SLX1A and ERCC4

Number of citations: 65 (PubMedID 19596236)
Data Source: BioGRID (pull down)

		SLX1A	ERCC4
Name		structure-specific endonuclease subunit SLX1A	ERCC excision repair 4, endonuclease catalytic subunit
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Slx1-Slx4 Complex	Nucleotide-excision Repair Complex Nucleotide-excision Repair Factor 1 Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome ERCC4-ERCC1 Complex
	Molecular Function	Nuclease Activity Endonuclease Activity Protein Binding Zinc Ion Binding Crossover Junction DNA Endonuclease Activity Hydrolase Activity 5'-flap Endonuclease Activity Metal Ion Binding	Single-stranded DNA Endodeoxyribonuclease Activity TFIID-class Transcription Factor Complex Binding DNA Binding Damaged DNA Binding Single-stranded DNA Binding Nuclease Activity Endonuclease Activity DNA Endonuclease Activity Protein Binding Telomerase Inhibitor Activity Hydrolase Activity Identical Protein Binding 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity Promoter-specific Chromatin Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination DNA Damage Response DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Telomere Maintenance Via Telomere Lengthening Regulation Of Telomere Maintenance Telomeric D-loop Disassembly T-circle Formation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of T-circle Formation	Resolution Of Meiotic Recombination Intermediates Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Repair Nucleotide-excision Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Damage Response Response To UV UV Protection Regulation Of Autophagy Negative Regulation Of Telomere Maintenance Cellular Response To UV Telomeric DNA-containing Double Minutes Formation Nucleotide-excision Repair Involved In Interstrand Cross-link Repair Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Protection From Non-homologous End Joining At Telomere
Pathways		Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway	HDR through Single Strand Annealing (SSA) Formation of Incision Complex in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Fanconi Anemia Pathway
Diseases		None	Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Brain morphology (MOSTest) ( 32665545 )	Alcohol consumption (drinks per week) ( 30643258 ) Asthma ( 27611488 ) Asthma (childhood onset) ( 27611488 ) Bilirubin levels ( 22085899 ) Bipolar disorder lithium response (categorical) or schizophrenia ( 29121268 ) Bitter alcoholic beverage consumption ( 31046077 ) Bone mineral density (total hip) ( 29883787 ) Conduct disorder (symptom count) ( 20585324 ) Egg allergy ( 25710614 ) Emphysema imaging phenotypes ( 26030696 ) Metabolic syndrome ( 20694148 ) Night sleep phenotypes ( 27126917 ) Number of sexual partners ( 30643258 ) Risk-taking tendency (4-domain principal component model) ( 30643258 ) Schizophrenia ( 29483656 28991256 30285260 25056061 ) Smoking status (ever vs never smokers) ( 30643258 ) Triglyceride levels ( 31170924 )
Interacting Genes		6 interacting genes: EME1 ERCC1 ERCC4 GRB2 MUS81 SLX4	12 interacting genes: ERCC1 FANCG GTF2H1 KIF11 RAD52 RPA1 RPA2 SLX1A SLX4 SPTAN1 SUMO2 TACC1
Entrez ID		548593	2072
HPRD ID		18681	00594
Ensembl ID		ENSG00000132207	ENSG00000175595
Uniprot IDs		Q9BQ83	A0A1W1GSK9 A0A804HKF9 B4DXD8 Q92889
PDB IDs		Not available	1Z00 2A1J 2AQ0 2KN7 2MUT 6SXA 6SXB
GO Terms Enriched among Interactors		Resolution Of Meiotic Recombination Intermediates ERCC4-ERCC1 Complex Telomere Maintenance Response To Intra-S DNA Damage Checkpoint Signaling Holliday Junction Resolvase Complex Telomere Organization Response To DNA Damage Checkpoint Signaling Double-strand Break Repair DNA Recombination Meiosis I Cell Cycle Process DNA Damage Response Chromosome Organization DNA Repair Chromosome, Telomeric Region Negative Regulation Of Telomere Maintenance Telomeric DNA-containing Double Minutes Formation Nucleotide-excision Repair Factor 1 Complex Negative Regulation Of Protection From Non-homologous End Joining At Telomere Nucleotide-excision Repair Positive Regulation Of T-circle Formation Negative Regulation Of Telomere Maintenance In Response To DNA Damage 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity Cellular Response To Stress Endodeoxyribonuclease Complex DNA Metabolic Process Resolution Of Mitotic Recombination Intermediates Nucleotide-excision Repair Complex Negative Regulation Of Chromosome Organization Negative Regulation Of Telomere Capping Resolution Of DNA Recombination Intermediates Crossover Junction DNA Endonuclease Activity Single-stranded DNA Endodeoxyribonuclease Activity TFIID-class Transcription Factor Complex Binding Regulation Of Telomere Maintenance T-circle Formation UV Protection Nuclease Activity Negative Regulation Of DNA Metabolic Process Telomere Maintenance Via Recombination Regulation Of Telomere Capping Double-strand Break Repair Via Homologous Recombination Organelle Organization Recombinational Repair Signal Transduction In Response To DNA Damage Mitotic Intra-S DNA Damage Checkpoint Signaling Reproductive Process Mitotic Recombination Nuclear Replication Fork Cellular Response To Radiation DNA Endonuclease Activity	Nucleotide-excision Repair DNA Repair Positive Regulation Of T-circle Formation DNA Metabolic Process Double-strand Break Repair Telomere Maintenance DNA Recombination DNA Damage Response DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Telomere Organization Double-strand Break Repair Via Homologous Recombination Recombinational Repair T-circle Formation Damaged DNA Binding DNA Double-strand Break Processing Single-stranded DNA Binding Slx1-Slx4 Complex Cellular Response To Stress Negative Regulation Of Telomere Maintenance Chromosome Organization ERCC4-ERCC1 Complex Organelle Organization Chromosome, Telomeric Region Nucleic Acid Metabolic Process Regulation Of DNA Metabolic Process Positive Regulation Of Telomere Maintenance Telomeric D-loop Disassembly Negative Regulation Of Chromosome Organization G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly DNA Replication Factor A Complex Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance PML Body Nucleobase-containing Compound Metabolic Process Mitotic Recombination Negative Regulation Of DNA Metabolic Process DNA Replication Nucleus Nuclear Thyroid Hormone Receptor Binding Mismatch Repair Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Nucleoplasm Telomere Maintenance Via Telomere Lengthening Base-excision Repair Response To Stress Interstrand Cross-link Repair Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Via Telomere Lengthening Double-strand Break Repair Via Single-strand Annealing