Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling GTPase Regulator Activity Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Microvillus Assembly Protein Kinase Activity Establishment Of Endothelial Barrier Activin Receptor Complex Activin Receptor Activity, Type I NMDA Glutamate Receptor Activity Glutamate Binding Endothelial Cell Development Guanyl-nucleotide Exchange Factor Activity BMP Receptor Activity Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition SMAD Binding NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity Positive Regulation Of Signal Transduction Kinase Activity Potassium Channel Inhibitor Activity Excitatory Chemical Synaptic Transmission Regulation Of Microvillus Assembly Activin Binding Cellular Response To Growth Factor Stimulus Enzyme-linked Receptor Protein Signaling Pathway Plasma Membrane Regulation Of Type B Pancreatic Cell Proliferation Regulation Of Intracellular Signal Transduction Protein Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction Nucleotide Binding Regulation Of Insulin Secretion Response To Growth Factor Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Osteoblast Differentiation Regulation Of Cartilage Development Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway I-SMAD Binding Positive Regulation Of Cellular Component Biogenesis