BCOR and NACC1

Number of citations: 0 (PubMedID 19121354)
Data Source: BioGRID (two hybrid)

		BCOR	NACC1
Name		BCL6 corepressor	nucleus accumbens associated 1
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm BCOR Complex	Nucleus Nucleoplasm Cytoplasm Cell Junction Nuclear Lumen
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Corepressor Activity Ubiquitin-protein Transferase Activity Protein Binding Heat Shock Protein Binding Histone Deacetylase Binding DNA-binding Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Histone Deacetylase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Blastocyst Hatching Chromatin Organization Chromatin Remodeling Heart Development Negative Regulation Of Bone Mineralization Odontogenesis Negative Regulation Of DNA-templated Transcription Roof Of Mouth Development Specification Of Axis Polarity Negative Regulation Of Tooth Mineralization	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Regulation Of Cell Population Proliferation Negative Regulation Of DNA-templated Transcription
Diseases		Anophthalmia and microphthalmia (A/M)	None
GWAS		Pit-and-Fissure caries ( 23470693 ) Platelet count ( 29403010 ) Refractive error ( 32231278 ) Venous thromboembolism ( 31676865 )	Obesity-related traits ( 23251661 )
Interacting Genes		16 interacting genes: BCL6 CPNE1 CPNE2 CPNE4 HDAC1 HDAC3 HDAC4 HDAC5 HDAC6 MLLT3 NAA10 NACC1 SP1 UBTD1 USP7 ZBTB5	20 interacting genes: BCOR C8orf33 CCNB1 EHHADH ELOA HDAC3 HDAC4 LGALS8 LSM3 PML POLR2L PRKCI PRPF18 PRPF3 SENP1 SENP2 TARDBP UBE2I UBTFL1 ZNF512B
Entrez ID		54880	112939
HPRD ID		06458	10692
Ensembl ID		ENSG00000183337	ENSG00000160877
Uniprot IDs		H7BZ37 H7C231 Q6W2J9	Q96RE7
PDB IDs		2N1L 3BIM 4HPL 6B7G 8HCU	3GA1 4U2N 7BV9 8YZS
GO Terms Enriched among Interactors		Histone Deacetylase Activity, Hydrolytic Mechanism Protein Lysine Deacetylase Activity Histone Deacetylase Activity Histone Deacetylase Binding Negative Regulation Of Gene Expression, Epigenetic Histone Deacetylase Complex Protein Deacetylation Transcription Corepressor Binding Negative Regulation Of Myotube Differentiation Epigenetic Regulation Of Gene Expression Macromolecule Deacylation Negative Regulation Of Striated Muscle Cell Differentiation Regulation Of Myotube Differentiation Chromatin Organization Transcription Repressor Complex DNA-binding Transcription Factor Binding Negative Regulation Of Muscle Cell Differentiation Chromatin Remodeling Regulation Of Striated Muscle Cell Differentiation Protein Lysine Delactylase Activity Negative Regulation Of Gene Expression NF-kappaB Binding Negative Regulation Of Macromolecule Biosynthetic Process Protein Decrotonylase Activity Histone Decrotonylase Activity Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Muscle Cell Differentiation Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of RNA Metabolic Process Calcium-dependent Phospholipid Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Differentiation RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Deacetylase Activity Cellular Response To Parathyroid Hormone Stimulus Cellular Response To Calcium Ion Nucleus Chromatin Binding Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Rhythmic Process Transcription Cis-regulatory Region Binding	Protein Sumoylation Nucleoplasm Regulation Of RNA Metabolic Process SUMO Transferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process U4/U6 X U5 Tri-snRNP Complex SUMO-specific Endopeptidase Activity Nucleus DeSUMOylase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Desumoylation Histone Deacetylase Activity, Hydrolytic Mechanism Regulation Of Gene Expression RNA Metabolic Process Protein Deacetylation Protein Lysine Deacetylase Activity Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Transcription By RNA Polymerase I Negative Regulation Of Myotube Differentiation Histone Deacetylase Activity Negative Regulation Of Macromolecule Metabolic Process PML Body Regulation Of Circadian Rhythm Negative Regulation Of Macromolecule Biosynthetic Process Maintenance Of Protein Location In Nucleus Macromolecule Deacylation Negative Regulation Of Metabolic Process Positive Regulation Of Post-translational Protein Modification Histone Deacetylase Binding Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Presynaptic Cytosol Postsynaptic Cytosol Positive Regulation Of MRNA Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process RNA Splicing Regulation Of Protein Stability Response To DDT Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Interleukin-1 Production Negative Regulation Of Translation In Response To Oxidative Stress Negative Regulation Of Catabolic Process Maintenance Of Protein Localization In Organelle Regulation Of Transcription By RNA Polymerase I SUMO Conjugating Enzyme Activity