SERPINB6 and PROC

Number of citations: 0 (PubMedID 7548163)
Data Source: HPRD (in vitro)

		SERPINB6	PROC
Name		serpin family B member 6	protein C, inactivator of coagulation factors Va and VIIIa
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Secretory Granule Membrane Extracellular Matrix Extracellular Exosome Tertiary Granule Membrane Serine Protease Inhibitor Complex Ficolin-1-rich Granule Membrane	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Golgi Lumen
	Molecular Function	Protease Binding Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity	Endopeptidase Activity Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Sensory Perception Of Sound Cellular Response To Osmotic Stress	Proteolysis Blood Coagulation Hemostasis Negative Regulation Of Blood Coagulation Negative Regulation Of Apoptotic Process Negative Regulation Of Inflammatory Response Negative Regulation Of Coagulation Positive Regulation Of Establishment Of Endothelial Barrier
Pathways		Neutrophil degranulation Dissolution of Fibrin Clot	Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Drotrecogin alfa	Menadione Sodium tetradecyl sulfate Cupric Chloride Kappadione Protein S human
Diseases		None	Inherited thrombophilia
GWAS		Chronic lymphocytic leukemia ( 26956414 ) Crohn's disease ( 32581322 )	Blood protein levels ( 30072576 ) Protein C levels ( 20802025 25376901 28082259 )
Interacting Genes		8 interacting genes: F10 F2 KLK2 MYCBP2 PLAU PLG PROC SUMO2	15 interacting genes: CP CSNK2B CYSRT1 F2 F5 F8 GGCX KLK1 PF4 PROCR PROS1 SERPINA5 SERPINB6 THBD TK1
Entrez ID		5269	5624
HPRD ID		01413	01466
Ensembl ID		ENSG00000124570	ENSG00000115718
Uniprot IDs		A0A024QZX5 A0A087X1N8 A0A2R8YD12 P35237	B4DPC8 B4DPQ3 E7END6 P04070
PDB IDs		Not available	1AUT 1LQV 3F6U 3JTC 4DT7 6M3B 6M3C 8JRU 8JRV 9BVM
GO Terms Enriched among Interactors		Serine-type Peptidase Activity Serine-type Endopeptidase Activity Coagulation Blood Coagulation Hemostasis Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Peptidase Activity Negative Regulation Of Fibrinolysis Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Regulation Of Fibrinolysis Regulation Of Body Fluid Levels Fibrinolysis Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Regulation Of Wound Healing Protein Metabolic Process Regulation Of Response To Wounding Proteolysis Positive Regulation Of Wound Healing Endopeptidase Activity Extracellular Space Golgi Lumen External Side Of Plasma Membrane Hydrolase Activity Macromolecule Metabolic Process Protein Processing Extracellular Region Biological Process Involved In Interaction With Symbiont Zymogen Activation Regulation Of Biological Quality Endoplasmic Reticulum Lumen Protein Maturation Regulation Of Proteolysis Regulation Of Locomotion Urokinase Plasminogen Activator Signaling Pathway Negative Regulation Of Multicellular Organismal Process Blood Microparticle Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Receptor Ligand Activity Positive Regulation Of Cell Migration Negative Regulation Of Proteolysis Thrombospondin Receptor Activity Positive Regulation Of Cell Motility Regulation Of Smooth Muscle Cell-matrix Adhesion Trans-synaptic Signaling By BDNF Positive Regulation Of Fibrinolysis	Coagulation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Negative Regulation Of Coagulation Extracellular Space Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Platelet Alpha Granule Lumen Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Extracellular Region Biological Process Involved In Interaction With Symbiont Endoplasmic Reticulum Lumen Regulation Of Wound Healing Copper Ion Binding Regulation Of Response To Wounding Extracellular Exosome Negative Regulation Of Fibrinolysis Golgi Lumen Regulation Of Fibrinolysis Negative Regulation Of Platelet Activation Fibrinolysis Platelet Alpha Granule Protease Binding Protein Activation Cascade Blood Microparticle Protein Maturation Positive Regulation Of Blood Coagulation Regulation Of Biological Quality Positive Regulation Of Coagulation Killing By Host Of Symbiont Cells Heparin Binding Extracellular Matrix Negative Regulation Of Multicellular Organismal Process COPII-coated ER To Golgi Transport Vesicle Zymogen Activation Acute-phase Response Oxidoreductase Activity, Acting On Metal Ions, Oxygen As Acceptor Gamma-glutamyl Carboxylase Activity Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-coagulation Factor XI Complex