PRRX1 and MAFF

Number of citations: 0 (PubMedID 11036080)
Data Source: HPRD (in vitro)

		PRRX1	MAFF
Name		paired related homeobox 1	MAF bZIP transcription factor F
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol	Chromatin Nucleus Nucleoplasm Mitochondrion RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding HMG Box Domain Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Smoothened Signaling Pathway Mesenchymal Cell Proliferation Embryonic Limb Morphogenesis Inner Ear Morphogenesis Middle Ear Morphogenesis Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Determination Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Morphogenesis Artery Morphogenesis Cartilage Development Roof Of Mouth Development Regulation Of Neuron Projection Regeneration Stem Cell Proliferation Neuronal Stem Cell Population Maintenance Positive Regulation Of Stem Cell Proliferation	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Parturition Skeletal Muscle Cell Differentiation Regulation Of Epidermal Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		None	Factors involved in megakaryocyte development and platelet production Factors involved in megakaryocyte development and platelet production
GWAS		A body shape index ( 34021172 ) Appendicular lean mass ( 33097823 ) Atrial fibrillation ( 22544366 29892015 29290336 28416822 28416818 ) Calcific aortic valve stenosis ( 32141789 ) Central corneal thickness ( 32528159 ) Early onset atrial fibrillation ( 28460022 ) Emphysema imaging phenotypes ( 26030696 ) Estimated glomerular filtration rate ( 31152163 ) Heel bone mineral density ( 28869591 30598549 ) Height ( 31562340 ) Hip circumference adjusted for BMI ( 34021172 28552196 25673412 ) Hip index ( 34021172 ) Intraocular pressure ( 29617998 ) Macular thickness ( 30535121 ) Male-pattern baldness ( 28196072 29146897 ) PR interval ( 32439900 ) Prevalent atrial fibrillation ( 28416818 ) Refractive error ( 32231278 ) Response to angiotensin II receptor blocker therapy ( 22566498 ) Systemic lupus erythematosus ( 33536424 ) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )	Alanine aminotransferase levels ( 33547301 ) Birth weight ( 31043758 ) Estimated glomerular filtration rate ( 31451708 31152163 31015462 ) Estimated glomerular filtration rate in non-diabetics ( 31451708 ) Fasting plasma glucose ( 32902719 ) HDL cholesterol ( 30275531 ) HDL cholesterol levels in current drinkers ( 30698716 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Height ( 31562340 ) Hemoglobin ( 32888494 ) High light scatter reticulocyte count ( 32888494 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Red blood cell count ( 32888494 ) Refractive error ( 32231278 ) Reticulocyte count ( 32888494 ) Serum alkaline phosphatase levels ( 33547301 ) Triglyceride levels ( 32154731 30698716 ) Triglyceride levels in current drinkers ( 30698716 ) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Triglycerides ( 30275531 ) Waist circumference adjusted for body mass index ( 34021172 )
Interacting Genes		8 interacting genes: CINP GTF2I MAFF MAFG SAAL1 SOX10 SRF SUOX	20 interacting genes: ATF3 BACH2 BATF2 BATF3 DDIT3 FOS GTF2A1L HDAC5 HOXD12 MAFIP NFE2 NFE2L1 NFE2L2 NFIL3 NR3C1 NRF1 OVOL1 PPARG PRRX1 PSAP
Entrez ID		5396	23764
HPRD ID		01337	05343
Ensembl ID		ENSG00000116132	ENSG00000185022
Uniprot IDs		P54821	Q9ULX9
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Multicellular Organism Development Chordate Embryonic Development In Utero Embryonic Development Embryo Development Ending In Birth Or Egg Hatching DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding Regulation Of Multicellular Organismal Process Positive Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Regulation Of Epidermis Development Negative Regulation Of RNA Biosynthetic Process Regulation Of Epidermal Cell Differentiation Serum Response Element Binding Sulfite Oxidase Activity Protein Transport Into Plasma Membrane Raft Regulation Of Multicellular Organismal Development Negative Regulation Of RNA Metabolic Process Bronchus Cartilage Development Lung Smooth Muscle Development Protein Transport Into Membrane Raft DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Population Proliferation Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Flavin-dependent Sulfhydryl Oxidase Activity Stem Cell Differentiation Cellular Response To Progesterone Stimulus Trachea Cartilage Development Cardiac Vascular Smooth Muscle Cell Differentiation Molybdenum Ion Binding Positive Regulation Of Synoviocyte Proliferation Positive Regulation Of Potassium Ion Import Across Plasma Membrane Protein Localization To Plasma Membrane Raft Positive Regulation Of Biosynthetic Process RNA Polymerase II Transcription Regulator Complex Molybdopterin Cofactor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulator Complex DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity DNA Binding Chromatin Integrated Stress Response Signaling DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Nucleus Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Mononuclear Cell Differentiation Negative Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Sequence-specific Double-stranded DNA Binding Protein-DNA Complex Leukocyte Differentiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Myeloid Cell Differentiation Regulation Of Macromolecule Metabolic Process Transcription Cis-regulatory Region Binding Positive Regulation Of Transcription By RNA Polymerase II Myeloid Leukocyte Differentiation Positive Regulation Of Macromolecule Biosynthetic Process CHOP-ATF3 Complex Positive Regulation Of Biosynthetic Process Identical Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Cell Redox Homeostasis Transcription Coregulator Binding Negative Regulation Of Biosynthetic Process Transcription By RNA Polymerase II Cell Differentiation Positive Regulation Of Metabolic Process