PODXL and SELL

Number of citations: 64 (PubMedID 9625756)
Data Source: HPRD (in vivo)

		PODXL	SELL
Name		podocalyxin like	selectin L
Structure		No pdb structure
GO Annotations	Cellular Component	Ruffle Extracellular Space Nucleolus Cytoplasm Endoplasmic Reticulum Plasma Membrane Microvillus Membrane Apical Plasma Membrane Lamellipodium Filopodium Microvillus Membrane Centriolar Satellite Slit Diaphragm Cell Projection Membrane Raft Extracellular Exosome	Extracellular Space Plasma Membrane External Side Of Plasma Membrane Membrane Secretory Granule Membrane
	Molecular Function	Protein Binding	Protease Binding Calcium Ion Binding Protein Binding Heparin Binding Carbohydrate Binding Sialic Acid Binding Glycosphingolipid Binding Metal Ion Binding Oligosaccharide Binding
	Biological Process	Cell Adhesion Negative Regulation Of Cell Adhesion Cell Migration Regulation Of Cell-cell Adhesion Negative Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Migration Regulation Of Microvillus Assembly Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Podocyte Development Epithelial Tube Formation	Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Response To Cytokine Leukocyte Migration Leukocyte Tethering Or Rolling Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules
Pathways		None	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Neutrophil degranulation
GWAS		Alcohol dependence symptom count ( 27151647 ) Diastolic blood pressure ( 27841878 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Hypertension ( 28273873 ) Idiopathic dilated cardiomyopathy ( 29495422 ) Medication use (agents acting on the renin-angiotensin system) ( 31015401 ) Pulse pressure ( 30578418 ) Schizophrenia ( 25056061 ) Systolic blood pressure ( 27841878 30578418 )	Acne (severe) ( 24399259 ) Amyotrophic lateral sclerosis ( 19451621 ) Basophil percentage of white cells ( 32888494 ) Blood protein levels ( 30072576 ) Eosinophil percentage of white cells ( 32888494 ) Inflammatory bowel disease ( 26192919 ) L-selectin levels ( 25576479 ) Monocyte count ( 32888494 )
Interacting Genes		5 interacting genes: NHERF2 SELL SGTA SGTB UBQLN2	16 interacting genes: CD4 CFH EMCN EZR GRB2 MSN MUC7 PODXL PODXL2 PRKCA PRKCQ PRKG1 SELE SELPLG SLC30A2 VCAN
Entrez ID		5420	6402
HPRD ID		04025	07034
Ensembl ID		ENSG00000128567	ENSG00000188404
Uniprot IDs		O00592 Q96N83	P14151
PDB IDs		Not available	2LGF 3CFW 5VC1
GO Terms Enriched among Interactors		TRC Complex Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Molecular Adaptor Activity Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of Response To Endoplasmic Reticulum Stress Protein Targeting To Membrane Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Localization Within Membrane Positive Regulation Of Proteasomal Protein Catabolic Process Type 2 Metabotropic Glutamate Receptor Binding Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Type 3 Metabotropic Glutamate Receptor Binding BAT3 Complex Binding Identical Protein Binding Negative Regulation Of Clathrin-dependent Endocytosis Glycosphingolipid Binding Positive Regulation Of Proteolysis Establishment Of Protein Localization To Membrane Protein Targeting Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of ERAD Pathway Response To Endoplasmic Reticulum Stress Oligosaccharide Binding Establishment Of Protein Localization To Organelle Tail-anchored Membrane Protein Insertion Into ER Membrane Negative Regulation Of Receptor Internalization Regulation Of Clathrin-dependent Endocytosis Leukocyte Tethering Or Rolling Regulation Of Protein Catabolic Process Regulation Of Proteolysis Sialic Acid Binding Leukocyte Adhesion To Vascular Endothelial Cell Protein Heterooligomerization Protein Insertion Into ER Membrane Proteasomal Protein Catabolic Process Negative Regulation Of Receptor-mediated Endocytosis Mitochondrial Small Ribosomal Subunit Cellular Localization Protein-membrane Adaptor Activity	Leukocyte Cell-cell Adhesion Cell Adhesion Regulation Of Cell-cell Adhesion Uropod Plasma Membrane Leukocyte Tethering Or Rolling Leukocyte Adhesion To Vascular Endothelial Cell Microvillus Membrane Regulation Of Platelet Aggregation Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Cell Migration Membrane To Membrane Docking Positive Regulation Of Cell-cell Adhesion Regulation Of Platelet Activation Cell Motility Regulation Of Interleukin-2 Production Positive Regulation Of Early Endosome To Late Endosome Transport Microvillus Regulation Of Immune System Process Positive Regulation Of Protein Localization To Early Endosome Filopodium Positive Regulation Of Protein Localization To Endosome Cell-cell Adhesion Positive Regulation Of Leukocyte Cell-cell Adhesion Immune System Process Golgi Lumen Establishment Of Epithelial Cell Apical/basal Polarity Diacylglycerol-dependent Serine/threonine Kinase Activity Leukocyte Activation Regulation Of Early Endosome To Late Endosome Transport T Cell Activation Establishment Of Apical/basal Cell Polarity Positive Regulation Of Immune System Process Regulation Of Cell Activation Glycosaminoglycan Binding Epithelial Cell Development Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Polarized Epithelial Cell Differentiation Cell Activation Cortical Cytoskeleton Gland Morphogenesis Establishment Of Epithelial Cell Polarity Regulation Of Leukocyte Cell-cell Adhesion Signaling Receptor Binding Actin Filament-based Process Plasma Membrane Raft Positive Regulation Of Interleukin-2 Production Establishment Of Endothelial Barrier