UGT1A1 and UGDH

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		UGT1A1	UGDH
Name		UDP glucuronosyltransferase family 1 member A1	UDP-glucose 6-dehydrogenase
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Endoplasmic Reticulum Chaperone Complex Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytosol Extracellular Exosome
	Molecular Function	Retinoic Acid Binding Enzyme Inhibitor Activity Steroid Binding Protein Binding UDP-glycosyltransferase Activity Glucuronosyltransferase Activity Transferase Activity Glycosyltransferase Activity Enzyme Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Catalytic Activity UDP-glucose 6-dehydrogenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Identical Protein Binding NAD Binding
	Biological Process	Lipid Metabolic Process Bilirubin Conjugation Xenobiotic Metabolic Process Steroid Metabolic Process Estrogen Metabolic Process Flavonoid Metabolic Process Retinoic Acid Metabolic Process Negative Regulation Of Fatty Acid Metabolic Process Negative Regulation Of Steroid Metabolic Process Flavone Metabolic Process	Gastrulation With Mouth Forming Second Glycosaminoglycan Biosynthetic Process UDP-glucuronate Biosynthetic Process Heparan Sulfate Proteoglycan Biosynthetic Process Protein Hexamerization Neuron Development Chondroitin Sulfate Proteoglycan Biosynthetic Process
Pathways		Glucuronidation Heme degradation Defective UGT1A1 causes hyperbilirubinemia Aspirin ADME Paracetamol ADME	Formation of the active cofactor, UDP-glucuronate
Drugs		Fostamatinib	NADH Copper
Diseases		Hyperbilirubinemia; Crigler-Najjar syndrome, type I (CN1); Crigler-Najjar syndrome, type II (CN2); Gilbert Syndrome; Dubin-Johnson syndrome (DJS)	None
GWAS		Bilirubin levels ( 19419973 20639394 22085899 31801373 23371916 19414484 ) Bilirubin levels in extreme obesity ( 25246029 ) Cholelithiasis-related traits in sickle cell anemia ( 22558097 ) Cholesterol, total ( 24097068 ) Circulating cell-free DNA ( 22511988 ) Hair greying ( 26926045 ) LDL cholesterol ( 24097068 ) LDL cholesterol levels ( 28334899 ) Low density lipoprotein cholesterol levels ( 32154731 ) Serum bilirubin levels in metabolic syndrome ( 30621171 ) Serum metabolite levels ( 23093944 ) Total bilirubin levels ( 29403010 34117260 ) Total bilirubin levels in HIV-1 infection ( 25884002 )	Haemorrhoidal disease ( 33888516 ) Response to tofacitinib treatment in psoriasis (herpes zoster) ( 33455090 ) Response to tofacitinib treatment in psoriasis (herpes zoster)(time to event) ( 33455090 )
Interacting Genes		3 interacting genes: COPZ1 SEC23B UGDH	7 interacting genes: AK5 ANXA1 CDC42 ITGB1BP2 LINC00632 RAD51 UGT1A1
Entrez ID		54658	7358
HPRD ID		08933	04535
Ensembl ID		ENSG00000241635	ENSG00000109814
Uniprot IDs		P22309 Q5DT03	O60701
PDB IDs		Not available	2Q3E 2QG4 3ITK 3KHU 3PRJ 3PTZ 3TDK 3TF5 4EDF 4RJT 5TJH 5VR8 5W4X 6C4J 6C4K 6C58 6C5A 6C5Z 9DGZ
GO Terms Enriched among Interactors		UDP-glucuronate Biosynthetic Process UDP-glucose 6-dehydrogenase Activity UDP-glucuronate Metabolic Process COPII-coated Vesicle Budding Protein Transport GTPase Activator Activity Establishment Of Protein Localization Golgi Vesicle Transport Postsynaptic Endosome Heparan Sulfate Proteoglycan Biosynthetic Process Gastrulation With Mouth Forming Second Protein Hexamerization Chondroitin Sulfate Proteoglycan Biosynthetic Process Glycosaminoglycan Biosynthetic Process Intracellular Protein Localization COPII Vesicle Coat COPII-coated Vesicle Cargo Loading COPI-coated Vesicle Membrane COPI Vesicle Coat Regulation Of Modification Of Synaptic Structure Regulation Of Modification Of Postsynaptic Structure Chondroitin Sulfate Proteoglycan Metabolic Process Intracellular Protein Transport Nucleotide-sugar Biosynthetic Process Heparan Sulfate Proteoglycan Metabolic Process Vesicle Cargo Loading Endoplasmic Reticulum Exit Site Membrane Coat NAD Binding Vesicle Budding From Membrane Intra-Golgi Vesicle-mediated Transport Nucleotide-sugar Metabolic Process Glycosaminoglycan Metabolic Process Gastrulation Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Proteoglycan Biosynthetic Process Cytoplasmic Vesicle ER To Golgi Transport Vesicle Membrane	None