UGT1A1 and SEC23B

Number of citations: 69 (PubMedID 9472029)
Data Source: BioGRID (unspecified method)

		UGT1A1	SEC23B
Name		UDP glucuronosyltransferase family 1 member A1	SEC23 homolog B, COPII component
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Endoplasmic Reticulum Chaperone Complex Perinuclear Region Of Cytoplasm	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Endomembrane System ER To Golgi Transport Vesicle Membrane Membrane COPII Vesicle Coat Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Exit Site
	Molecular Function	Retinoic Acid Binding Enzyme Inhibitor Activity Steroid Binding Protein Binding UDP-glycosyltransferase Activity Glucuronosyltransferase Activity Transferase Activity Glycosyltransferase Activity Enzyme Binding Protein Homodimerization Activity Protein Heterodimerization Activity	GTPase Activator Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Lipid Metabolic Process Bilirubin Conjugation Xenobiotic Metabolic Process Steroid Metabolic Process Estrogen Metabolic Process Flavonoid Metabolic Process Retinoic Acid Metabolic Process Negative Regulation Of Fatty Acid Metabolic Process Negative Regulation Of Steroid Metabolic Process Flavone Metabolic Process	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport COPII-coated Vesicle Cargo Loading COPII-coated Vesicle Budding
Pathways		Glucuronidation Heme degradation Defective UGT1A1 causes hyperbilirubinemia Aspirin ADME Paracetamol ADME	None
Drugs		Fostamatinib	None
Diseases		Hyperbilirubinemia; Crigler-Najjar syndrome, type I (CN1); Crigler-Najjar syndrome, type II (CN2); Gilbert Syndrome; Dubin-Johnson syndrome (DJS)	Congenital dyserythropoietic anemias (CDAs)
GWAS		Bilirubin levels ( 19419973 20639394 22085899 31801373 23371916 19414484 ) Bilirubin levels in extreme obesity ( 25246029 ) Cholelithiasis-related traits in sickle cell anemia ( 22558097 ) Cholesterol, total ( 24097068 ) Circulating cell-free DNA ( 22511988 ) Hair greying ( 26926045 ) LDL cholesterol ( 24097068 ) LDL cholesterol levels ( 28334899 ) Low density lipoprotein cholesterol levels ( 32154731 ) Serum bilirubin levels in metabolic syndrome ( 30621171 ) Serum metabolite levels ( 23093944 ) Total bilirubin levels ( 29403010 34117260 ) Total bilirubin levels in HIV-1 infection ( 25884002 )	Refractive error ( 32231278 )
Interacting Genes		3 interacting genes: COPZ1 SEC23B UGDH	26 interacting genes: CPSF7 DTX2 FATE1 FBXW5 GALNT1 HOXA3 KDELR1 MAN2A1 PRRC1 RIN1 SEC24C SEC24D SKP1 SNRPC SRPK1 SRPK2 SYNE4 TMED1 TMED10 TMED2 TMED9 TRIM55 TRIM63 UBA52 UBC UGT1A1
Entrez ID		54658	10483
HPRD ID		08933	11543
Ensembl ID		ENSG00000241635	ENSG00000101310
Uniprot IDs		P22309 Q5DT03	A0A2R8YFH5 Q15437
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		UDP-glucuronate Biosynthetic Process UDP-glucose 6-dehydrogenase Activity UDP-glucuronate Metabolic Process COPII-coated Vesicle Budding Protein Transport GTPase Activator Activity Establishment Of Protein Localization Golgi Vesicle Transport Postsynaptic Endosome Heparan Sulfate Proteoglycan Biosynthetic Process Gastrulation With Mouth Forming Second Protein Hexamerization Chondroitin Sulfate Proteoglycan Biosynthetic Process Glycosaminoglycan Biosynthetic Process Intracellular Protein Localization COPII Vesicle Coat COPII-coated Vesicle Cargo Loading COPI-coated Vesicle Membrane COPI Vesicle Coat Regulation Of Modification Of Synaptic Structure Regulation Of Modification Of Postsynaptic Structure Chondroitin Sulfate Proteoglycan Metabolic Process Intracellular Protein Transport Nucleotide-sugar Biosynthetic Process Heparan Sulfate Proteoglycan Metabolic Process Vesicle Cargo Loading Endoplasmic Reticulum Exit Site Membrane Coat NAD Binding Vesicle Budding From Membrane Intra-Golgi Vesicle-mediated Transport Nucleotide-sugar Metabolic Process Glycosaminoglycan Metabolic Process Gastrulation Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Proteoglycan Biosynthetic Process Cytoplasmic Vesicle ER To Golgi Transport Vesicle Membrane	Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum To Golgi Vesicle-mediated Transport COPI Coating Of Golgi Vesicle Vesicle Cargo Loading Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Vesicle Transport COPII-coated ER To Golgi Transport Vesicle ER To Golgi Transport Vesicle Membrane Protein Modification Process Transport Vesicle Vesicle Coating Protein Ubiquitination Golgi Organization Maintenance Of Protein Localization In Organelle Cis-Golgi Network Endoplasmic Reticulum Protein Modification By Small Protein Conjugation Maintenance Of Protein Location In Cell Maintenance Of Protein Location Intracellular Protein Transport Maintenance Of Location In Cell COPI-coated Vesicle Post-translational Protein Modification Protein Tag Activity Maintenance Of Location COPII Vesicle Coat COPI-coated Vesicle Membrane Vesicle-mediated Transport Zymogen Granule Membrane Trans-Golgi Network Transport Vesicle COPII-coated Vesicle Cargo Loading Golgi Membrane In Utero Embryonic Development Chordate Embryonic Development COPII Vesicle Coating Golgi Apparatus Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Viral Protein Processing Endoplasmic Reticulum Exit Site Positive Regulation Of Viral Genome Replication Protein Transport Cytosol To ERGIC Protein Transport Protein Localization To ERGIC COPI-coated Vesicle Budding Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Protein Metabolic Process