PITPNA and PI4KA

Number of citations: 0 (PubMedID 7761838)
Data Source: HPRD (in vivo)

		PITPNA	PI4KA
Name		phosphatidylinositol transfer protein alpha	phosphatidylinositol 4-kinase alpha
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Extracellular Exosome	Cytoplasm Cytosol Plasma Membrane Focal Adhesion Membrane Golgi-associated Vesicle Membrane Extracellular Exosome
	Molecular Function	Protein Binding Phospholipid Transporter Activity Lipid Binding Phosphatidylcholine Transporter Activity Phosphatidylinositol Transfer Activity Phosphatidylcholine Binding Phosphatidylinositol Binding Quaternary Ammonium Group Binding Phosphatidylcholine Transfer Activity Phosphatidylglycerol Binding	Nucleotide Binding 1-phosphatidylinositol 4-kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Cadherin Binding
	Biological Process	Lipid Metabolic Process Lipid Transport Axonogenesis Visual Perception Phospholipid Transport Intermembrane Lipid Transfer	Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Signal Transduction Host-mediated Perturbation Of Viral Process Phosphatidylinositol Phosphate Biosynthetic Process Phosphatidylinositol-mediated Signaling Reorganization Of Cellular Membranes To Establish Viral Sites Of Replication
Pathways		Role of second messengers in netrin-1 signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Synthesis of PIPs at the ER membrane Synthesis of PIPs at the Golgi membrane
Drugs		1,2-diacyl-sn-glycero-3-phosphoinositol (Z,Z)-4-Hydroxy-N,N,N-Trimethyl-10-Oxo-7-[(1-Oxo-9-Octadecenyl)Oxy]-3,5,9-Trioxa-4-Phosphaheptacos-18-En-1-Aminium-4-Oxide	None
GWAS		Metabolite levels ( 23823483 ) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814 )	Fulminant type 1 diabetes ( 30552108 ) Metabolite levels ( 23823483 ) Monocyte percentage of white cells ( 32888494 )
Interacting Genes		9 interacting genes: CSNK2B DCC EGFR NEO1 PI4KA PIK3C3 PLCG1 SCP2 UBC	10 interacting genes: C8orf33 CD4 CD7 LCK MRPL44 MTNR1B PITPNA SNX9 STRN4 TNNT1
Entrez ID		5306	5297
HPRD ID		02548	08972
Ensembl ID		ENSG00000174238	ENSG00000241973
Uniprot IDs		B4E1U1 Q00169 V9HWC5	A0A140VK35 B4DYG5 P42356
PDB IDs		1UW5 8PQO	6BQ1 9B9G 9BAX
GO Terms Enriched among Interactors		Phosphatidylinositol-mediated Signaling Intracellular Vesicle Phosphatidylinositol Metabolic Process Phosphate-containing Compound Metabolic Process Plasma Membrane Cytosol Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Multivesicular Body, Internal Vesicle Lumen Epidermal Growth Factor Receptor Signaling Pathway Phosphatidylinositol Phosphate Biosynthetic Process Glycerophospholipid Metabolic Process Reorganization Of Cellular Membranes To Establish Viral Sites Of Replication Propionyl-CoA C2-trimethyltridecanoyltransferase Activity Propanoyl-CoA C-acyltransferase Activity Cadherin Binding Glycerolipid Metabolic Process Phospholipid Metabolic Process Regulation Of Viral Life Cycle Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Catabolic Process Negative Regulation Of Protein Catabolic Process Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Blood Vessel Endothelial Cell Migration Postsynaptic Density Membrane Dorsal/ventral Axon Guidance Cell Migration Cell Motility Spinal Cord Ventral Commissure Morphogenesis Negative Regulation Of Neuron Projection Development Response To Amino Acid Ruffle Membrane Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Focal Adhesion ERBB Signaling Pathway Epidermal Growth Factor Binding Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Shc-EGFR Complex Lipid Metabolic Process Organophosphate Metabolic Process Peroxisome Host-mediated Perturbation Of Viral Process Positive Regulation Of Protein Lipidation Phosphatidylinositol Biosynthetic Process Phosphatidylinositol 3-kinase Complex, Class III, Type II Phosphatidylinositol 3-kinase Complex, Class III, Type I Modulation Of Process Of Another Organism Host-mediated Perturbation Of Symbiont Process	None