POLE3 and CHRAC1

Number of citations: 43 (PubMedID 10880450)
Data Source: HPRD (in vivo)

		POLE3	CHRAC1
Name		DNA polymerase epsilon 3, accessory subunit	chromatin accessibility complex subunit 1
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Pericentric Heterochromatin Epsilon DNA Polymerase Complex CHRAC ATAC Complex	Nucleus Pericentric Heterochromatin Epsilon DNA Polymerase Complex CHRAC
	Molecular Function	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Chromatin DNA Binding Protein Heterodimerization Activity	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Transferase Activity Nucleotidyltransferase Activity Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication DNA-templated DNA Replication Leading Strand Elongation Regulation Of DNA Replication Nucleosome Assembly Chromatin Remodeling DNA Damage Response Heterochromatin Formation DNA Biosynthetic Process	DNA-templated DNA Replication Regulation Of DNA Replication Nucleosome Assembly Chromatin Remodeling DNA Biosynthetic Process
Pathways		Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex	None
Drugs		Cladribine	None
GWAS		No GWAS studies recorded	Experiencing mood swings ( 29500382 )
Interacting Genes		6 interacting genes: APP CHRAC1 DR1 DRAP1 POLE4 SMARCA5	5 interacting genes: APP FAM9B POLE3 SMARCA5 UBC
Entrez ID		54107	54108
HPRD ID		06274	06275
Ensembl ID		ENSG00000148229	ENSG00000104472
Uniprot IDs		Q9NRF9	Q9NRG0
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Negative Cofactor 2 Complex Protein Heterodimerization Activity CHRAC Regulation Of Proteolysis Epsilon DNA Polymerase Complex Protein-containing Complex Assembly Protein-containing Complex Organization Response To Peptide Response To Cytokine ATAC Complex Response To Lead Ion Ficolin-1-rich Granule Lumen Regulation Of Protein Catabolic Process Regulation Of Macromolecule Metabolic Process DNA-directed DNA Polymerase Activity TBP-class Protein Binding Amyloid Fibril Formation Pericentric Heterochromatin Regulation Of Primary Metabolic Process Porphobilinogen Synthase Activity Proteasome Core Complex Binding Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Response To Mechanical Stimulus Regulation Of Cell Cycle Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Elastin Catabolic Process Protein-DNA Complex Assembly RNA Polymerase II General Transcription Initiation Factor Activity Regulation Of Plasma Membrane Raft Polarization Phosphatidylinositol 3-kinase Catalytic Subunit Binding Perisynaptic Extracellular Matrix Positive Regulation Of Interleukin-17-mediated Signaling Pathway Actin Ubiquitination Positive Regulation Of Chemokine (C-C Motif) Ligand 20 Production DNA-templated DNA Replication Cellular Component Assembly Regulation Of Growth Axon Development Regulation Of Cellular Component Organization Response To Vitamin Acetylcholine Receptor Activator Activity Immune Response Innate Immune Response	CHRAC Epigenetic Regulation Of Gene Expression Pericentric Heterochromatin Acetylcholine Receptor Activator Activity Amyloid-beta Complex Growth Cone Lamellipodium Chromatin Remodeling Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Lipoprotein Particle Positive Regulation Of Protein Import WICH Complex Negative Regulation Of Mitotic Chromosome Condensation Nucleosome Assembly ISWI-type Complex Regulation Of DNA Replication NoRC Complex Histone Octamer Slider Activity RSF Complex ACF Complex Nucleosome Organization PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Heterochromatin Formation Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Chromatin Organization Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling CERF Complex Negative Regulation Of Chromosome Condensation Negative Regulation Of Gene Expression, Epigenetic Leading Strand Elongation Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Nucleosome Array Spacer Activity Protein-DNA Complex Assembly Epsilon DNA Polymerase Complex