TERF2IP and H2AC16

Number of citations: 82 (PubMedID 21044950)
Data Source: BioGRID (two hybrid)

		TERF2IP	H2AC16
Name		TERF2 interacting protein	H2A clustered histone 16
Structure
GO Annotations	Cellular Component	Nuclear Chromosome Chromosome, Telomeric Region Nuclear Telomere Cap Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Cytoplasm Nuclear Body Shelterin Complex	Nucleosome Nucleus Chromosome Extracellular Exosome
	Molecular Function	Protein Binding Phosphatase Binding Telomeric DNA Binding G-rich Strand Telomeric DNA Binding	DNA Binding Protein Binding Enzyme Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity
	Biological Process	Telomere Maintenance Negative Regulation Of Protein Phosphorylation Regulation Of DNA-templated Transcription Telomere Maintenance Via Telomerase Regulation Of Double-strand Break Repair Via Homologous Recombination Telomere Maintenance Via Telomere Lengthening Telomere Capping Protection From Non-homologous End Joining At Telomere Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Intracellular Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of DNA Recombination At Telomere Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Localization To Chromosome, Telomeric Region Positive Regulation Of Non-canonical NF-kappaB Signal Transduction	Heterochromatin Formation
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere	HDACs deacetylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines UCH proteinases Ub-specific processing proteases Metalloprotease DUBs HCMV Early Events HCMV Late Events
GWAS		Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Smoking status (ever vs never smokers) ( 30643258 ) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Weight ( 34074324 )	No GWAS studies recorded
Interacting Genes		122 interacting genes: ADA AIMP2 AK1 AKR1A1 AKR1B10 AKR7A3 AKT1 ANXA5 ANXA8L1 AP2B1 APEX1 ARPP21 BABAM1 BANP BCL7B C1orf174 CALML3 CHMP2B COTL1 CPNE2 CPNE3 CRK CRYBB1 CRYGS CTBP1 DBNL DDX23 DDX24 DDX39A DNMT3A DPP3 ENAH EPAS1 EPS8L1 ETS2 FABP2 GAGE5 GAMT GNMT H1-1 H2AC16 H4C2 HAAO HAGH HDGFL3 HMGB1 HMGB3 HMGN3 HMGN4 HNRNPK IDO1 IL1RN LANCL2 LGALSL MAGOHB MCM2 MDH1 MPG MRTO4 MT1X MT3 NAIF1 NASP NOL3 NPSR1 NUDT14 NUDT18 NXNL1 OCM2 OGFR PABIR1 PACSIN2 PACSIN3 PAFAH1B3 PCNP PCP4 PEA15 PGLS PGM1 PIAS1 PML PNMT PPP1R2 PPP6R3 PRDX6 PRX PTEN PTMA RABIF RAD50 RASSF5 RBBP9 RECQL4 RGMA RIF1 RPAP1 RPP25 S100P SBDS SCLY SCRN2 SET SNCG SP100 TALDO1 TBC1D10A TBCA TERF2 TMSB10 TMSB4Y TOR1AIP1 TSSC4 TWF2 UCHL1 VGLL4 WDR5 WIPI2 XAGE2 XPO1 XRCC5 ZNF146 ZNF414	5 interacting genes: BRD7 CRP GADD45A SAP30 TERF2IP
Entrez ID		54386	8332
HPRD ID		05452	09103
Ensembl ID		ENSG00000166848	ENSG00000276903
Uniprot IDs		Q9NYB0	A4FTV9 P0C0S8
PDB IDs		1FEX 3K6G 4RQI 7OZ0 8RD4	4QYL 5KGF 6R0C 6RNY 6X59 6X5A 6XJD 7BG9 7E8D 7JO9 7JOA 7TAN 7U50 7U51 7U52 7U53 7UV9 8ATF 8AV6 8GUI 8GUJ 8GUK 8OFF 8QZM 8VOB 8VWS 8VWT 8VWU 8VWV 9DWF 9DWG 9DWH 9DWI 9DWJ 9DWK 9DWL 9DWM
GO Terms Enriched among Interactors		Cytoplasm Protein Binding Cytosol Double-stranded Telomeric DNA Binding Nucleobase-containing Compound Metabolic Process Chromatin Organization Chromosome, Telomeric Region Telomere Organization Chromatin Remodeling Protein Domain Specific Binding Nucleus Telomere Maintenance Nucleoplasm Energy Reserve Metabolic Process Chromosome Organization Glycogen Metabolic Process Alcohol Dehydrogenase (NADP+) Activity Cellular Detoxification Of Aldehyde Extracellular Exosome Telomere Maintenance In Response To DNA Damage Myelin Maintenance Negative Regulation Of T-circle Formation Polysaccharide Metabolic Process Nucleic Acid Metabolic Process Nicotinamide Nucleotide Metabolic Process Maintenance Of Protein Localization In Organelle DNA Metabolic Process Plasma Membrane Organization Quinolinate Biosynthetic Process Allyl-alcohol Dehydrogenase Activity DNA Recombination Helicase Activity Regulation Of Growth Generation Of Precursor Metabolites And Energy Calcium-dependent Phospholipid Binding Negative Regulation Of DNA Metabolic Process Cadherin Binding Regulation Of Cellular Response To Stress Quinolinate Metabolic Process Mre11 Complex Negative Regulation Of Cellular Component Organization Carbohydrate Metabolic Process Regulation Of Cell Growth Actin Monomer Binding Positive Regulation Of Proteolysis Maintenance Of Protein Location In Cell RNA-templated DNA Biosynthetic Process	Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Protein Phosphorylation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Phosphate Metabolic Process Negative Regulation Of Phosphorylation Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Regulation Of Double-strand Break Repair Negative Regulation Of DNA Recombination At Telomere Negative Regulation Of Developmental Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Choline Binding Regulation Of Developmental Process Negative Regulation Of Peptidyl-serine Phosphorylation Transcription Corepressor Activity Histone H3K14ac Reader Activity Regulation Of Chromosome Organization Regulation Of DNA Repair Protection From Non-homologous End Joining At Telomere Shelterin Complex Negative Regulation Of Macromolecule Metabolic Process Complement Component C1q Complex Binding Positive Regulation Of DNA Metabolic Process Nuclear Telomere Cap Complex Virion Binding Negative Regulation Of Metabolic Process G-rich Strand Telomeric DNA Binding Regulation Of Multicellular Organismal Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of DNA-templated Transcription Negative Regulation Of Cell Motility Negative Regulation Of Cell Migration Negative Regulation Of RNA Biosynthetic Process Protein Localization To Chromosome, Telomeric Region Telomere Capping Telomere Maintenance In Response To DNA Damage Low-density Lipoprotein Particle Binding Opsonization Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of Protein Phosphorylation Negative Regulation Of Locomotion Regulation Of RNA Biosynthetic Process RSC-type Complex Positive Regulation Of Superoxide Anion Generation Regulation Of Phosphorylation Negative Regulation Of Lipid Storage