POLE3 and POLE4

Number of citations: 0 (PubMedID 10801849)
Data Source: HPRD (in vitro)

		POLE3	POLE4
Name		DNA polymerase epsilon 3, accessory subunit	DNA polymerase epsilon 4, accessory subunit
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Pericentric Heterochromatin Epsilon DNA Polymerase Complex CHRAC ATAC Complex	Nucleus Nucleoplasm Epsilon DNA Polymerase Complex ATAC Complex
	Molecular Function	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Chromatin DNA Binding Protein Heterodimerization Activity	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication DNA-templated DNA Replication Leading Strand Elongation Regulation Of DNA Replication Nucleosome Assembly Chromatin Remodeling DNA Damage Response Heterochromatin Formation DNA Biosynthetic Process	DNA-templated DNA Replication DNA Biosynthetic Process
Pathways		Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex	Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex
Drugs		Cladribine	Cladribine
GWAS		No GWAS studies recorded	Venous thromboembolism ( 33592630 )
Interacting Genes		6 interacting genes: APP CHRAC1 DR1 DRAP1 POLE4 SMARCA5	7 interacting genes: HSPA13 NFYB POLE POLE2 POLE3 PRKAR1B UBE3A
Entrez ID		54107	56655
HPRD ID		06274	16238
Ensembl ID		ENSG00000148229	ENSG00000115350
Uniprot IDs		Q9NRF9	Q9NR33
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Negative Cofactor 2 Complex Protein Heterodimerization Activity CHRAC Regulation Of Proteolysis Epsilon DNA Polymerase Complex Protein-containing Complex Assembly Protein-containing Complex Organization Response To Peptide Response To Cytokine ATAC Complex Response To Lead Ion Ficolin-1-rich Granule Lumen Regulation Of Protein Catabolic Process Regulation Of Macromolecule Metabolic Process DNA-directed DNA Polymerase Activity TBP-class Protein Binding Amyloid Fibril Formation Pericentric Heterochromatin Regulation Of Primary Metabolic Process Porphobilinogen Synthase Activity Proteasome Core Complex Binding Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Response To Mechanical Stimulus Regulation Of Cell Cycle Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Elastin Catabolic Process Protein-DNA Complex Assembly RNA Polymerase II General Transcription Initiation Factor Activity Regulation Of Plasma Membrane Raft Polarization Phosphatidylinositol 3-kinase Catalytic Subunit Binding Perisynaptic Extracellular Matrix Positive Regulation Of Interleukin-17-mediated Signaling Pathway Actin Ubiquitination Positive Regulation Of Chemokine (C-C Motif) Ligand 20 Production DNA-templated DNA Replication Cellular Component Assembly Regulation Of Growth Axon Development Regulation Of Cellular Component Organization Response To Vitamin Acetylcholine Receptor Activator Activity Immune Response Innate Immune Response	Epsilon DNA Polymerase Complex DNA-directed DNA Polymerase Activity Leading Strand Elongation DNA-templated DNA Replication DNA Biosynthetic Process DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation DNA Replication DNA Synthesis Involved In DNA Repair Sperm Entry Positive Regulation Of Golgi Lumen Acidification Lactosylceramide Biosynthetic Process