PRKAG3 and NGRN

Number of citations: 0 (PubMedID 19616115)
Data Source: BioGRID (two hybrid)

		PRKAG3	NGRN
Name		protein kinase AMP-activated non-catalytic subunit gamma 3	neugrin, neurite outgrowth associated
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Nucleotide-activated Protein Kinase Complex	Extracellular Region Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Membrane Nuclear Body Mitochondrial Membrane Intercellular Bridge Mitotic Spindle
	Molecular Function	Nucleotide Binding AMP-activated Protein Kinase Activity Protein Binding ATP Binding AMP Binding Protein Kinase Regulator Activity Protein Kinase Binding	RNA Binding Protein Binding RRNA Binding
	Biological Process	Regulation Of Glycolytic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Cellular Response To Nutrient Levels Intracellular Signal Transduction Cellular Response To Glucose Starvation Regulation Of Carbon Utilization Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Gluconeogenesis Regulation Of Cell Cycle	Cell Differentiation Neuron Differentiation Mitochondrial Ribosome Assembly Positive Regulation Of Mitochondrial Translation
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	rRNA modification in the mitochondrion Mitochondrial mRNA modification
Drugs		Adenosine phosphate Acetylsalicylic acid Fostamatinib	None
GWAS		Apolipoprotein A1 levels ( 32203549 ) HDL cholesterol ( 25961943 ) HDL cholesterol levels ( 32203549 ) High density lipoprotein cholesterol levels ( 33339817 ) Lymphocyte count ( 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Male-pattern baldness ( 28196072 ) Triglyceride levels ( 32203549 33339817 )	Cerebral amyloid angiopathy in Alzheimer’s disease ( 34020725 ) Multiple sclerosis ( 31604244 )
Interacting Genes		6 interacting genes: BRCA1 CRYAB KRTAP19-5 LMCD1 NGRN PRKAA1	6 interacting genes: DNMT1 GTF2H5 PRKAG3 SHANK3 TSC22D2 YOD1
Entrez ID		53632	51335
HPRD ID		16085	14825
Ensembl ID		ENSG00000115592	ENSG00000182768
Uniprot IDs		Q9UGI9	Q9NPE2
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Response To Ionizing Radiation Protein K6-linked Ubiquitination Negative Regulation Of Reactive Oxygen Species Metabolic Process Response To Gamma Radiation Negative Regulation Of Lipid Biosynthetic Process Response To Radiation Cellular Response To Ionizing Radiation Negative Regulation Of Glucosylceramide Biosynthetic Process Histone H2AK127 Ubiquitin Ligase Activity Fatty Acid Biosynthetic Process Histone H2AK129 Ubiquitin Ligase Activity Negative Regulation Of Lipid Metabolic Process BRCA1-BARD1 Complex Response To Hydrogen Peroxide Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Regulation Of Reactive Oxygen Species Metabolic Process BRCA1-B Complex Negative Regulation Of Cell Growth Nuclear Ubiquitin Ligase Complex Cellular Response To Indole-3-methanol BRCA1-C Complex Cellular Response To Radiation Protein-containing Complex Response To Indole-3-methanol Regulation Of Lipid Biosynthetic Process Response To Reactive Oxygen Species Response To Temperature Stimulus Negative Regulation Of Ceramide Biosynthetic Process Negative Regulation Of Tubulin Deacetylation Cold Acclimation Positive Regulation Of Mitochondrial Transcription Negative Regulation Of Sphingolipid Biosynthetic Process CAMP-dependent Protein Kinase Activity Negative Regulation Of Hepatocyte Apoptotic Process AMP-activated Protein Kinase Activity Positive Regulation Of Translation Protein Localization To Lipid Droplet CAMKK-AMPK Signaling Cascade Mitochondrial Ribosome Assembly Negative Regulation Of Centriole Replication Negative Regulation Of Growth Negative Regulation Of Apoptotic Process Cardiac Myofibril Regulation Of Tubulin Deacetylation Lipid Droplet Disassembly Negative Regulation Of Programmed Cell Death BRCA1-A Complex Ubiquitin-modified Histone Reader Activity Protein Stabilization	Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching DNA-methyltransferase Activity Chromosomal DNA Methylation Maintenance Following DNA Replication Regulation Of Phenotypic Switching Germ Cell Nucleus Cellular Response To Bisphenol A DNA (cytosine-5-)-methyltransferase Activity Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Regulation Of Carbon Utilization Protein K33-linked Deubiquitination Protein K29-linked Deubiquitination Protein K27-linked Deubiquitination Guanylate Kinase-associated Protein Clustering Negative Regulation Of Cell Volume AMPA Glutamate Receptor Clustering Synaptic Receptor Adaptor Activity Positive Regulation Of Synapse Structural Plasticity NMDA Glutamate Receptor Clustering Striatal Medium Spiny Neuron Differentiation Nucleotide-excision Repair, Preincision Complex Assembly Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Response To Bisphenol A AMP-activated Protein Kinase Activity Postsynaptic Density Assembly Regulation Of Synapse Structural Plasticity Transcription Elongation By RNA Polymerase I Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Nucleotide-activated Protein Kinase Complex Negative Regulation Of Glycogen Biosynthetic Process AMP Binding Negative Regulation Of Protein Exit From Endoplasmic Reticulum Protein K11-linked Deubiquitination Negative Regulation Of Retrograde Protein Transport, ER To Cytosol Vocal Learning Positive Regulation Of Glutamate Receptor Signaling Pathway Neuron Spine Positive Regulation Of Long-term Neuronal Synaptic Plasticity GABAergic Neuron Differentiation Regulation Of Glutamate Receptor Signaling Pathway Observational Learning Postsynaptic Specialization Assembly Transcription Factor TFIIH Core Complex Female Germ Cell Nucleus Regulation Of Retrograde Protein Transport, ER To Cytosol Neurotransmitter-gated Ion Channel Clustering Transcription Factor TFIIH Holo Complex Auditory Behavior Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Regulation Of Long-term Synaptic Depression Protein Kinase Regulator Activity