DDX56 and USP33

Number of citations: 0 (PubMedID 16169070)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		DDX56	USP33
Name		DEAD-box helicase 56	ubiquitin specific peptidase 33
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytosol Membrane	Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Focal Adhesion VCB Complex Neuronal Cell Body Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity RNA Stem-loop Binding Protein Sequestering Activity	G Protein-coupled Receptor Binding Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Small GTPase Binding Ubiquitin Binding Metal Ion Binding
	Biological Process	Cytoplasmic Pattern Recognition Receptor Signaling Pathway RRNA Processing Protein Import Into Nucleus Positive Regulation Of Neuron Projection Development Negative Regulation Of Type I Interferon Production Ribosome Biogenesis Host-mediated Perturbation Of Viral RNA Genome Replication Defense Response To Virus	Proteolysis Ubiquitin-dependent Protein Catabolic Process Endocytosis Nervous System Development Axon Guidance Regulation Of G Protein-coupled Receptor Signaling Pathway Cell Migration Protein Deubiquitination Protein Stabilization Centrosome Duplication Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Positive Regulation Of Autophagosome Assembly
Pathways		None	Ub-specific processing proteases Regulation of expression of SLITs and ROBOs
GWAS		LDL cholesterol levels ( 30698716 ) LDL cholesterol levels in current drinkers ( 30698716 ) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 )	Adult body size ( 32376654 ) Post bronchodilator FEV1 ( 26634245 )
Interacting Genes		6 interacting genes: EHD2 EIF4A3 OGT SOX30 USP33 ZNF408	17 interacting genes: CCP110 CHRM5 DDX56 DIO2 DSCR9 EIF6 ELOC PRKN SELENBP1 SNCA TRIM54 TRIM63 UBC USP15 USP21 USP28 VHL
Entrez ID		54606	23032
HPRD ID		12154	10297
Ensembl ID		ENSG00000136271	ENSG00000077254
Uniprot IDs		Q9NY93	Q8TEY7
PDB IDs		Not available	2UZG
GO Terms Enriched among Interactors		Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Selenocysteine Incorporation Cellular Response To Selenite Ion Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Negative Regulation Of Translation Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Positive Regulation Of Translation Protein O-acetylglucosaminyltransferase Activity Selenocysteine Insertion Sequence Binding Negative Regulation Of Translational Elongation Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Regulation Of Translation At Postsynapse Proacrosomal Vesicle Fusion VCB Complex	Post-translational Protein Modification Dopamine Transport Monoamine Transport Protein Deubiquitination Amyloid Fibril Formation Protein Modification By Small Protein Removal Target-directed MiRNA Degradation Elongin Complex Protein Modification Process Dopamine Uptake Involved In Synaptic Transmission Protein Ubiquitination Protein Metabolic Process Selenium Binding Protein Modification By Small Protein Conjugation Catecholamine Uptake Dopamine Uptake Regulation Of ATP Metabolic Process MiRNA Catabolic Process Phenol-containing Compound Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Proteolysis Synaptic Transmission, Dopaminergic Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of MiRNA-mediated Gene Silencing Cul5-RING Ubiquitin Ligase Complex Cysteine-type Deubiquitinase Activity Macromolecule Metabolic Process Cul2-RING Ubiquitin Ligase Complex Ubiquitin Ligase Complex Neurotransmitter Reuptake Regulation Of Neurotransmitter Uptake Regulation Of Dopamine Metabolic Process Phospholipase Binding Regulation Of Phosphorus Metabolic Process Ubiquitin Protein Ligase Binding Regulation Of Dopamine Secretion MiRNA Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of MiRNA-mediated Gene Silencing Cysteine-type Peptidase Activity Deubiquitinase Activity Post-transcriptional Gene Silencing Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Post-transcriptional Gene Silencing Neurotransmitter Uptake Regulation Of Synaptic Vesicle Recycling Cytosol Dopamine Metabolic Process Regulation Of Protein Stability