PEX7 and ACAT1

Number of citations: 65 (PubMedID 22057399)
Data Source: BioGRID (two hybrid)

		PEX7	ACAT1
Name		peroxisomal biogenesis factor 7	acetyl-CoA acetyltransferase 1
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Peroxisome Peroxisomal Membrane Peroxisomal Matrix Cytosol	Mitochondrion Mitochondrial Matrix Endoplasmic Reticulum Extracellular Exosome
	Molecular Function	Peroxisome Matrix Targeting Signal-2 Binding Protein Binding Enzyme Binding Protein Homodimerization Activity	Acetyl-CoA C-acetyltransferase Activity C-acetyltransferase Activity Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Enzyme Binding Potassium Ion Binding Cholesterol O-acyltransferase Activity Identical Protein Binding Metal Ion Binding Coenzyme A Binding
	Biological Process	Neuron Migration Endochondral Ossification Protein Targeting To Peroxisome Fatty Acid Beta-oxidation Peroxisome Organization Ether Lipid Biosynthetic Process Protein Transport Protein Import Into Peroxisome Matrix	Liver Development Acetyl-CoA Biosynthetic Process L-isoleucine Catabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Response To Hormone Coenzyme A Metabolic Process Coenzyme A Biosynthetic Process Response To Starvation Acetyl-CoA Catabolic Process Ketone Body Catabolic Process Adipose Tissue Development Metanephric Proximal Convoluted Tubule Development Ketone Body Metabolic Process Propionyl-CoA Biosynthetic Process
Pathways		Peroxisomal protein import Peroxisomal protein import	Branched-chain amino acid catabolism Utilization of Ketone Bodies Synthesis of Ketone Bodies Mitochondrial protein degradation Maturation of TCA enzymes and regulation of TCA cycle Beta-ketothiolase deficiency
Drugs		None	Sulfasalazine Cannabidiol Medical Cannabis Nabiximols
Diseases		Refsum disease; Heredopathia atactica polyneuritiformis Rhizomelic chondrodysplasia punctata, including: Rhizomelic chondrodysplasia punctata, type I (RCDP1); Rhizomelic chondrodysplasia punctata, type II (RCDP2); Rhizomelic chondrodysplasia punctata, type III (RCDP3)	None
GWAS		Caffeine consumption from coffee or tea ( 33287642 ) Caffeine consumption from tea ( 33287642 ) Lymphocyte percentage of white cells ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Neutrophil percentage of white cells ( 32888494 )	Nonunion in individuals with fractures ( 30680360 ) Refractive error ( 32231278 )
Interacting Genes		8 interacting genes: ACAT1 KDM1A PEX13 PEX14 PEX5 PEX5L PHYH PRMT6	4 interacting genes: AGXT PDP1 PEX7 PTPRF
Entrez ID		5191	38
HPRD ID		03454	01946
Ensembl ID		ENSG00000112357	ENSG00000075239
Uniprot IDs		A0A7I2V2J8 O00628 Q6FGN1	A0A140VJX1 A0A5F9ZHJ0 A0A5F9ZHL1 A0A5F9ZI66 P24752
PDB IDs		Not available	2F2S 2IB7 2IB8 2IB9 2IBU 2IBW 2IBY
GO Terms Enriched among Interactors		Protein Import Into Peroxisome Matrix, Docking Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Substrate Release Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Unfolding Peroxisomal Membrane Protein Import Into Peroxisome Matrix Fatty Acid Oxidation Fatty Acid Catabolic Process Lipid Oxidation Establishment Of Protein Localization To Peroxisome Peroxisomal Membrane Transport Peroxisome Matrix Targeting Signal-1 Binding Peroxisome Organization Receptor Recycling Peroxisome Intracellular Protein Transmembrane Transport Lipid Modification Peroxisomal Importomer Complex Peroxisome Targeting Sequence Binding Receptor Metabolic Process Protein Monoubiquitination Carboxylic Acid Catabolic Process Fatty Acid Alpha-oxidation Lipid Catabolic Process Protein Transmembrane Transport Fatty Acid Metabolic Process Cellular Response To Reactive Oxygen Species Small Molecule Metabolic Process Protein-containing Complex Disassembly Monocarboxylic Acid Metabolic Process Response To Reactive Oxygen Species Protein Transmembrane Transporter Activity Cerebral Cortex Cell Migration Cellular Response To Oxidative Stress Telencephalon Cell Migration Forebrain Cell Migration Carboxylic Acid Metabolic Process Cellular Response To Chemical Stress Peroxisomal Matrix Organic Acid Metabolic Process Fatty Acid Beta-oxidation Metanephric Proximal Convoluted Tubule Development Propionyl-CoA Biosynthetic Process C-acetyltransferase Activity Peroxisome Transport Along Microtubule 2-oxobutyrate Catabolic Process Phytanoyl-CoA Dioxygenase Activity Lipid Localization Histone H2AR3 Methyltransferase Activity	Peroxisomal Matrix L-serine-pyruvate Transaminase Activity Peroxisome Matrix Targeting Signal-2 Binding Chondroitin Sulfate Proteoglycan Binding Protein Dephosphorylation C-X-C Motif Chemokine 12 Receptor Activity Pyruvate Dehydrogenase (lipoamide) Phosphatase Complex Glycine Biosynthetic Process, By Transamination Of Glyoxylate Peroxisome Oxalic Acid Secretion Dephosphorylation Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway Phosphoprotein Phosphatase Activity Glycine Biosynthetic Process Glyoxylate Catabolic Process L-alanine Catabolic Process Alanine-glyoxylate Transaminase Activity L-alanine Metabolic Process L-cysteine Catabolic Process Cell Migration Negative Regulation Of Receptor Binding Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway [pyruvate Dehydrogenase (acetyl-transferring)]-phosphatase Activity Carboxylic Acid Catabolic Process CXCL12-activated CXCR4 Signaling Pathway Cell Motility Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Myosin Light Chain Binding C-X-C Chemokine Receptor CXCR4 Signaling Pathway Oxalate Transport Glyoxylate Metabolic Process Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway C-X-C Chemokine Receptor Activity Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Peptidyl-threonine Dephosphorylation Protein Targeting To Peroxisome Regulation Of Acyl-CoA Biosynthetic Process Sulfur Amino Acid Catabolic Process Cysteine Metabolic Process Serine Family Amino Acid Catabolic Process Ether Lipid Biosynthetic Process Glycine Metabolic Process Aldehyde Catabolic Process Amino Acid Binding L-serine Metabolic Process Protein Import Into Peroxisome Matrix Myelin Maintenance Cation Binding Transmembrane Receptor Protein Tyrosine Phosphatase Activity Dendritic Cell Chemotaxis