TERF2IP and IDO1

Number of citations: 82 (PubMedID 21044950)
Data Source: BioGRID (two hybrid)

		TERF2IP	IDO1
Name		TERF2 interacting protein	indoleamine 2,3-dioxygenase 1
Structure
GO Annotations	Cellular Component	Nuclear Chromosome Chromosome, Telomeric Region Nuclear Telomere Cap Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Cytoplasm Nuclear Body Shelterin Complex	Cytoplasm Cytosol Smooth Muscle Contractile Fiber Stereocilium Bundle
	Molecular Function	Protein Binding Phosphatase Binding Telomeric DNA Binding G-rich Strand Telomeric DNA Binding	Tryptophan 2,3-dioxygenase Activity Electron Transfer Activity Oxidoreductase Activity Heme Binding Indoleamine 2,3-dioxygenase Activity Metal Ion Binding Dioxygenase Activity
	Biological Process	Telomere Maintenance Negative Regulation Of Protein Phosphorylation Regulation Of DNA-templated Transcription Telomere Maintenance Via Telomerase Regulation Of Double-strand Break Repair Via Homologous Recombination Telomere Maintenance Via Telomere Lengthening Telomere Capping Protection From Non-homologous End Joining At Telomere Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Intracellular Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of DNA Recombination At Telomere Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Localization To Chromosome, Telomeric Region Positive Regulation Of Non-canonical NF-kappaB Signal Transduction	Immune System Process Positive Regulation Of T Cell Tolerance Induction Positive Regulation Of Chronic Inflammatory Response Positive Regulation Of Type 2 Immune Response L-tryptophan Catabolic Process Inflammatory Response Female Pregnancy L-tryptophan Catabolic Process To Kynurenine Quinolinate Biosynthetic Process Response To Lipopolysaccharide Negative Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Multicellular Organismal Response To Stress Kynurenic Acid Biosynthetic Process 'de Novo' NAD+ Biosynthetic Process From L-tryptophan Swimming Behavior T Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Apoptotic Process Regulation Of Activated T Cell Proliferation Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of T Cell Apoptotic Process
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere	Tryptophan catabolism
Drugs		None	Nitric Oxide Cannabidiol Medical Cannabis Nabiximols
GWAS		Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Smoking status (ever vs never smokers) ( 30643258 ) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Weight ( 34074324 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: GPAA1	6 novel interactors: ADRB3 DCTN6 DUSP4 RBPMS SFRP1 SLC20A2
Interacting Genes		122 interacting genes: ADA AIMP2 AK1 AKR1A1 AKR1B10 AKR7A3 AKT1 ANXA5 ANXA8L1 AP2B1 APEX1 ARPP21 BABAM1 BANP BCL7B C1orf174 CALML3 CHMP2B COTL1 CPNE2 CPNE3 CRK CRYBB1 CRYGS CTBP1 DBNL DDX23 DDX24 DDX39A DNMT3A DPP3 ENAH EPAS1 EPS8L1 ETS2 FABP2 GAGE5 GAMT GNMT H1-1 H2AC16 H4C2 HAAO HAGH HDGFL3 HMGB1 HMGB3 HMGN3 HMGN4 HNRNPK IDO1 IL1RN LANCL2 LGALSL MAGOHB MCM2 MDH1 MPG MRTO4 MT1X MT3 NAIF1 NASP NOL3 NPSR1 NUDT14 NUDT18 NXNL1 OCM2 OGFR PABIR1 PACSIN2 PACSIN3 PAFAH1B3 PCNP PCP4 PEA15 PGLS PGM1 PIAS1 PML PNMT PPP1R2 PPP6R3 PRDX6 PRX PTEN PTMA RABIF RAD50 RASSF5 RBBP9 RECQL4 RGMA RIF1 RPAP1 RPP25 S100P SBDS SCLY SCRN2 SET SNCG SP100 TALDO1 TBC1D10A TBCA TERF2 TMSB10 TMSB4Y TOR1AIP1 TSSC4 TWF2 UCHL1 VGLL4 WDR5 WIPI2 XAGE2 XPO1 XRCC5 ZNF146 ZNF414	5 interacting genes: APP DDX24 FBXL17 PPP1R16A TERF2IP
Entrez ID		54386	3620
HPRD ID		05452	00935
Ensembl ID		ENSG00000166848	ENSG00000131203
Uniprot IDs		Q9NYB0	A0A348GSI3 P14902
PDB IDs		1FEX 3K6G 4RQI 7OZ0 8RD4	2D0T 2D0U 4PK5 4PK6 4U72 4U74 5EK2 5EK3 5EK4 5ETW 5WHR 5WMU 5WMV 5WMW 5WMX 5WN8 5XE1 6AZU 6AZV 6AZW 6CXU 6CXV 6DPQ 6DPR 6E35 6E40 6E41 6E42 6E43 6E44 6E45 6E46 6F0A 6KOF 6KPS 6KW7 6MQ6 6O3I 6PU7 6PZ1 6R63 6UBP 6V52 6WJY 6WPE 6X5Y 7A62 7AH4 7AH5 7AH6 7B1O 7E0O 7E0P 7E0Q 7E0S 7E0T 7E0U 7M63 7M7D 7NGE 7P0N 7P0R 7RRB 7RRC 7RRD 7YXT 7Z2L 7ZV3 8ABX 8FUR 8I7L 8U5I 9ESB 9ESC 9ESE 9ESG
GO Terms Enriched among Interactors		Cytoplasm Protein Binding Cytosol Double-stranded Telomeric DNA Binding Nucleobase-containing Compound Metabolic Process Chromatin Organization Chromosome, Telomeric Region Telomere Organization Chromatin Remodeling Protein Domain Specific Binding Nucleus Telomere Maintenance Nucleoplasm Energy Reserve Metabolic Process Chromosome Organization Glycogen Metabolic Process Alcohol Dehydrogenase (NADP+) Activity Cellular Detoxification Of Aldehyde Extracellular Exosome Telomere Maintenance In Response To DNA Damage Myelin Maintenance Negative Regulation Of T-circle Formation Polysaccharide Metabolic Process Nucleic Acid Metabolic Process Nicotinamide Nucleotide Metabolic Process Maintenance Of Protein Localization In Organelle DNA Metabolic Process Plasma Membrane Organization Quinolinate Biosynthetic Process Allyl-alcohol Dehydrogenase Activity DNA Recombination Helicase Activity Regulation Of Growth Generation Of Precursor Metabolites And Energy Calcium-dependent Phospholipid Binding Negative Regulation Of DNA Metabolic Process Cadherin Binding Regulation Of Cellular Response To Stress Quinolinate Metabolic Process Mre11 Complex Negative Regulation Of Cellular Component Organization Carbohydrate Metabolic Process Regulation Of Cell Growth Actin Monomer Binding Positive Regulation Of Proteolysis Maintenance Of Protein Location In Cell RNA-templated DNA Biosynthetic Process	None