POU3F3 and SOX8

Number of citations: 44 (PubMedID 16582099)
Data Source: HPRD (two hybrid)

		POU3F3	SOX8
Name		POU class 3 homeobox 3	SRY-box transcription factor 8
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Chromatin Nucleus Transcription Regulator Complex Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Homodimerization Activity Sequence-specific DNA Binding HMG Box Domain Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Sequence-specific DNA Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Kidney Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Central Nervous System Development Brain Development Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Cerebral Cortex Radially Oriented Cell Migration Forebrain Ventricular Zone Progenitor Cell Division Negative Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Chemical Homeostasis Urea Transmembrane Transport Metanephric Ascending Thin Limb Development Metanephric Macula Densa Development Metanephric Thick Ascending Limb Development Metanephric Loop Of Henle Development Metanephric DCT Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation In Utero Embryonic Development Neural Crest Cell Migration Morphogenesis Of An Epithelium Signal Transduction Spermatogenesis Peripheral Nervous System Development Male Gonad Development Positive Regulation Of Gene Expression Regulation Of Hormone Levels Positive Regulation Of Gliogenesis Neural Crest Cell Development Positive Regulation Of Osteoblast Proliferation Skeletal Muscle Cell Differentiation Negative Regulation Of Apoptotic Process Cell Fate Commitment Fat Cell Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Photoreceptor Cell Differentiation Cell Maturation Enteric Nervous System Development Oligodendrocyte Differentiation Sertoli Cell Development Astrocyte Fate Commitment Retina Development In Camera-type Eye Retinal Rod Cell Differentiation Adipose Tissue Development Morphogenesis Of A Branching Epithelium Renal Vesicle Induction Ureter Morphogenesis Metanephric Nephron Tubule Formation Positive Regulation Of Kidney Development Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis
Pathways		Nephron development	None
GWAS		Adult body size ( 32376654 ) Body mass index ( 26426971 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) General risk tolerance (MTAG) ( 30643258 ) Response to taxane treatment (docetaxel) ( 23006423 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 )	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Logical memory (immediate recall) in normal cognition ( 29274321 ) Multiple sclerosis ( 21833088 31604244 ) Polycystic ovary syndrome ( 25574032 )
Interacting Genes		5 interacting genes: POU3F4 PPP1R15A SOX10 SOX11 SOX8	18 interacting genes: CEBPA DLX5 EGR2 HHEX HOXC11 JAM2 JUN MMP1 NOD1 NR5A1 OLIG2 PAX3 PIDD1 POU3F3 POU5F1 SP1 TCF12 UTF1
Entrez ID		5455	30812
HPRD ID		03922	16175
Ensembl ID		ENSG00000198914	ENSG00000005513
Uniprot IDs		P20264	P57073
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Regulation Of Gliogenesis Sequence-specific Double-stranded DNA Binding Enteric Nervous System Development DNA-binding Transcription Factor Activity Negative Regulation Of Glial Cell Proliferation Oligodendrocyte Development Positive Regulation Of Neurogenesis Peripheral Nervous System Development Positive Regulation Of Nervous System Development DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Regulation Of Glial Cell Proliferation Negative Regulation Of Gliogenesis Oligodendrocyte Differentiation Morphogenesis Of An Epithelium Regulation Of Neurogenesis Neural Crest Cell Migration Mesenchymal Cell Migration Positive Regulation Of Gliogenesis Positive Regulation Of Gene Expression Glial Cell Development Tissue Morphogenesis Skeletal Muscle Cell Differentiation Positive Regulation Of Cell Development Regulation Of Nervous System Development Animal Organ Development Cis-regulatory Region Sequence-specific DNA Binding Anatomical Structure Morphogenesis Positive Regulation Of Lens Epithelial Cell Proliferation Glial Cell Differentiation Ameboidal-type Cell Migration Negative Regulation Of Cell Differentiation Closure Of Optic Fissure Negative Regulation Of Neurogenesis Negative Regulation Of Nervous System Development Morphogenesis Of A Branching Structure Morphogenesis Of A Branching Epithelium Cell Maturation Negative Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Translational Initiation In Response To Stress Eukaryotic Initiation Factor EIF2 Binding Renal Vesicle Induction DNA Binding Negative Regulation Of Apoptotic Process Regulation Of Cell Development Cell Development DNA-binding Transcription Factor Binding Positive Regulation Of Cell Differentiation Cellular Response To Progesterone Stimulus	Positive Regulation Of Transcription By RNA Polymerase II HMG Box Domain Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Positive Regulation Of RNA Metabolic Process Sequence-specific Double-stranded DNA Binding Transcription Cis-regulatory Region Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Positive Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Sequence-specific DNA Binding Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Animal Organ Development Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process RNA Polymerase II Transcription Regulator Complex Response To Gonadotropin-releasing Hormone Positive Regulation Of Developmental Process Cellular Developmental Process Regulation Of Metabolic Process Developmental Process Regulation Of Multicellular Organismal Process Regulation Of Developmental Process System Development CAMP Response Element Binding Nucleus Transcription Regulator Complex Positive Regulation Of Gene Expression Positive Regulation Of Multicellular Organismal Process Host-mediated Activation Of Viral Transcription Positive Regulation Of Canonical Wnt Signaling Pathway Nervous System Development Cell Differentiation Organ Induction Double-stranded DNA Binding