SERPINA1 and RAP2A

Number of citations: 0 (PubMedID 18624398)
Data Source: BioGRID (two hybrid)

		SERPINA1	RAP2A
Name		serpin family A member 1	RAP2A, member of RAS oncogene family
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus COPII-coated ER To Golgi Transport Vesicle Extracellular Matrix Platelet Alpha Granule Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Extracellular Exosome Ficolin-1-rich Granule Lumen	Lysosome Endosome Golgi Apparatus Cytosol Plasma Membrane Endomembrane System Membrane Midbody Cytoplasmic Vesicle Membrane Lamellipodium Membrane Endolysosome Cell Projection Synapse Recycling Endosome Recycling Endosome Membrane Synaptic Membrane Bounding Membrane Of Organelle Schaffer Collateral - CA1 Synapse
	Molecular Function	Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity Identical Protein Binding	Nucleotide Binding Magnesium Ion Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding
	Biological Process	Acute-phase Response Blood Coagulation Hemostasis	Signal Transduction Intracellular Protein Localization Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Rap Protein Signal Transduction Establishment Of Protein Localization Regulation Of JNK Cascade Regulation Of Dendrite Morphogenesis Regulation Of Synapse Assembly Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Microvillus Assembly
Pathways		Platelet degranulation COPII-mediated vesicle transport Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Cargo concentration in the ER Neutrophil degranulation Post-translational protein phosphorylation	None
Drugs		Zinc 2-[3,4-Dihydroxy-2-Hydroxymethyl-5-(2-Hydroxy-Nonyl)-Tetrahydro-Furan-2-Yloxy]-6-Hydroxymethyl-Tetra Hydro-Pyran-3,4,5-Triol Mercaptoethanol Recombinant alpha 1-antitrypsin PPL-100 Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate
Diseases		Alpha-1-antitrypsin (A1AT) deficiency	None
GWAS		Age at first sexual intercourse ( 34211149 ) Alanine aminotransferase levels ( 34315874 33339817 ) Alanine transaminase levels ( 28887542 ) Alcohol consumption ( 31358974 ) Alcohol consumption (drinks per week) ( 30679032 30643258 ) Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956 28029757 ) Appendicular lean mass ( 33097823 ) Aspartate aminotransferase levels ( 34315874 ) Bitter alcoholic beverage consumption ( 31046077 ) Blood protein levels ( 23696881 ) Brain morphology (MOSTest) ( 32665545 ) Breast size ( 27182965 ) C-reactive protein levels ( 33227023 30388399 ) Cirrhosis (alcohol related) ( 32853455 ) Cirrhosis (multi-trait analysis) ( 33310085 ) Coronary artery disease ( 29212778 ) Gallstone disease ( 30504769 ) Glucagon levels in response to oral glucose tolerance test (fasting) ( 29093273 ) Height ( 29782485 28552196 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Hip circumference adjusted for BMI ( 34021172 ) Iron status biomarkers (total iron binding capacity) ( 33536631 ) Large artery stroke ( 28265093 ) LDL cholesterol ( 30275531 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Low density lipoprotein cholesterol levels ( 32154731 ) Manganese levels ( 26025379 ) Metabolite levels ( 22916037 ) Myocardial infarction ( 33532862 ) Platelet count ( 27863252 ) Plateletcrit ( 32888494 ) Post bronchodilator FEV1 ( 26634245 ) Post bronchodilator FEV1/FVC ratio ( 26634245 ) Post bronchodilator FEV1/FVC ratio in smoking ( 30068317 ) Post bronchodilator percent predicted FEV1 in smoking ( 30068317 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Serum alkaline phosphatase levels ( 33339817 31666285 ) Serum alpha-fetoprotein levels ( 31666285 ) Sucrose liking ( 31005972 ) Total cholesterol levels ( 30275531 ) Waist circumference adjusted for body mass index ( 34021172 )	Gut microbiota (bacterial taxa) ( 27723756 ) Peripheral artery disease ( 26488411 )
Interacting Genes		30 interacting genes: ADAMTS4 ATP5F1C CELA1 CTRB1 CTSG DERL2 DERL3 ECHS1 ELANE GLP1R GSDMB HSP90AA1 KLK1 KLK3 KLK5 LAMTOR5 LRP1 MMP11 MMP26 MMP7 PRSS1 PRSS2 PRSS3 PRTN3 RAP2A RCHY1 SDC2 SLC13A1 SMAD4 VKORC1	32 interacting genes: ACVR1 AFDN ARHGAP29 BMPR1B EEF1A1 ENSA FKBP2 FNTB FTL GABARAPL2 GRIN1 GRIN2D MAP4K4 NEDD4 PLG RAB40B RAF1 RALGDS RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASIP1 RASSF5 RGS14 RRP9 RUNDC3A SERPINA1 SMAD1 TGFBR1 TM7SF2 TNIK
Entrez ID		5265	5911
HPRD ID		02463	01547
Ensembl ID		ENSG00000197249	ENSG00000125249
Uniprot IDs		A0A024R6N5 A0A384MDQ7 E9KL23 P01009	P10114
PDB IDs		1ATU 1D5S 1EZX 1HP7 1IZ2 1KCT 1OO8 1OPH 1PSI 1QLP 1QMB 2D26 2QUG 3CWL 3CWM 3DRM 3DRU 3NDD 3NDF 3NE4 3T1P 4PYW 5IO1 5NBU 5NBV 6HX4 6I4V 6I7U 6IAY 6ROD 7AEL 7API 7NPK 7NPL 8API 8P4J 8P4U 8PI2 8QZ5 8R13 8R21 9API	1KAO 2RAP 3RAP
GO Terms Enriched among Interactors		Serine-type Endopeptidase Activity Serine-type Peptidase Activity Peptidase Activity Extracellular Matrix Disassembly Proteolysis Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Hydrolase Activity Protein Metabolic Process Extracellular Space Collagen Catabolic Process Extracellular Region Collagen Metabolic Process Digestion Metalloendopeptidase Activity Secretory Granule Catabolic Process Macromolecule Metabolic Process Antibacterial Peptide Biosynthetic Process Response To Other Organism Positive Regulation Of Antibacterial Peptide Production Azurophil Granule Lumen Killing By Host Of Symbiont Cells Biological Process Involved In Interaction With Symbiont Zymogen Activation Regulation Of Antibacterial Peptide Production Positive Regulation Of Antimicrobial Peptide Production Positive Regulation Of Antimicrobial Humoral Response Response To External Biotic Stimulus Signal Recognition Particle Binding Metallopeptidase Activity Negative Regulation Of Retrograde Protein Transport, ER To Cytosol Response To Stress Negative Regulation Of Protein Exit From Endoplasmic Reticulum Regulation Of Antimicrobial Humoral Response Neutrophil-mediated Killing Of Bacterium Antimicrobial Humoral Response Defense Response To Bacterium Positive Regulation Of Defense Response To Bacterium Protein Maturation Regulation Of Retrograde Protein Transport, ER To Cytosol Protein Processing Regulation Of Defense Response To Bacterium Defense Response Endopeptidase Activity Defense Response To Gram-negative Bacterium Positive Regulation Of Humoral Immune Response Response To Bacterium Neutrophil Mediated Immunity	Intracellular Signaling Cassette Signal Transduction Transforming Growth Factor Beta Receptor Activity, Type I Intracellular Signal Transduction Ras Protein Signal Transduction Small GTPase-mediated Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Activity Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling GTPase Regulator Activity Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Microvillus Assembly Protein Kinase Activity Establishment Of Endothelial Barrier Activin Receptor Complex Activin Receptor Activity, Type I NMDA Glutamate Receptor Activity Glutamate Binding Endothelial Cell Development Guanyl-nucleotide Exchange Factor Activity BMP Receptor Activity Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition SMAD Binding NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity Positive Regulation Of Signal Transduction Kinase Activity Potassium Channel Inhibitor Activity Excitatory Chemical Synaptic Transmission Regulation Of Microvillus Assembly Activin Binding Cellular Response To Growth Factor Stimulus Enzyme-linked Receptor Protein Signaling Pathway Plasma Membrane Regulation Of Type B Pancreatic Cell Proliferation Regulation Of Intracellular Signal Transduction Protein Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction Nucleotide Binding Regulation Of Insulin Secretion Response To Growth Factor Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Osteoblast Differentiation Regulation Of Cartilage Development Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway I-SMAD Binding Positive Regulation Of Cellular Component Biogenesis