TERF2IP and COTL1

Number of citations: 82 (PubMedID 21044950)
Data Source: BioGRID (two hybrid)

		TERF2IP	COTL1
Name		TERF2 interacting protein	coactosin like F-actin binding protein 1
Structure
GO Annotations	Cellular Component	Nuclear Chromosome Chromosome, Telomeric Region Nuclear Telomere Cap Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Cytoplasm Nuclear Body Shelterin Complex	Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Actin Filament Site Of Polarized Growth Cortical Actin Cytoskeleton Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding Phosphatase Binding Telomeric DNA Binding G-rich Strand Telomeric DNA Binding	Actin Binding Protein Binding Enzyme Binding Actin Filament Binding
	Biological Process	Telomere Maintenance Negative Regulation Of Protein Phosphorylation Regulation Of DNA-templated Transcription Telomere Maintenance Via Telomerase Regulation Of Double-strand Break Repair Via Homologous Recombination Telomere Maintenance Via Telomere Lengthening Telomere Capping Protection From Non-homologous End Joining At Telomere Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Intracellular Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of DNA Recombination At Telomere Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Localization To Chromosome, Telomeric Region Positive Regulation Of Non-canonical NF-kappaB Signal Transduction	Regulation Of Actin Filament Polymerization Defense Response To Fungus
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere	Neutrophil degranulation
GWAS		Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Smoking status (ever vs never smokers) ( 30643258 ) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Weight ( 34074324 )	Carotid intima media thickness x smoking interaction ( 32117412 ) Cleft lip with or without cleft palate (maternal periconceptional vitamin use interaction) ( 29535761 ) Cocaine dependence ( 31212010 ) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383 ) Heel bone mineral density ( 30598549 ) Macular thickness ( 30535121 )
Interacting Genes		122 interacting genes: ADA AIMP2 AK1 AKR1A1 AKR1B10 AKR7A3 AKT1 ANXA5 ANXA8L1 AP2B1 APEX1 ARPP21 BABAM1 BANP BCL7B C1orf174 CALML3 CHMP2B COTL1 CPNE2 CPNE3 CRK CRYBB1 CRYGS CTBP1 DBNL DDX23 DDX24 DDX39A DNMT3A DPP3 ENAH EPAS1 EPS8L1 ETS2 FABP2 GAGE5 GAMT GNMT H1-1 H2AC16 H4C2 HAAO HAGH HDGFL3 HMGB1 HMGB3 HMGN3 HMGN4 HNRNPK IDO1 IL1RN LANCL2 LGALSL MAGOHB MCM2 MDH1 MPG MRTO4 MT1X MT3 NAIF1 NASP NOL3 NPSR1 NUDT14 NUDT18 NXNL1 OCM2 OGFR PABIR1 PACSIN2 PACSIN3 PAFAH1B3 PCNP PCP4 PEA15 PGLS PGM1 PIAS1 PML PNMT PPP1R2 PPP6R3 PRDX6 PRX PTEN PTMA RABIF RAD50 RASSF5 RBBP9 RECQL4 RGMA RIF1 RPAP1 RPP25 S100P SBDS SCLY SCRN2 SET SNCG SP100 TALDO1 TBC1D10A TBCA TERF2 TMSB10 TMSB4Y TOR1AIP1 TSSC4 TWF2 UCHL1 VGLL4 WDR5 WIPI2 XAGE2 XPO1 XRCC5 ZNF146 ZNF414	6 interacting genes: ACTA1 ACTB ACTG1 ALOX5 PDE6H TERF2IP
Entrez ID		54386	23406
HPRD ID		05452	09482
Ensembl ID		ENSG00000166848	ENSG00000103187
Uniprot IDs		Q9NYB0	A0A384MTY2 Q14019
PDB IDs		1FEX 3K6G 4RQI 7OZ0 8RD4	1T2L 1T3X 1T3Y 1TMW 1VFQ 1WNJ
GO Terms Enriched among Interactors		Cytoplasm Protein Binding Cytosol Double-stranded Telomeric DNA Binding Nucleobase-containing Compound Metabolic Process Chromatin Organization Chromosome, Telomeric Region Telomere Organization Chromatin Remodeling Protein Domain Specific Binding Nucleus Telomere Maintenance Nucleoplasm Energy Reserve Metabolic Process Chromosome Organization Glycogen Metabolic Process Alcohol Dehydrogenase (NADP+) Activity Cellular Detoxification Of Aldehyde Extracellular Exosome Telomere Maintenance In Response To DNA Damage Myelin Maintenance Negative Regulation Of T-circle Formation Polysaccharide Metabolic Process Nucleic Acid Metabolic Process Nicotinamide Nucleotide Metabolic Process Maintenance Of Protein Localization In Organelle DNA Metabolic Process Plasma Membrane Organization Quinolinate Biosynthetic Process Allyl-alcohol Dehydrogenase Activity DNA Recombination Helicase Activity Regulation Of Growth Generation Of Precursor Metabolites And Energy Calcium-dependent Phospholipid Binding Negative Regulation Of DNA Metabolic Process Cadherin Binding Regulation Of Cellular Response To Stress Quinolinate Metabolic Process Mre11 Complex Negative Regulation Of Cellular Component Organization Carbohydrate Metabolic Process Regulation Of Cell Growth Actin Monomer Binding Positive Regulation Of Proteolysis Maintenance Of Protein Location In Cell RNA-templated DNA Biosynthetic Process	Regulation Of Transepithelial Transport Dense Body Morphogenesis Of A Polarized Epithelium Structural Constituent Of Postsynaptic Actin Cytoskeleton Actin Filament Structural Constituent Of Cytoskeleton Blood Microparticle Postsynaptic Actin Cytoskeleton Organization Protein Localization To Cell-cell Junction Calyx Of Held Postsynaptic Cytoskeleton Organization Regulation Of Synaptic Vesicle Endocytosis NuA4 Histone Acetyltransferase Complex Apical Junction Complex Regulation Of Synaptic Vesicle Recycling Maintenance Of Blood-brain Barrier Hydrolase Activity Actin Cytoskeleton Platelet Aggregation Morphogenesis Of An Epithelium Homotypic Cell-cell Adhesion Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Basal Body Patch Leukotriene A4 Biosynthetic Process Arachidonate 5-lipoxygenase Activity Tissue Morphogenesis Protein Localization To Cell Junction Regulation Of Double-strand Break Repair Via Homologous Recombination Schaffer Collateral - CA1 Synapse Regulation Of Norepinephrine Uptake Leukotriene A4 Metabolic Process Leukotriene Production Involved In Inflammatory Response Arachidonate 8(S)-lipoxygenase Activity Negative Regulation Of DNA Recombination At Telomere Regulation Of Cellular Response To Stress Cell-cell Junction Assembly Nuclear Matrix Transporter Regulator Activity Lipoxin Biosynthetic Process Arachidonate 12(S)-lipoxygenase Activity Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Regulation Of DNA Recombination Regulation Of Wound Healing Cytoskeleton Extracellular Space Regulation Of Double-strand Break Repair Arachidonate Metabolite Production Involved In Inflammatory Response Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen Axonogenesis