MFSD6 and HIBCH

Data Source: HiPPIP (Novel)

		MFSD6	HIBCH
Name		major facilitator superfamily domain containing 6	3-hydroxyisobutyryl-CoA hydrolase
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Mitochondrion Mitochondrial Matrix
	Molecular Function	Protein Binding	3-hydroxyisobutyryl-CoA Hydrolase Activity Hydrolase Activity
	Biological Process	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I	L-valine Catabolic Process Branched-chain Amino Acid Catabolic Process
Pathways		None	Branched-chain amino acid catabolism 3-hydroxyisobutyryl-CoA hydrolase deficiency
Drugs		None	Quercetin
Diseases		None	Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Arthritis (juvenile idiopathic) ( 33106285 ) Daytime sleep phenotypes ( 27126917 ) Estimated glomerular filtration rate ( 31015462 ) Medication use (thyroid preparations) ( 31015401 ) Platelet count ( 32888494 )	Blood protein levels ( 30072576 ) Daytime sleep phenotypes ( 27126917 ) Lung cancer (SNP x SNP interaction) ( 24325914 ) Urinary metabolite levels in chronic kidney disease ( 31959995 ) Urinary metabolites ( 26352407 )
Novel Interactors		7 novel interactors: AKAP19 ANKAR HIBCH MSTN OSGEPL1 STAT1 WDR75	1 novel interactors: MFSD6
Interacting Genes		37 interacting genes: ADIPOQ ALG8 APH1A APOL3 AQP7 C19orf18 CD79A CYB5R3 EBP ERGIC3 FAM209A GJA8 GJB2 GPR152 GPR42 GPX8 LY6E NKG7 PDCD1LG2 SELENOK SGPL1 SHISAL1 SLC10A1 SLC10A6 SLC16A2 SLC18A1 SLC39A2 SLC60A2 SMIM1 SSMEM1 STX12 SYNDIG1 TMEM179B TMEM237 TMEM242 TMEM258 TSPO2	None recorded
Entrez ID		54842	26275
HPRD ID		13369	11023
Ensembl ID		ENSG00000151690	ENSG00000198130
Uniprot IDs		B7Z7Y2 Q6ZSS7	A0A140VJL0 Q6NVY1
PDB IDs		Not available	3BPT
GO Terms Enriched among Interactors		Membrane Organic Hydroxy Compound Transport Bile Acid:sodium Symporter Activity Gap Junction-mediated Intercellular Transport	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Antigen Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation