TERF2IP and AKR1B10

Number of citations: 82 (PubMedID 21044950)
Data Source: BioGRID (two hybrid)

		TERF2IP	AKR1B10
Name		TERF2 interacting protein	aldo-keto reductase family 1 member B10
Structure
GO Annotations	Cellular Component	Nuclear Chromosome Chromosome, Telomeric Region Nuclear Telomere Cap Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Cytoplasm Nuclear Body Shelterin Complex	Extracellular Region Mitochondrion Lysosome Cytosol
	Molecular Function	Protein Binding Phosphatase Binding Telomeric DNA Binding G-rich Strand Telomeric DNA Binding	Retinal Dehydrogenase (NAD+) Activity Aldose Reductase (NADPH) Activity Protein Binding Alcohol Dehydrogenase (NADP+) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Geranylgeranyl Reductase Activity Allyl-alcohol Dehydrogenase Activity Indanol Dehydrogenase Activity All-trans-retinol Dehydrogenase (NADP+) Activity
	Biological Process	Telomere Maintenance Negative Regulation Of Protein Phosphorylation Regulation Of DNA-templated Transcription Telomere Maintenance Via Telomerase Regulation Of Double-strand Break Repair Via Homologous Recombination Telomere Maintenance Via Telomere Lengthening Telomere Capping Protection From Non-homologous End Joining At Telomere Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Intracellular Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of DNA Recombination At Telomere Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Localization To Chromosome, Telomeric Region Positive Regulation Of Non-canonical NF-kappaB Signal Transduction	Retinoid Metabolic Process Lipid Metabolic Process Farnesol Catabolic Process Retinol Metabolic Process Daunorubicin Metabolic Process Doxorubicin Metabolic Process Cellular Detoxification Of Aldehyde
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere	Retinoid metabolism and transport
Drugs		None	Sulindac Fidarestat Tolrestat Nicotinamide adenine dinucleotide phosphate Exisulind Zopolrestat
GWAS		Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Smoking status (ever vs never smokers) ( 30643258 ) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Weight ( 34074324 )	Diastolic blood pressure ( 30224653 ) Familial lung adenocarcinoma ( 29924316 ) Medication use (agents acting on the renin-angiotensin system) ( 31015401 ) White matter growth ( 29682794 )
Novel Interactors		1 novel interactors: GPAA1	None recorded
Interacting Genes		122 interacting genes: ADA AIMP2 AK1 AKR1A1 AKR1B10 AKR7A3 AKT1 ANXA5 ANXA8L1 AP2B1 APEX1 ARPP21 BABAM1 BANP BCL7B C1orf174 CALML3 CHMP2B COTL1 CPNE2 CPNE3 CRK CRYBB1 CRYGS CTBP1 DBNL DDX23 DDX24 DDX39A DNMT3A DPP3 ENAH EPAS1 EPS8L1 ETS2 FABP2 GAGE5 GAMT GNMT H1-1 H2AC16 H4C2 HAAO HAGH HDGFL3 HMGB1 HMGB3 HMGN3 HMGN4 HNRNPK IDO1 IL1RN LANCL2 LGALSL MAGOHB MCM2 MDH1 MPG MRTO4 MT1X MT3 NAIF1 NASP NOL3 NPSR1 NUDT14 NUDT18 NXNL1 OCM2 OGFR PABIR1 PACSIN2 PACSIN3 PAFAH1B3 PCNP PCP4 PEA15 PGLS PGM1 PIAS1 PML PNMT PPP1R2 PPP6R3 PRDX6 PRX PTEN PTMA RABIF RAD50 RASSF5 RBBP9 RECQL4 RGMA RIF1 RPAP1 RPP25 S100P SBDS SCLY SCRN2 SET SNCG SP100 TALDO1 TBC1D10A TBCA TERF2 TMSB10 TMSB4Y TOR1AIP1 TSSC4 TWF2 UCHL1 VGLL4 WDR5 WIPI2 XAGE2 XPO1 XRCC5 ZNF146 ZNF414	1 interacting genes: TERF2IP
Entrez ID		54386	57016
HPRD ID		05452	05271
Ensembl ID		ENSG00000166848	ENSG00000198074
Uniprot IDs		Q9NYB0	O60218
PDB IDs		1FEX 3K6G 4RQI 7OZ0 8RD4	1ZUA 4GA8 4GAB 4GQ0 4GQG 4I5X 4ICC 4JIH 4JII 4WEV 4XZL 4XZM 4XZN 5LIK 5LIU 5LIW 5LIX 5LIY 5M2F 5Y7N
GO Terms Enriched among Interactors		Cytoplasm Protein Binding Cytosol Double-stranded Telomeric DNA Binding Nucleobase-containing Compound Metabolic Process Chromatin Organization Chromosome, Telomeric Region Telomere Organization Chromatin Remodeling Protein Domain Specific Binding Nucleus Telomere Maintenance Nucleoplasm Energy Reserve Metabolic Process Chromosome Organization Glycogen Metabolic Process Alcohol Dehydrogenase (NADP+) Activity Cellular Detoxification Of Aldehyde Extracellular Exosome Telomere Maintenance In Response To DNA Damage Myelin Maintenance Negative Regulation Of T-circle Formation Polysaccharide Metabolic Process Nucleic Acid Metabolic Process Nicotinamide Nucleotide Metabolic Process Maintenance Of Protein Localization In Organelle DNA Metabolic Process Plasma Membrane Organization Quinolinate Biosynthetic Process Allyl-alcohol Dehydrogenase Activity DNA Recombination Helicase Activity Regulation Of Growth Generation Of Precursor Metabolites And Energy Calcium-dependent Phospholipid Binding Negative Regulation Of DNA Metabolic Process Cadherin Binding Regulation Of Cellular Response To Stress Quinolinate Metabolic Process Mre11 Complex Negative Regulation Of Cellular Component Organization Carbohydrate Metabolic Process Regulation Of Cell Growth Actin Monomer Binding Positive Regulation Of Proteolysis Maintenance Of Protein Location In Cell RNA-templated DNA Biosynthetic Process	Negative Regulation Of DNA Recombination At Telomere Protein Localization To Chromosome, Telomeric Region Nuclear Telomere Cap Complex Protection From Non-homologous End Joining At Telomere Shelterin Complex Telomere Capping G-rich Strand Telomeric DNA Binding Telomere Maintenance In Response To DNA Damage Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Nuclear Chromosome RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Phosphatase Binding Negative Regulation Of DNA Recombination Male Germ Cell Nucleus Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Telomere Maintenance Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Chromosome Organization Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Protein Phosphorylation DNA Biosynthetic Process Telomere Maintenance Protein Localization To Chromosome Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Chromosome Organization Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Telomere Maintenance Negative Regulation Of Phosphorylation Telomere Organization Negative Regulation Of DNA Metabolic Process Regulation Of DNA Recombination Regulation Of Double-strand Break Repair Negative Regulation Of Phosphate Metabolic Process Chromosome, Telomeric Region Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of DNA Repair Regulation Of Chromosome Organization Positive Regulation Of DNA Metabolic Process