PITPNA and SCP2

Number of citations: 0 (PubMedID 15182174)
Data Source: BioGRID (fluorescent resonance energy transfer)

		PITPNA	SCP2
Name		phosphatidylinositol transfer protein alpha	sterol carrier protein 2
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Extracellular Exosome	Nucleoplasm Cytoplasm Mitochondrion Peroxisome Peroxisomal Matrix Endoplasmic Reticulum Cytosol Membrane Protein-containing Complex
	Molecular Function	Protein Binding Phospholipid Transporter Activity Lipid Binding Phosphatidylcholine Transporter Activity Phosphatidylinositol Transfer Activity Phosphatidylcholine Binding Phosphatidylinositol Binding Quaternary Ammonium Group Binding Phosphatidylcholine Transfer Activity Phosphatidylglycerol Binding	Fatty-acyl-CoA Binding Acetyl-CoA C-acyltransferase Activity Signaling Receptor Binding Protein Binding Lipid Binding Phosphatidylinositol Transfer Activity Cholesterol Binding Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Propanoyl-CoA C-acyltransferase Activity Long-chain Fatty Acyl-CoA Binding Propionyl-CoA C2-trimethyltridecanoyltransferase Activity Acetyl-CoA C-myristoyltransferase Activity Oleic Acid Binding Phosphatidylcholine Transfer Activity Cholesterol Transfer Activity
	Biological Process	Lipid Metabolic Process Lipid Transport Axonogenesis Visual Perception Phospholipid Transport Intermembrane Lipid Transfer	Lipid Metabolic Process Fatty Acid Beta-oxidation Unsaturated Fatty Acid Biosynthetic Process Steroid Biosynthetic Process Bile Acid Biosynthetic Process Progesterone Biosynthetic Process Lipid Transport Bile Acid Metabolic Process Phospholipid Transport Sterol Transport Regulation Of Lipid Metabolic Process Intracellular Cholesterol Transport Positive Regulation Of Intracellular Cholesterol Transport Inositol Trisphosphate Biosynthetic Process Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Positive Regulation Of Steroid Metabolic Process Regulation Of Phospholipid Biosynthetic Process Protein Localization To Plasma Membrane Intermembrane Lipid Transfer Lipid Hydroperoxide Transport Fatty Acid Derivative Biosynthetic Process
Pathways		Role of second messengers in netrin-1 signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	alpha-linolenic acid (ALA) metabolism Peroxisomal protein import Peroxisomal protein import TYSND1 cleaves peroxisomal proteins
Drugs		1,2-diacyl-sn-glycero-3-phosphoinositol (Z,Z)-4-Hydroxy-N,N,N-Trimethyl-10-Oxo-7-[(1-Oxo-9-Octadecenyl)Oxy]-3,5,9-Trioxa-4-Phosphaheptacos-18-En-1-Aminium-4-Oxide	None
Diseases		None	Leukoencephalopathy with dystonia and motor neuropathy Peroxisomal beta-oxidation enzyme deficiency, including: Acyl-CoA oxidase (ACOX) deficiency; D-bifunctional protein (DBP) deficiency; Perrault syndrome; Sterol carrier protein X (SCPx) deficiency; 2-Methylacyl-CoA racemase (AMCR) deficiency; Hypercholanemia
GWAS		Metabolite levels ( 23823483 ) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814 )	No GWAS studies recorded
Interacting Genes		9 interacting genes: CSNK2B DCC EGFR NEO1 PI4KA PIK3C3 PLCG1 SCP2 UBC	11 interacting genes: ACAA2 ACOX1 CACNA1A CAV1 CEBPA CREB3 EHHADH OGT PEX5 PITPNA TRIP13
Entrez ID		5306	6342
HPRD ID		02548	01700
Ensembl ID		ENSG00000174238	ENSG00000116171
Uniprot IDs		B4E1U1 Q00169 V9HWC5	A0A384NY87 B2R761 E9PLD1 P22307 Q59HG9
PDB IDs		1UW5 8PQO	1QND 2C0L
GO Terms Enriched among Interactors		Phosphatidylinositol-mediated Signaling Intracellular Vesicle Phosphatidylinositol Metabolic Process Phosphate-containing Compound Metabolic Process Plasma Membrane Cytosol Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Multivesicular Body, Internal Vesicle Lumen Epidermal Growth Factor Receptor Signaling Pathway Phosphatidylinositol Phosphate Biosynthetic Process Glycerophospholipid Metabolic Process Reorganization Of Cellular Membranes To Establish Viral Sites Of Replication Propionyl-CoA C2-trimethyltridecanoyltransferase Activity Propanoyl-CoA C-acyltransferase Activity Cadherin Binding Glycerolipid Metabolic Process Phospholipid Metabolic Process Regulation Of Viral Life Cycle Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Catabolic Process Negative Regulation Of Protein Catabolic Process Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Blood Vessel Endothelial Cell Migration Postsynaptic Density Membrane Dorsal/ventral Axon Guidance Cell Migration Cell Motility Spinal Cord Ventral Commissure Morphogenesis Negative Regulation Of Neuron Projection Development Response To Amino Acid Ruffle Membrane Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Focal Adhesion ERBB Signaling Pathway Epidermal Growth Factor Binding Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Shc-EGFR Complex Lipid Metabolic Process Organophosphate Metabolic Process Peroxisome Host-mediated Perturbation Of Viral Process Positive Regulation Of Protein Lipidation Phosphatidylinositol Biosynthetic Process Phosphatidylinositol 3-kinase Complex, Class III, Type II Phosphatidylinositol 3-kinase Complex, Class III, Type I Modulation Of Process Of Another Organism Host-mediated Perturbation Of Symbiont Process	Fatty Acid Beta-oxidation Lipid Oxidation Fatty Acid Catabolic Process Fatty Acid Oxidation Lipid Metabolic Process Lipid Modification Peroxisomal Matrix Carboxylic Acid Catabolic Process Lipid Catabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Negative Regulation Of Cellular Component Organization Peroxisome Lipid Homeostasis Monocarboxylic Acid Metabolic Process Regulation Of Necroptotic Process Cellular Response To Stress Long-chain Fatty Acid Biosynthetic Process Very Long-chain Fatty Acid Metabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Programmed Necrotic Cell Death Integrated Stress Response Signaling Organelle Organization Unsaturated Fatty Acid Biosynthetic Process Fatty Acid Derivative Biosynthetic Process Mitochondrion Organization Very Long-chain Fatty Acid Beta-oxidation Inward Rectifier Potassium Channel Inhibitor Activity Membrane Organization RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Deacetylase Activity Peroxisomal Membrane Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Protein-containing Complex Negative Regulation Of Protein Ubiquitination Fatty Acid Derivative Metabolic Process Small Molecule Metabolic Process Response To Stress Caveolar Macromolecular Signaling Complex Negative Regulation Of Cell Cycle Response To Vitamin B2 C/EBP Complex Long-chain (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Intramolecular Oxidoreductase Activity, Transposing C=C Bonds Peroxisome Membrane Targeting Sequence Binding