UGT1A1 and COPZ1

Number of citations: 69 (PubMedID 9472029)
Data Source: BioGRID (unspecified method)

		UGT1A1	COPZ1
Name		UDP glucuronosyltransferase family 1 member A1	coat protein complex I subunit zeta 1
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Endoplasmic Reticulum Chaperone Complex Perinuclear Region Of Cytoplasm	Golgi Membrane Cytoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Membrane Coat COPI Vesicle Coat Transport Vesicle COPI-coated Vesicle Membrane Cytoplasmic Vesicle
	Molecular Function	Retinoic Acid Binding Enzyme Inhibitor Activity Steroid Binding Protein Binding UDP-glycosyltransferase Activity Glucuronosyltransferase Activity Transferase Activity Glycosyltransferase Activity Enzyme Binding Protein Homodimerization Activity Protein Heterodimerization Activity	None
	Biological Process	Lipid Metabolic Process Bilirubin Conjugation Xenobiotic Metabolic Process Steroid Metabolic Process Estrogen Metabolic Process Flavonoid Metabolic Process Retinoic Acid Metabolic Process Negative Regulation Of Fatty Acid Metabolic Process Negative Regulation Of Steroid Metabolic Process Flavone Metabolic Process	Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Intra-Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport
Pathways		Glucuronidation Heme degradation Defective UGT1A1 causes hyperbilirubinemia Aspirin ADME Paracetamol ADME	COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs		Fostamatinib	None
Diseases		Hyperbilirubinemia; Crigler-Najjar syndrome, type I (CN1); Crigler-Najjar syndrome, type II (CN2); Gilbert Syndrome; Dubin-Johnson syndrome (DJS)	None
GWAS		Bilirubin levels ( 19419973 20639394 22085899 31801373 23371916 19414484 ) Bilirubin levels in extreme obesity ( 25246029 ) Cholelithiasis-related traits in sickle cell anemia ( 22558097 ) Cholesterol, total ( 24097068 ) Circulating cell-free DNA ( 22511988 ) Hair greying ( 26926045 ) LDL cholesterol ( 24097068 ) LDL cholesterol levels ( 28334899 ) Low density lipoprotein cholesterol levels ( 32154731 ) Serum bilirubin levels in metabolic syndrome ( 30621171 ) Serum metabolite levels ( 23093944 ) Total bilirubin levels ( 29403010 34117260 ) Total bilirubin levels in HIV-1 infection ( 25884002 )	Chronotype ( 30696823 ) Hematocrit ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Mean platelet volume ( 22139419 24026423 27863252 32888494 ) Meat-related diet ( 32066663 ) Platelet count ( 23263863 32888494 29403010 ) Platelet distribution width ( 32888494 ) Plateletcrit ( 32888494 ) Red blood cell count ( 27863252 32888494 ) Red cell distribution width ( 27863252 32888494 ) Refractive error ( 32231278 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )
Interacting Genes		3 interacting genes: COPZ1 SEC23B UGDH	6 interacting genes: APP COPG1 COPG2 TMED10 TMED9 UGT1A1
Entrez ID		54658	22818
HPRD ID		08933	16738
Ensembl ID		ENSG00000241635	ENSG00000111481
Uniprot IDs		P22309 Q5DT03	P61923
PDB IDs		Not available	2HF6 5MC7
GO Terms Enriched among Interactors		UDP-glucuronate Biosynthetic Process UDP-glucose 6-dehydrogenase Activity UDP-glucuronate Metabolic Process COPII-coated Vesicle Budding Protein Transport GTPase Activator Activity Establishment Of Protein Localization Golgi Vesicle Transport Postsynaptic Endosome Heparan Sulfate Proteoglycan Biosynthetic Process Gastrulation With Mouth Forming Second Protein Hexamerization Chondroitin Sulfate Proteoglycan Biosynthetic Process Glycosaminoglycan Biosynthetic Process Intracellular Protein Localization COPII Vesicle Coat COPII-coated Vesicle Cargo Loading COPI-coated Vesicle Membrane COPI Vesicle Coat Regulation Of Modification Of Synaptic Structure Regulation Of Modification Of Postsynaptic Structure Chondroitin Sulfate Proteoglycan Metabolic Process Intracellular Protein Transport Nucleotide-sugar Biosynthetic Process Heparan Sulfate Proteoglycan Metabolic Process Vesicle Cargo Loading Endoplasmic Reticulum Exit Site Membrane Coat NAD Binding Vesicle Budding From Membrane Intra-Golgi Vesicle-mediated Transport Nucleotide-sugar Metabolic Process Glycosaminoglycan Metabolic Process Gastrulation Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Proteoglycan Biosynthetic Process Cytoplasmic Vesicle ER To Golgi Transport Vesicle Membrane	Endoplasmic Reticulum-Golgi Intermediate Compartment Transport Vesicle Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Golgi Vesicle Transport COPI Coating Of Golgi Vesicle Endoplasmic Reticulum Membrane Intracellular Transport Vesicle-mediated Transport COPI-coated Vesicle COPI Vesicle Coat Trans-Golgi Network Transport Vesicle Intracellular Protein Transport COPI-coated Vesicle Membrane Golgi Apparatus Transport Along Microtubule Golgi Membrane Cytoskeleton-dependent Intracellular Transport Cellular Localization Establishment Of Localization In Cell Microtubule-based Transport Membrane Coat Intra-Golgi Vesicle-mediated Transport Vesicle Coating COPII-coated ER To Golgi Transport Vesicle Cytoplasmic Vesicle Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Syntaxin Binding Regulation Of Amyloid Precursor Protein Catabolic Process Protein Transport Microtubule-based Movement Secretion By Cell Positive Regulation Of Interleukin-1 Production Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Cytosol To ERGIC Protein Transport Protein Localization To ERGIC COPI-coated Vesicle Budding Organelle Transport Along Microtubule Establishment Of Protein Localization Secretion Acetylcholine Receptor Activator Activity Regulation Of Interleukin-1 Production Lipoprotein Particle Positive Regulation Of Protein Import Golgi Organization