CDK5RAP1 and CDK5R1

Number of citations: 0 (PubMedID 11882646)
Data Source: HPRD (in vitro, in vivo)

		CDK5RAP1	CDK5R1
Name		CDK5RAP1 mitochondrial tRNA methylthiotransferase	cyclin dependent kinase 5 regulatory subunit 1
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Membrane Protein Kinase 5 Complex Axon Dendrite Growth Cone Neuromuscular Junction Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Perikaryon Contractile Muscle Fiber Perinuclear Region Of Cytoplasm
	Molecular Function	Catalytic Activity Transferase Activity Protein Kinase Binding Methylthiotransferase Activity TRNA-2-methylthio-N(6)-dimethylallyladenosine(37) Synthase Activity Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding	Protease Binding Actin Binding Protein Kinase Activity Calcium Ion Binding Protein Binding Kinase Activity Protein Kinase Binding Protein Kinase Activator Activity Ionotropic Glutamate Receptor Binding Alpha-tubulin Binding Protein Serine/threonine Kinase Activator Activity Cadherin Binding Beta-tubulin Binding Actin Filament Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
	Biological Process	TRNA Modification Brain Development TRNA Processing RNA Modification TRNA Methylthiolation Regulation Of Neuron Differentiation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Cycle Positive Regulation Of Translational Fidelity Regulation Of Protein Metabolic Process Positive Regulation Of Mitochondrial Translation Mitochondrial TRNA Modification	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Microtubule Cytoskeleton Organization Neuron Migration Neuron Cell-cell Adhesion G Protein-coupled Acetylcholine Receptor Signaling Pathway Axon Guidance Axonal Fasciculation Brain Development Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cerebellum Development Superior Olivary Nucleus Maturation Hippocampus Development Cerebral Cortex Radially Oriented Cell Migration Layer Formation In Cerebral Cortex Neuron Differentiation Positive Regulation Of Microtubule Polymerization Neuron Projection Development Regulation Of Actin Cytoskeleton Organization Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of MHC Class II Biosynthetic Process Regulation Of Neuron Differentiation Negative Regulation Of DNA-templated Transcription Ephrin Receptor Signaling Pathway Rhythmic Process Regulation Of Dendritic Spine Morphogenesis G1 To G0 Transition Involved In Cell Differentiation Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Pathways		None	CRMPs in Sema3A signaling CRMPs in Sema3A signaling Regulation of TP53 Activity through Phosphorylation Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models NGF-stimulated transcription NGF-stimulated transcription Activated NTRK2 signals through CDK5 NPAS4 regulates expression of target genes
Drugs		None	Indirubin-3'-monoxime 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
GWAS		Diastolic blood pressure ( 30224653 ) Hip circumference adjusted for BMI ( 25673412 34021172 ) Mean corpuscular volume ( 32888494 )	No GWAS studies recorded
Interacting Genes		4 interacting genes: CDK5 CDK5R1 EXOSC3 EXOSC5	35 interacting genes: ACTN1 AMPH APP BCL2L13 BLOC1S6 CAMK2A CAPN1 CAPN2 CDK16 CDK5 CDK5RAP1 CDK5RAP2 CDK5RAP3 CDK9 CHN1 CTNNB1 FEM1B FEM1C HSP90AA1 KRT40 KRTAP10-3 LMTK2 MAPT MTUS2 NEDD4 NES NOTCH2NLA ODF1 PAK1 SEPTIN5 SET SIAH1 STXBP1 TSC22D4 TTBK1
Entrez ID		51654	8851
HPRD ID		12189	04586
Ensembl ID		ENSG00000101391	ENSG00000176749
Uniprot IDs		A0A0S2Z592 A0A0S2Z5J9 Q53H36 Q96SZ6	Q15078 Q8N619
PDB IDs		Not available	1H4L 1UNG 1UNH 1UNL 3O0G 6LDP 7CNG 7VDP 7VDQ 7VDR 7VDS
GO Terms Enriched among Interactors		Protein Kinase 5 Complex Poly(A)-dependent SnoRNA 3'-end Processing U4 SnRNA 3'-end Processing Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity DNA Deamination Nucleolar Exosome (RNase Complex) Exosome (RNase Complex) Nuclear Exosome (RNase Complex) Sno(s)RNA Metabolic Process Layer Formation In Cerebral Cortex SnRNA 3'-end Processing Positive Regulation Of Protein Targeting To Membrane DNA Modification Ionotropic Glutamate Receptor Binding 3'-5'-RNA Exonuclease Activity Regulation Of Protein Targeting To Membrane SnRNA Processing Nuclear RNA Surveillance RNA Surveillance Regulation Of Dendritic Spine Morphogenesis Oligodendrocyte Differentiation Cyclin-dependent Protein Kinase Holoenzyme Complex SnRNA Metabolic Process Cerebellum Development Euchromatin Glial Cell Development Neuron Differentiation Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Hippocampus Development Positive Regulation Of Presynaptic Cytosolic Calcium Concentration Ventral Spinal Cord Interneuron Fate Determination Type B Pancreatic Cell Fate Commitment Neuromuscular Junction RNA 3'-end Processing Microtubule Cytoskeleton Organization Acetylcholine Receptor Activator Activity Glial Cell Differentiation Cell Projection Pancreatic A Cell Fate Commitment Pancreatic PP Cell Fate Commitment Superior Olivary Nucleus Maturation Nuclear-transcribed MRNA Catabolic Process Regulation Of Developmental Process ErbB-2 Class Receptor Binding Negative Regulation Of Synaptic Plasticity Cerebellar Cortex Formation Epithelial Cell Development Spinal Cord Oligodendrocyte Cell Fate Specification	Regulation Of Apoptotic Process Cytoplasm Developmental Process Cytosol Regulation Of Programmed Cell Death Positive Regulation Of Protein Polymerization Receptor Metabolic Process Acetylcholine Receptor Activator Activity Protein Kinase Binding Neurofibrillary Tangle Assembly Neuron Projection Development Protein Serine Kinase Activity Receptor Catabolic Process Developmental Growth Involved In Morphogenesis Apoptotic Process Regulation Of Neuron Apoptotic Process Regulation Of Developmental Process Perinuclear Region Of Cytoplasm Regulation Of Protein Localization Programmed Cell Death Cell Death Protein Serine/threonine Kinase Activity Establishment Of Organelle Localization Calpain Complex Cyclin-dependent Protein Serine/threonine Kinase Activity Amyloid Fibril Formation Cellular Developmental Process Regulation Of Neurotransmitter Secretion Main Axon Vesicle-mediated Transport In Synapse Positive Regulation Of Microtubule Polymerization Dendrite Organelle Localization Cell Differentiation Establishment Of Localization In Cell Regulation Of Cell Differentiation Synaptic Vesicle Transport NMDA Selective Glutamate Receptor Signaling Pathway Positive Regulation Of Protein-containing Complex Assembly Regulation Of Synaptic Plasticity Cell Projection Organization Establishment Of Vesicle Localization Synaptic Vesicle Endocytosis Protein Kinase Activity Neuron Apoptotic Process Neuronal Cell Body Presynaptic Endocytosis Tau Protein Binding Oligodendrocyte Differentiation Developmental Cell Growth