CCSER2 and EXOC1

Number of citations: 0 (PubMedID 17043677)
Data Source: BioGRID (two hybrid)

		CCSER2	EXOC1
Name		coiled-coil serine rich protein 2	exocyst complex component 1
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Microtubule Cytoskeleton	Exocyst Cytoplasm Cytosol Plasma Membrane Membrane Perinuclear Region Of Cytoplasm Flemming Body
	Molecular Function	Protein Binding Microtubule Binding	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding
	Biological Process	Microtubule Bundle Formation	Mitotic Cytokinesis Exocytosis Golgi To Plasma Membrane Transport Vesicle Docking Involved In Exocytosis Protein Transport Regulation Of Macroautophagy Defense Response To Virus Membrane Fission Vesicle Tethering Involved In Exocytosis
Pathways		None	Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium
GWAS		Cerebrospinal P-tau181p levels ( 28247064 ) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644 ) Refractive error ( 32231278 )	Cerebrospinal P-tau181p levels ( 28247064 ) Cervical cancer ( 23817570 ) Daytime sleep phenotypes ( 27126917 ) Urinary albumin excretion ( 32277301 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )
Interacting Genes		12 interacting genes: APP ATRX CRADD EXOC1 EXOSC8 GTF2H1 KIFAP3 MAP1LC3B OFD1 PSMD11 STX1A TCEA2	29 interacting genes: ATG14 CCDC88A CCDC93 CCSER2 CDC5L CEP295 COLEC12 DISC1 DST ITSN1 KANSL1 KDM1A LUC7L2 MACF1 MTNR1A NUF2 NUP54 RALA RB1CC1 RESF1 RUBCN SFR1 SH3BP5 SNCA SPTAN1 SRGAP2 SYBU TRAF3IP1 TRIO
Entrez ID		54462	55763
HPRD ID		13832	07615
Ensembl ID		ENSG00000107771	ENSG00000090989
Uniprot IDs		Q9H7U1	Q9NV70
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Protein-containing Complex Organization Axo-dendritic Transport Regulation Of Response To Calcium Ion Positive Regulation Of Excitatory Postsynaptic Potential Microtubule-based Transport Amylin Binding Endosome To Plasma Membrane Transport Vesicle Cellular Component Assembly Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Protein-containing Complex Assembly Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Modulation Of Excitatory Postsynaptic Potential Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Telomeric Post-embryonic Forelimb Morphogenesis Chromosome, Subtelomeric Region Vesicle Docking Involved In Exocytosis Membrane Docking Myosin Head/neck Binding Vesicle Docking Positive Regulation Of Norepinephrine Secretion Organelle Localization By Membrane Tethering Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Ciliary Basal Body Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Involved In Neural Plate Anterior/posterior Pattern Formation Death Domain Binding Endopeptidase Complex U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Kinesin II Complex Positive Regulation Of Calcium-dependent Cell-cell Adhesion Calcium:proton Antiporter Activity Calcium Export From The Mitochondrion Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Microtubule-based Process Regulation Of Apoptotic Signaling Pathway	Microtubule Binding Microtubule-based Process Cytoskeleton Organelle Organization Phosphatidylinositol 3-kinase Inhibitor Activity Microtubule Cytoskeleton Organization Regulation Of Cellular Component Organization Cellular Localization Cell Leading Edge Cell Projection Cytoskeleton Organization Positive Regulation Of Cell Size Regulation Of Cytoskeleton Organization Microtubule Molecular Adaptor Activity Cytoskeleton-dependent Intracellular Transport Positive Regulation Of Cell Projection Organization Actin Binding Cytoplasmic Vesicle Positive Regulation Of Cellular Component Organization Guanyl-nucleotide Exchange Factor Activity Intracellular Transport Regulation Of Organelle Organization Phagophore Assembly Site Membrane Establishment Of Localization In Cell Signal Transduction Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Regulation Of Synapse Organization Response To Desipramine Negative Regulation Of Norepinephrine Uptake Negative Regulation Of Protein-containing Complex Assembly Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Microtubule-based Process Negative Regulation Of Cellular Component Organization Phagophore Assembly Site Ribophagy Protein-membrane Adaptor Activity Extrinsic Component Of Phagophore Assembly Site Membrane Positive Regulation Of Neuroblast Proliferation Lamellipodium Assembly Extension Of A Leading Process Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Lamellipodium Assembly Involved In Ameboidal Cell Migration Regulation Of Endocytosis Positive Regulation Of Axon Extension