POLA1 and GINS4

Number of citations: 58 (PubMedID 21705323)
Data Source: BioGRID (pull down)

		POLA1	GINS4
Name		DNA polymerase alpha 1, catalytic subunit	GINS complex subunit 4
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nuclear Envelope Nucleoplasm Alpha DNA Polymerase:primase Complex Nucleolus Cytoplasm Cytosol Nuclear Matrix	GINS Complex Nucleus Nucleoplasm Chromosome Cytoplasm CMG Complex
	Molecular Function	Nucleotide Binding Nucleic Acid Binding DNA Binding Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity Protein Kinase Binding DNA Polymerase Activity Metal Ion Binding	Protein Binding
	Biological Process	DNA Synthesis Involved In DNA Repair DNA Replication DNA-templated DNA Replication DNA Replication, Synthesis Of Primer DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Leading Strand Elongation Lagging Strand Elongation DNA Repair Nucleotide-excision Repair Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Type I Interferon Production Mitotic DNA Replication Initiation DNA Synthesis Involved In UV-damage Excision Repair	Double-strand Break Repair Via Break-induced Replication Inner Cell Mass Cell Proliferation DNA Replication DNA-templated DNA Replication
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand G1/S-Specific Transcription Defective pyroptosis	Unwinding of DNA Unwinding of DNA
Drugs		Cladribine Clofarabine Fludarabine Nelarabine	None
GWAS		Mean platelet volume ( 32888494 ) Platelet count ( 32888494 )	No GWAS studies recorded
Interacting Genes		18 interacting genes: CDC45 CDK1 CDK2 CDK2AP1 GINS4 HELB PARP1 POLA2 POLE PRIM2 RAD51 RB1 RBMS1 SERPINA3 SMC1A SUMO2 TP53 XRCC5	12 interacting genes: - BIN3 CTNNBIP1 DMAP1 GINS2 KIF16B LHX8 PBX4 POLA1 POLD1 POLE PPP1R13B
Entrez ID		5422	84296
HPRD ID		02416	11583
Ensembl ID		ENSG00000101868	ENSG00000147536
Uniprot IDs		A6NMQ1 P09884	Q9BRT9
PDB IDs		1K0P 1K18 1N5G 4Q5V 4QCL 4Y97 5EXR 5IUD 6AS7 7N2M 7OPL 7U5C 8B9D 8D0B 8D0K 8D96 8D9D 8QJ7 8VY3 9C8V 9MJ5	2E9X 2EHO 2Q9Q 6XTX 6XTY 7PFO 7PLO 8B9D 8OK2
GO Terms Enriched among Interactors		DNA Metabolic Process DNA Replication DNA Repair Nucleic Acid Metabolic Process DNA-templated DNA Replication DNA Damage Response Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Biosynthetic Process Chromosome Organization DNA Replication, Synthesis Of Primer Macromolecule Metabolic Process Chromosome, Telomeric Region Chromatin Binding Regulation Of DNA Metabolic Process Cellular Response To Stress Nucleoplasm Double-strand Break Repair Regulation Of Chromosome Organization Response To Gamma Radiation Macromolecule Biosynthetic Process Negative Regulation Of DNA Metabolic Process Recombinational Repair Chromosome Cellular Response To Radiation DNA Binding G1/S Transition Of Mitotic Cell Cycle Regulation Of Double-strand Break Repair Via Homologous Recombination Cell Cycle G1/S Phase Transition Cyclin-dependent Protein Kinase Activity DNA Replication Proofreading DNA Biosynthetic Process DNA Replication Initiation Cellular Response To Gamma Radiation Site Of Double-strand Break Telomere Maintenance Nucleus Negative Regulation Of Cell Cycle Phase Transition Protein Localization To Chromosome PML Body DNA Recombination Alpha DNA Polymerase:primase Complex Glial Cell Apoptotic Process Response To Radiation Regulation Of Cell Cycle Phase Transition Telomere Organization Histone Kinase Activity Nucleotide-excision Repair, DNA Gap Filling Negative Regulation Of Cell Cycle Process 4 Iron, 4 Sulfur Cluster Binding Double-strand Break Repair Via Homologous Recombination	DNA Polymerase Activity DNA-directed DNA Polymerase Activity DNA Replication Proofreading DNA Synthesis Involved In DNA Repair Leading Strand Elongation DNA Replication DNA-templated DNA Replication Nucleotide-excision Repair, DNA Gap Filling DNA Repair DNA Strand Elongation Involved In DNA Replication Nucleotidyltransferase Activity DNA Biosynthetic Process Base-excision Repair, Gap-filling DNA Strand Elongation DNA Metabolic Process DNA Damage Response 4 Iron, 4 Sulfur Cluster Binding Actin Cortical Patch Localization Regulation Of Vascular Permeability Involved In Acute Inflammatory Response Iron-sulfur Cluster Binding Beta-catenin-ICAT Complex Indoleamine 2,3-dioxygenase Activity Lagging Strand Elongation DNA Synthesis Involved In UV-damage Excision Repair Unidimensional Cell Growth Tryptophan 2,3-dioxygenase Activity Mitotic DNA Replication Initiation Nucleobase-containing Compound Biosynthetic Process Alpha DNA Polymerase:primase Complex Error-free Translesion Synthesis Delta DNA Polymerase Complex Epsilon DNA Polymerase Complex Single-stranded DNA 3'-5' DNA Exonuclease Activity GINS Complex Myoblast Migration Involved In Skeletal Muscle Regeneration Response To Ethanol L-tryptophan Catabolic Process To Kynurenine Cellular Response To Stress DNA Replication, Synthesis Of Primer Nucleotide-excision Repair Complex Negative Regulation Of DNA-templated Transcription Initiation Negative Regulation Of Transcription Initiation By RNA Polymerase II