POMC and PAM

Number of citations: 0 (PubMedID 18052119)
Data Source: HPRD (in vivo)

		POMC	PAM
Name		proopiomelanocortin	peptidylglycine alpha-amidating monooxygenase
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Peroxisome Peroxisomal Matrix Secretory Granule Secretory Granule Lumen	Extracellular Region Membrane Transport Vesicle Membrane Secretory Granule Membrane Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Binding Signaling Receptor Binding Hormone Activity Protein Binding Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Type 1 Melanocortin Receptor Binding	Catalytic Activity Monooxygenase Activity Peptidylglycine Monooxygenase Activity Peptidylamidoglycolate Lyase Activity Copper Ion Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Ascorbate As One Donor, And Incorporation Of One Atom Of Oxygen Lyase Activity L-ascorbic Acid Binding Metal Ion Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Signal Transduction Neuropeptide Signaling Pathway Cell-cell Signaling Regulation Of Blood Pressure Calcium-mediated Signaling Killing Of Cells Of Another Organism Regulation Of Appetite Negative Regulation Of Tumor Necrosis Factor Production Cellular Pigmentation Modulation Of Process Of Another Organism Glucose Homeostasis Positive Regulation Of Transcription By RNA Polymerase II Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Regulation Of Glycogen Metabolic Process Positive Regulation Of Neutrophil Mediated Killing Of Fungus Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Oxytocin Production Response To Melanocyte-stimulating Hormone Regulation Of Corticosterone Secretion	Peptide Amidation Peptide Metabolic Process Lipid Metabolic Process Response To Zinc Ion Cellular Response To Oxidative Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Fatty Acid Primary Amide Biosynthetic Process
Pathways		Opioid Signalling Androgen biosynthesis Glucocorticoid biosynthesis G-protein activation Peptide hormone biosynthesis Endogenous sterols Peptide ligand-binding receptors G alpha (s) signalling events G alpha (i) signalling events Defective ACTH causes obesity and POMCD Interleukin-4 and Interleukin-13 signaling FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Transcriptional and post-translational regulation of MITF-M expression and activity	None
Drugs		Loperamide Etorphine Dihydromorphine	Ascorbic acid N-Alpha-Acetyl-3,5-Diiodotyrosylglycine N-alpha-Acetyl-3,5-diiodotyrosyl-D-threonine
GWAS		Body mass index ( 20935630 23669352 26426971 ) Body mass index (age <50) ( 26426971 ) Body mass index (age>50) ( 26426971 ) Body mass index x sex x age interaction (4df test) ( 26426971 ) Crohn's disease ( 28067908 ) Height ( 18391951 23563607 28552196 ) Hip circumference adjusted for BMI ( 34021172 ) Inflammatory bowel disease ( 28067908 ) Obesity ( 23563607 ) Pubertal anthropometrics ( 23449627 ) Red vs. brown/black hair color ( 30531825 ) Type 1 diabetes ( 21980299 )	Appendicular lean mass ( 33097823 ) Blood protein levels ( 30072576 ) Daytime nap ( 33568662 ) Diastolic blood pressure ( 29208002 ) Early cardiac repolarization ( 31600170 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Feeling worry ( 29500382 ) Insulinogenic index ( 23263489 ) Medication use (drugs used in diabetes) ( 31015401 ) Nicotine dependence symptom count ( 25555482 ) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892 ) PR interval ( 30046033 32439900 ) Primary biliary cholangitis ( 26394269 ) Refractive error ( 32231278 ) Sleep duration (short sleep) ( 30846698 ) Systolic blood pressure ( 29208002 ) Type 2 diabetes ( 30054458 30297969 29632382 29358691 ) Type 2 diabetes (adjusted for BMI) ( 29632382 ) Waist-hip index ( 34021172 )
Interacting Genes		28 interacting genes: ABI2 AIRIM APP ATP6V0D2 BHLHA9 CCDC102B ESRRG FGF10 GLYCTK HDDC2 HLA-DRB3 HSF2BP KLHL42 MC1R MC2R MC3R MC4R MC5R MEP1A MKRN3 NFKBID NRDC NTAQ1 OAZ3 PAM SUOX TXN2 VTN	9 interacting genes: CALM1 FXYD1 GLP1R KALRN POMC PRKCA RASSF9 TSC2 UHMK1
Entrez ID		5443	5066
HPRD ID		01462	01361
Ensembl ID		ENSG00000115138	ENSG00000145730
Uniprot IDs		P01189	A0A804HIQ0 A0A804HKM7 A0A804HKV8 A0A8C8KD64 O43832 P19021
PDB IDs		4XNH 4XPD 4Y49 6TUB 7F53 7F54 7PIV 8F7Q 8INR 8IOC	Not available
GO Terms Enriched among Interactors		Melanocortin Receptor Activity Melanocyte-stimulating Hormone Receptor Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Feeding Behavior Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Hormone Binding G Protein-coupled Receptor Activity Regulation Of Behavior Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Chemoattractant Activity Amylin Binding Positive Regulation Of Toll Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Multicellular Organismal Process Protein Binding Protein Serine/threonine Kinase Binding Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Urothelial Cell Proliferation Lung Proximal/distal Axis Specification Bronchiole Morphogenesis Urothelial Cell Proliferation Embryonic Genitalia Morphogenesis Semicircular Canal Fusion Mesenchymal-epithelial Cell Signaling Involved In Lung Development Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Submandibular Salivary Gland Formation Corticotropin Receptor Activity Neuropeptide Binding Peptidylamidoglycolate Lyase Activity Peptidylglycine Monooxygenase Activity Fatty Acid Primary Amide Biosynthetic Process Sulfite Oxidase Activity Symbiont-containing Vacuole Protein-N-terminal Glutamine Amidohydrolase Activity Glycerate Kinase Activity	Regulation Of System Process Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Transport Regulation Of Heart Contraction Regulation Of Blood Circulation Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Translational Initiation Response To Peptide Hormone Glucagon-like Peptide 1 Receptor Activity Negative Regulation Of Protein Glutathionylation Positive Regulation Of Oxytocin Production Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Neutrophil Mediated Killing Of Fungus Response To Melanocyte-stimulating Hormone Positive Regulation Of Dense Core Granule Biogenesis Protein Serine Kinase Activity Protein Phosphorylation Histone H3T6 Kinase Activity Phosphorylation Trans-Golgi Network Transport Vesicle Membrane Glucagon Receptor Activity Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Angiotensin-activated Signaling Pathway Regulation Of Translation Alphav-beta3 Integrin-PKCalpha Complex Protein Serine/threonine Kinase Activity Regulation Of Translational Initiation TSC1-TSC2 Complex Intracellular Signal Transduction Regulation Of Cell Cycle Cellular Pigmentation Type 1 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Positive Regulation Of Killing Of Cells Of Another Organism Type 3 Melanocortin Receptor Binding Protein Kinase C Signaling Transmembrane Transporter Binding Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Response To Psychosocial Stress Regulation Of Angiotensin-activated Signaling Pathway Protein Kinase Activity Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Signal Transduction Vesicle-mediated Transport Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane