ATP6V1G2 and ATP6V1E1

Number of citations: 0 (PubMedID 14667819)
Data Source: HPRD (two hybrid)

		ATP6V1G2	ATP6V1E1
Name		ATPase H+ transporting V1 subunit G2	ATPase H+ transporting V1 subunit E1
Structure		No pdb structure
GO Annotations	Cellular Component	Vacuolar Proton-transporting V-type ATPase, V1 Domain Cytosol Membrane Vacuolar Proton-transporting V-type ATPase Complex Clathrin-coated Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Melanosome Extrinsic Component Of Synaptic Vesicle Membrane	Vacuolar Proton-transporting V-type ATPase, V1 Domain Cytoplasm Lysosomal Membrane Endosome Cytosol Plasma Membrane Microvillus Membrane Apical Plasma Membrane Proton-transporting Two-sector ATPase Complex Clathrin-coated Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Proton-transporting Two-sector ATPase Complex, Catalytic Domain Synapse Extracellular Exosome
	Molecular Function	Protein Binding ATP Hydrolysis Activity Proton-transporting ATPase Activity, Rotational Mechanism	Protein Binding Proton-transporting ATPase Activity, Rotational Mechanism ATPase Binding
	Biological Process	Monoatomic Ion Transport Regulation Of Macroautophagy Synaptic Vesicle Lumen Acidification Proton Transmembrane Transport	Monoatomic Ion Transport Regulation Of Macroautophagy Synaptic Vesicle Lumen Acidification Proton Transmembrane Transport
Pathways		ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport	ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy
Drugs		Tiludronic acid	Tiludronic acid
GWAS		Asthma ( 31619474 ) Asthma (childhood onset) ( 31619474 ) Asthma and major depressive disorder ( 31619474 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Inflammatory bowel disease ( 28067908 ) LDL cholesterol levels ( 32203549 ) Malaria ( 31844061 ) Monocyte percentage of white cells ( 32888494 ) Myositis ( 26291516 ) Ulcerative colitis ( 28067908 )	No GWAS studies recorded
Interacting Genes		3 interacting genes: ATP6V1E1 ATP6V1E2 USP20	14 interacting genes: ALDOA ALDOB ALDOC APP ATP6V0E1 ATP6V1G1 ATP6V1G2 ATP6V1H HSPB2 MESD NHERF1 SOS1 TRAF6 XRCC6
Entrez ID		534	529
HPRD ID		06030	00163
Ensembl ID		ENSG00000213760	ENSG00000131100
Uniprot IDs		O95670 Q6NVJ2	P36543 Q53Y06
PDB IDs		Not available	6WLZ 6WM2 6WM3 6WM4 7U4T 7UNF
GO Terms Enriched among Interactors		Proton-transporting Two-sector ATPase Complex, Catalytic Domain Proton-transporting ATPase Activity, Rotational Mechanism Regulation Of Autophagy Proton Transmembrane Transport Regulation Of Macroautophagy Proton-transporting Two-sector ATPase Complex Vacuolar Proton-transporting V-type ATPase, V1 Domain Inorganic Ion Transmembrane Transport Monoatomic Cation Transmembrane Transport Synaptic Vesicle Lumen Acidification Inorganic Cation Transmembrane Transport Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Clathrin-coated Vesicle Membrane	Fructose-bisphosphate Aldolase Activity Proton-transporting ATPase Activity, Rotational Mechanism Fructose 1,6-bisphosphate Metabolic Process Homeostatic Process Vacuolar Proton-transporting V-type ATPase, V1 Domain Fructose Metabolic Process Extrinsic Component Of Synaptic Vesicle Membrane Cellular Homeostasis Proton-transporting V-type ATPase Complex ADP Catabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Lyase Activity Glycolytic Process Growth Factor Receptor Binding Proton Transmembrane Transport ADP Metabolic Process Nucleoside Diphosphate Catabolic Process Fructose Binding Ribonucleoside Diphosphate Catabolic Process Regulation Of Macroautophagy Pyruvate Metabolic Process Cytoskeletal Protein Binding Ribonucleoside Diphosphate Metabolic Process Purine Ribonucleotide Catabolic Process Nucleoside Diphosphate Metabolic Process Purine Nucleotide Catabolic Process Intracellular Chemical Homeostasis Vacuolar Proton-transporting V-type ATPase Complex Regulation Of Phosphorus Metabolic Process Nucleotide Catabolic Process Synaptic Vesicle Lumen Acidification Nicotinamide Nucleotide Metabolic Process Carbohydrate Catabolic Process Secretory Granule Lumen Ficolin-1-rich Granule Lumen Nucleoside Phosphate Catabolic Process Fc-epsilon Receptor Signaling Pathway ATP Hydrolysis Activity Regulation Of Autophagy Low-density Lipoprotein Particle Receptor Binding Monoatomic Cation Transport Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis ATP Metabolic Process Hexose Metabolic Process Organophosphate Catabolic Process Clathrin-coated Vesicle Membrane Cytosol Monosaccharide Metabolic Process Vacuolar Acidification