TERF2IP and WIPI2

Number of citations: 82 (PubMedID 21044950)
Data Source: BioGRID (two hybrid)

		TERF2IP	WIPI2
Name		TERF2 interacting protein	WD repeat domain, phosphoinositide interacting 2
Structure
GO Annotations	Cellular Component	Nuclear Chromosome Chromosome, Telomeric Region Nuclear Telomere Cap Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Cytoplasm Nuclear Body Shelterin Complex	Phagophore Assembly Site Nucleoplasm Autophagosome Cytosol Membrane Protein-containing Complex Phagophore Assembly Site Membrane
	Molecular Function	Protein Binding Phosphatase Binding Telomeric DNA Binding G-rich Strand Telomeric DNA Binding	Protein Binding Lipid Binding Phosphatidylinositol-5-phosphate Binding Protein-macromolecule Adaptor Activity Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Telomere Maintenance Negative Regulation Of Protein Phosphorylation Regulation Of DNA-templated Transcription Telomere Maintenance Via Telomerase Regulation Of Double-strand Break Repair Via Homologous Recombination Telomere Maintenance Via Telomere Lengthening Telomere Capping Protection From Non-homologous End Joining At Telomere Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Intracellular Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of DNA Recombination At Telomere Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Localization To Chromosome, Telomeric Region Positive Regulation Of Non-canonical NF-kappaB Signal Transduction	Autophagosome Assembly Autophagy Of Mitochondrion Pexophagy Autophagy Response To Stress Cellular Response To Starvation Protein Localization To Phagophore Assembly Site Nucleophagy Glycophagy Autophagosome Maturation
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere	Macroautophagy
GWAS		Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Smoking status (ever vs never smokers) ( 30643258 ) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Weight ( 34074324 )	Bone mineral density x blood lead interaction in current smokers (1df test) ( 29518117 ) Bone mineral density x blood lead interaction in current smokers (2df test) ( 29518117 ) High light scatter reticulocyte count ( 32888494 ) Immature fraction of reticulocytes ( 27863252 32888494 ) Mean corpuscular hemoglobin ( 27863252 32888494 ) Mean corpuscular hemoglobin concentration ( 32888494 ) Mean corpuscular volume ( 27863252 32888494 ) Red blood cell count ( 32888494 )
Interacting Genes		122 interacting genes: ADA AIMP2 AK1 AKR1A1 AKR1B10 AKR7A3 AKT1 ANXA5 ANXA8L1 AP2B1 APEX1 ARPP21 BABAM1 BANP BCL7B C1orf174 CALML3 CHMP2B COTL1 CPNE2 CPNE3 CRK CRYBB1 CRYGS CTBP1 DBNL DDX23 DDX24 DDX39A DNMT3A DPP3 ENAH EPAS1 EPS8L1 ETS2 FABP2 GAGE5 GAMT GNMT H1-1 H2AC16 H4C2 HAAO HAGH HDGFL3 HMGB1 HMGB3 HMGN3 HMGN4 HNRNPK IDO1 IL1RN LANCL2 LGALSL MAGOHB MCM2 MDH1 MPG MRTO4 MT1X MT3 NAIF1 NASP NOL3 NPSR1 NUDT14 NUDT18 NXNL1 OCM2 OGFR PABIR1 PACSIN2 PACSIN3 PAFAH1B3 PCNP PCP4 PEA15 PGLS PGM1 PIAS1 PML PNMT PPP1R2 PPP6R3 PRDX6 PRX PTEN PTMA RABIF RAD50 RASSF5 RBBP9 RECQL4 RGMA RIF1 RPAP1 RPP25 S100P SBDS SCLY SCRN2 SET SNCG SP100 TALDO1 TBC1D10A TBCA TERF2 TMSB10 TMSB4Y TOR1AIP1 TSSC4 TWF2 UCHL1 VGLL4 WDR5 WIPI2 XAGE2 XPO1 XRCC5 ZNF146 ZNF414	18 interacting genes: ARL6IP1 ATG16L1 COPS6 CRYAA DDB1 DGAT2L6 FKBP7 HUWE1 MRRF MTOR OPTN POT1 RABAC1 REEP6 RPTOR STRN4 SYP TERF2IP
Entrez ID		54386	26100
HPRD ID		05452	15679
Ensembl ID		ENSG00000166848	ENSG00000157954
Uniprot IDs		Q9NYB0	Q9Y4P8
PDB IDs		1FEX 3K6G 4RQI 7OZ0 8RD4	7F69 7MU2 7XFR
GO Terms Enriched among Interactors		Cytoplasm Protein Binding Cytosol Double-stranded Telomeric DNA Binding Nucleobase-containing Compound Metabolic Process Chromatin Organization Chromosome, Telomeric Region Telomere Organization Chromatin Remodeling Protein Domain Specific Binding Nucleus Telomere Maintenance Nucleoplasm Energy Reserve Metabolic Process Chromosome Organization Glycogen Metabolic Process Alcohol Dehydrogenase (NADP+) Activity Cellular Detoxification Of Aldehyde Extracellular Exosome Telomere Maintenance In Response To DNA Damage Myelin Maintenance Negative Regulation Of T-circle Formation Polysaccharide Metabolic Process Nucleic Acid Metabolic Process Nicotinamide Nucleotide Metabolic Process Maintenance Of Protein Localization In Organelle DNA Metabolic Process Plasma Membrane Organization Quinolinate Biosynthetic Process Allyl-alcohol Dehydrogenase Activity DNA Recombination Helicase Activity Regulation Of Growth Generation Of Precursor Metabolites And Energy Calcium-dependent Phospholipid Binding Negative Regulation Of DNA Metabolic Process Cadherin Binding Regulation Of Cellular Response To Stress Quinolinate Metabolic Process Mre11 Complex Negative Regulation Of Cellular Component Organization Carbohydrate Metabolic Process Regulation Of Cell Growth Actin Monomer Binding Positive Regulation Of Proteolysis Maintenance Of Protein Location In Cell RNA-templated DNA Biosynthetic Process	Organelle Organization Positive Regulation Of Catabolic Process Positive Regulation Of Pentose-phosphate Shunt TORC1 Complex Regulation Of Pentose-phosphate Shunt Shelterin Complex Regulation Of NADP Metabolic Process Positive Regulation Of Autophagy Regulation Of Autophagy Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Regulation Of Cellular Component Organization Protein-macromolecule Adaptor Activity Cellular Response To L-leucine Telomere Capping Response To L-leucine Autophagosome Assembly Positive Regulation Of Transcription By RNA Polymerase III Autophagosome Organization Serine/threonine Protein Kinase Complex Positive Regulation Of Glycolytic Process Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase III Telomeric DNA Binding Protein-containing Complex Binding Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Cell Growth Positive Regulation Of Small Molecule Metabolic Process Macroautophagy Regulation Of Cell Growth Chromosome, Telomeric Region Vacuole Organization Positive Regulation Of ATP Metabolic Process GTPase Binding Negative Regulation Of Telomere Maintenance DNA Damage Response Negative Regulation Of Intracellular Signal Transduction Regulation Of Macroautophagy Positive Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Vacuole-isolation Membrane Contact Site Negative Regulation Of Translational Initiation Cellular Response To Osmotic Stress Positive Regulation Of Translational Initiation Identical Protein Binding Regulation Of Glycolytic Process Cytoplasmic Vesicle