GRAMD1C and CD151

Number of citations: 71 (PubMedID 29892012)
Data Source: BioGRID (two hybrid, two hybrid, two hybrid, two hybrid)

		GRAMD1C	CD151
Name		GRAM domain containing 1C	CD151 molecule (Raph blood group)
Structure			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Organelle Membrane Contact Site Endoplasmic Reticulum-plasma Membrane Contact Site	Basement Membrane Cytosol Plasma Membrane Focal Adhesion Cell Surface Membrane
	Molecular Function	Protein Binding Lipid Binding Cholesterol Binding Cholesterol Transfer Activity	Integrin Binding Protein Binding
	Biological Process	Lipid Transport Intracellular Sterol Transport Cellular Response To Cholesterol	Cell Adhesion Cell Migration Positive Regulation Of Cell Migration T Cell Proliferation Wound Healing, Spreading Of Cells Positive Regulation Of Endocytosis
Pathways		None	Assembly of collagen fibrils and other multimeric structures Type I hemidesmosome assembly
Diseases		None	Nephropathy with pretibial epidermolysis bullosa and deafness
GWAS		Blood protein levels ( 30072576 ) Lateral ventricle temporal horn volume ( 31530798 )	Mean platelet volume ( 27863252 32888494 ) Platelet count ( 32888494 )
Interacting Genes		3 interacting genes: APP CD151 CD72	12 interacting genes: ARL13B BCL7A GRAMD1C ITGA3 ITGA6 ITGB1 KLRC1 MMP7 PTGFRN RNF128 TMEM139 TSPAN18
Entrez ID		54762	977
HPRD ID		13187	03763
Ensembl ID		ENSG00000178075	ENSG00000177697
Uniprot IDs		B3KUR5 Q8IYS0	P48509 Q6ZNZ0
PDB IDs		6GN5	Not available
GO Terms Enriched among Interactors		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Signaling Receptor Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Integrin Binding Cell Surface Regulation Of Immune Response Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Positive Regulation Of Endocytosis Growth Cone Filopodium Cell Adhesion Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Regulation Of Endocytosis Peptidase Activator Activity Cellular Response To Manganese Ion Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding	Integrin Alpha6-beta1 Complex Integrin Alpha3-beta1 Complex Integrin Complex Formation Of Radial Glial Scaffolds Cell-matrix Adhesion Integrin-mediated Signaling Pathway Mesodermal Cell Differentiation Laminin Binding Negative Regulation Of Rho Protein Signal Transduction Cell-substrate Adhesion Myoblast Fusion Fibronectin Binding Receptor Complex Syncytium Formation By Plasma Membrane Fusion Cell-cell Fusion Syncytium Formation Positive Regulation Of Cell Migration Positive Regulation Of Locomotion Positive Regulation Of Cell Motility Integrin Alpha6-beta4 Complex Myoblast Fate Specification Integrin Alpha7-beta1 Complex Inhibitory MHC Class Ib Receptor Activity Antibacterial Peptide Secretion Signaling Receptor Activity Cell Surface Negative Regulation Of Small GTPase Mediated Signal Transduction Synaptic Membrane Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Cell Periphery Neuromuscular Junction Positive Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Integrin Alpha8-beta1 Complex Integrin Alpha1-beta1 Complex Integrin Alpha5-beta1 Complex Integrin Alpha10-beta1 Complex Integrin Alphav-beta1 Complex Integrin Alpha11-beta1 Complex Cardiac Cell Fate Specification Integrin Alpha9-beta1 Complex HLA-E Specific Inhibitory MHC Class Ib Receptor Activity External Side Of Plasma Membrane Positive Regulation Of GTPase Activity Growth Cone Filopodium Regulation Of Rho Protein Signal Transduction Positive Regulation Of Protein Localization To Membrane Integrin Alpha4-beta1 Complex Integrin Alpha2-beta1 Complex Natural Killer Cell Inhibitory Signaling Pathway CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation